Alternative splicing downstream of EMT enhances phenotypic plasticity and malignant behavior in colon cancer

Alternative splicing downstream of EMT enhances phenotypic plasticity and malignant behavior in colon cancer

Phenotypic plasticity allows carcinoma cells to transiently acquire the quasi-mesenchymal features necessary to detach from the primary mass and proceed along the invasion-metastasis cascade. A broad spectrum of epigenetic mechanisms is likely to cause the epithelial-to-mesenchymal (EMT) and mesench...

Full description

Bibliographic Details
Main Authors: Tong Xu, Mathijs Verhagen, Rosalie Joosten, Wenjie Sun, Andrea Sacchetti, Leonel Munoz Sagredo, Véronique Orian-Rousseau, Riccardo Fodde
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-11-01
Series:eLife
Subjects:
EMT
RNA-binding protein
ESRP1
CD44
NUMB
CMS4
Online Access:https://elifesciences.org/articles/82006

Similar Items

Similar Items