A Role for K-ras in Conferring Resistance to the MEK Inhibitor, CI-1040

A Role for K-ras in Conferring Resistance to the MEK Inhibitor, CI-1040

PD184352/CI-1040 is a potent and selective MEK1/2 inhibitor that represents the first MEK-targeted agent to enter clinical trials. Here, we report the development and molecular characterization of CI-1040 resistance in the murine colon 26 (C26) carcinoma cell line. The growth rate of the resistant l...

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Bibliographic Details
Main Authors: Yuli Wangab, Keri Van Becelaere, Ping Jiang, Sally Przybranowski, Charles Omer, Judith Sebolt-Leopold
Format: Article
Language:English
Published: Elsevier 2005-04-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
MEK
ERK
Ras
CI-1040
C26
Online Access:http://www.sciencedirect.com/science/article/pii/S147655860580065X

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