Silicon Photonic Biosensors Using Label-Free Detection
Thanks to advanced semiconductor microfabrication technology, chip-scale integration and miniaturization of lab-on-a-chip components, silicon-based optical biosensors have made significant progress for the purpose of point-of-care diagnosis. In this review, we provide an overview of the state-of-the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-10-01
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| Series: | Sensors |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1424-8220/18/10/3519 |
| _version_ | 1798040288512442368 |
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| author | Enxiao Luan Hossam Shoman Daniel M. Ratner Karen C. Cheung Lukas Chrostowski |
| author_facet | Enxiao Luan Hossam Shoman Daniel M. Ratner Karen C. Cheung Lukas Chrostowski |
| author_sort | Enxiao Luan |
| collection | DOAJ |
| description | Thanks to advanced semiconductor microfabrication technology, chip-scale integration and miniaturization of lab-on-a-chip components, silicon-based optical biosensors have made significant progress for the purpose of point-of-care diagnosis. In this review, we provide an overview of the state-of-the-art in evanescent field biosensing technologies including interferometer, microcavity, photonic crystal, and Bragg grating waveguide-based sensors. Their sensing mechanisms and sensor performances, as well as real biomarkers for label-free detection, are exhibited and compared. We also review the development of chip-level integration for lab-on-a-chip photonic sensing platforms, which consist of the optical sensing device, flow delivery system, optical input and readout equipment. At last, some advanced system-level complementary metal-oxide semiconductor (CMOS) chip packaging examples are presented, indicating the commercialization potential for the low cost, high yield, portable biosensing platform leveraging CMOS processes. |
| first_indexed | 2024-04-11T22:05:33Z |
| format | Article |
| id | doaj.art-b2bc033cbfba423ba107225a2a77c650 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T22:05:33Z |
| publishDate | 2018-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-b2bc033cbfba423ba107225a2a77c6502022-12-22T04:00:44ZengMDPI AGSensors1424-82202018-10-011810351910.3390/s18103519s18103519Silicon Photonic Biosensors Using Label-Free DetectionEnxiao Luan0Hossam Shoman1Daniel M. Ratner2Karen C. Cheung3Lukas Chrostowski4Department of Electrical and Computer Engineering, University of British Columbia, 2329 West Mall, Vancouver, BC V6T 1Z4, CanadaDepartment of Electrical and Computer Engineering, University of British Columbia, 2329 West Mall, Vancouver, BC V6T 1Z4, CanadaDepartment of Bioengineering, University of Washington, 3720 15th Ave. NE, Seattle, WA 98195-5061, USADepartment of Electrical and Computer Engineering, University of British Columbia, 2329 West Mall, Vancouver, BC V6T 1Z4, CanadaDepartment of Electrical and Computer Engineering, University of British Columbia, 2329 West Mall, Vancouver, BC V6T 1Z4, CanadaThanks to advanced semiconductor microfabrication technology, chip-scale integration and miniaturization of lab-on-a-chip components, silicon-based optical biosensors have made significant progress for the purpose of point-of-care diagnosis. In this review, we provide an overview of the state-of-the-art in evanescent field biosensing technologies including interferometer, microcavity, photonic crystal, and Bragg grating waveguide-based sensors. Their sensing mechanisms and sensor performances, as well as real biomarkers for label-free detection, are exhibited and compared. We also review the development of chip-level integration for lab-on-a-chip photonic sensing platforms, which consist of the optical sensing device, flow delivery system, optical input and readout equipment. At last, some advanced system-level complementary metal-oxide semiconductor (CMOS) chip packaging examples are presented, indicating the commercialization potential for the low cost, high yield, portable biosensing platform leveraging CMOS processes.http://www.mdpi.com/1424-8220/18/10/3519silicon photonicsevanescent optical field sensorlabel-free SOI biosensorMach–Zehnder interferometerring resonatorphotonic crystalBragg gratingsub-wavelength gratinglab-on-a-chipmicrofluidics |
| spellingShingle | Enxiao Luan Hossam Shoman Daniel M. Ratner Karen C. Cheung Lukas Chrostowski Silicon Photonic Biosensors Using Label-Free Detection Sensors silicon photonics evanescent optical field sensor label-free SOI biosensor Mach–Zehnder interferometer ring resonator photonic crystal Bragg grating sub-wavelength grating lab-on-a-chip microfluidics |
| title | Silicon Photonic Biosensors Using Label-Free Detection |
| title_full | Silicon Photonic Biosensors Using Label-Free Detection |
| title_fullStr | Silicon Photonic Biosensors Using Label-Free Detection |
| title_full_unstemmed | Silicon Photonic Biosensors Using Label-Free Detection |
| title_short | Silicon Photonic Biosensors Using Label-Free Detection |
| title_sort | silicon photonic biosensors using label free detection |
| topic | silicon photonics evanescent optical field sensor label-free SOI biosensor Mach–Zehnder interferometer ring resonator photonic crystal Bragg grating sub-wavelength grating lab-on-a-chip microfluidics |
| url | http://www.mdpi.com/1424-8220/18/10/3519 |
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