Impact of coronavirus disease 2019 (COVID-19) on antimicrobial resistance among major pathogens causing healthcare-associated infection
Background: Coronavirus disease 2019 (COVID-19) has caused great impact on healthcare systems, including antibiotic usage and multi-drug resistant (MDR) bacterial infections at hospitals. We aim to investigate the trends of antimicrobial resistance among the major pathogens causing healthcare-associ...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664623002541 |
| _version_ | 1797348651350097920 |
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| author | Hao-Chun Chang Che-Hao Chang Kuei-Lien Tien Chih-Hsun Tai Li-Min Lin Tai-Fen Lee Shih-Chi Ku Chi-Tai Fang Yee-Chun Chen Wang-Huei Sheng |
| author_facet | Hao-Chun Chang Che-Hao Chang Kuei-Lien Tien Chih-Hsun Tai Li-Min Lin Tai-Fen Lee Shih-Chi Ku Chi-Tai Fang Yee-Chun Chen Wang-Huei Sheng |
| author_sort | Hao-Chun Chang |
| collection | DOAJ |
| description | Background: Coronavirus disease 2019 (COVID-19) has caused great impact on healthcare systems, including antibiotic usage and multi-drug resistant (MDR) bacterial infections at hospitals. We aim to investigate the trends of antimicrobial resistance among the major pathogens causing healthcare-associated infection (HAI) at intensive care units (ICU). Material and methods: The demographic characteristics of hospitalization, usage of antimicrobial agents, counted by half-an-year DID (defined daily dose per 1000 patient-days), and HAI density of five major MDR bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), carbapenem-resistant Acinetobacter baumannii (CRAB), carbapenem-resistant Klebsiella pneumoniae (CRKP), and carbapenem-resistant Pseudomonas aeruginosa (CRPA), of ICU patients at a medical center in Taiwan during January 2017 to December 2021 were collected and analyzed. Results: The total antibiotic usage, counted by DID, had a significant increasing trend, before COVID-19 occurrence in 2017–2019, but no further increase during the pandemic period in 2020–2021. However, comparing the two time periods, antibiotics consumption was significantly increased during pandemic period. There was no significant change of HAI density in MRSA, VRE, CRAB, CRKP, and CRPA, comparing the pandemic to the pre-pandemic period. Although, CRKP and CRPA infection rates were increasing during the pre-pandemic period, there was no further increase of CRKP and CRPA HAI rates during the pandemic period. Conclusion: During COVID-19 pandemic, there was no significant increase in HAI density of five major MDR bacteria at ICU in Taiwan, despite increased antibiotic usage. Strict infection prevention measures for COVID-19 precautions and sustained antimicrobial stewardship probably bring these effects. |
| first_indexed | 2024-03-08T12:08:59Z |
| format | Article |
| id | doaj.art-b2bc8755fc614e98a5de836ed7d46dce |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-03-08T12:08:59Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-b2bc8755fc614e98a5de836ed7d46dce2024-01-23T04:15:05ZengElsevierJournal of the Formosan Medical Association0929-66462024-01-011231123132Impact of coronavirus disease 2019 (COVID-19) on antimicrobial resistance among major pathogens causing healthcare-associated infectionHao-Chun Chang0Che-Hao Chang1Kuei-Lien Tien2Chih-Hsun Tai3Li-Min Lin4Tai-Fen Lee5Shih-Chi Ku6Chi-Tai Fang7Yee-Chun Chen8Wang-Huei Sheng9Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Taiwan University Hsin-Chu Branch, Biomedical Park Hospital, Hsin-Chu County, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei City, TaiwanInfection Control Center, National Taiwan University Hospital, Taipei City, TaiwanDepartment of Pharmacy, National Taiwan University Hospital, Taipei City, TaiwanDepartment of Nursing, National Taiwan University Hospital, Taipei City, TaiwanDepartment of Laboratory Medicine, National Taiwan University Hospital, Taipei City, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Taiwan University Hospital, Taipei City, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei City, Taiwan; Division of Infectious Disease, Department of Internal Medicine, National Taiwan University Hospital, Taipei City, TaiwanDivision of Infectious Disease, Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan; School of Medicine, National Taiwan University College of Medicine, Taipei City, TaiwanDivision of Infectious Disease, Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan; School of Medicine, National Taiwan University College of Medicine, Taipei City, Taiwan; Corresponding author. Division of Infectious Disease, Department of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan.Background: Coronavirus disease 2019 (COVID-19) has caused great impact on healthcare systems, including antibiotic usage and multi-drug resistant (MDR) bacterial infections at hospitals. We aim to investigate the trends of antimicrobial resistance among the major pathogens causing healthcare-associated infection (HAI) at intensive care units (ICU). Material and methods: The demographic characteristics of hospitalization, usage of antimicrobial agents, counted by half-an-year DID (defined daily dose per 1000 patient-days), and HAI density of five major MDR bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), carbapenem-resistant Acinetobacter baumannii (CRAB), carbapenem-resistant Klebsiella pneumoniae (CRKP), and carbapenem-resistant Pseudomonas aeruginosa (CRPA), of ICU patients at a medical center in Taiwan during January 2017 to December 2021 were collected and analyzed. Results: The total antibiotic usage, counted by DID, had a significant increasing trend, before COVID-19 occurrence in 2017–2019, but no further increase during the pandemic period in 2020–2021. However, comparing the two time periods, antibiotics consumption was significantly increased during pandemic period. There was no significant change of HAI density in MRSA, VRE, CRAB, CRKP, and CRPA, comparing the pandemic to the pre-pandemic period. Although, CRKP and CRPA infection rates were increasing during the pre-pandemic period, there was no further increase of CRKP and CRPA HAI rates during the pandemic period. Conclusion: During COVID-19 pandemic, there was no significant increase in HAI density of five major MDR bacteria at ICU in Taiwan, despite increased antibiotic usage. Strict infection prevention measures for COVID-19 precautions and sustained antimicrobial stewardship probably bring these effects.http://www.sciencedirect.com/science/article/pii/S0929664623002541COVID-19 pandemicAntibiotic usageMulti-drug resistant bacteriaHealthcare-associated infection |
| spellingShingle | Hao-Chun Chang Che-Hao Chang Kuei-Lien Tien Chih-Hsun Tai Li-Min Lin Tai-Fen Lee Shih-Chi Ku Chi-Tai Fang Yee-Chun Chen Wang-Huei Sheng Impact of coronavirus disease 2019 (COVID-19) on antimicrobial resistance among major pathogens causing healthcare-associated infection Journal of the Formosan Medical Association COVID-19 pandemic Antibiotic usage Multi-drug resistant bacteria Healthcare-associated infection |
| title | Impact of coronavirus disease 2019 (COVID-19) on antimicrobial resistance among major pathogens causing healthcare-associated infection |
| title_full | Impact of coronavirus disease 2019 (COVID-19) on antimicrobial resistance among major pathogens causing healthcare-associated infection |
| title_fullStr | Impact of coronavirus disease 2019 (COVID-19) on antimicrobial resistance among major pathogens causing healthcare-associated infection |
| title_full_unstemmed | Impact of coronavirus disease 2019 (COVID-19) on antimicrobial resistance among major pathogens causing healthcare-associated infection |
| title_short | Impact of coronavirus disease 2019 (COVID-19) on antimicrobial resistance among major pathogens causing healthcare-associated infection |
| title_sort | impact of coronavirus disease 2019 covid 19 on antimicrobial resistance among major pathogens causing healthcare associated infection |
| topic | COVID-19 pandemic Antibiotic usage Multi-drug resistant bacteria Healthcare-associated infection |
| url | http://www.sciencedirect.com/science/article/pii/S0929664623002541 |
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