Solitary Fibrous Tumors of Chest: Another Look with the Oncologic Perspective
Solitary fibrous tumors are mesenchymal lesions that arise at a variety of sites, most commonly the pleura. Thoracic forms are generally asymptomatic at the time of diagnosis, and the radiographic features are a well-circumscribed, peripheral mass that abuts the pleural surface, frequently attached...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2017-06-01
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| Series: | Balkan Medical Journal |
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| Online Access: | http://balkanmedicaljournal.org/text.php?lang=en&id=1688 |
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| author | Mert Saynak Nirmal K. Veeramachaneni Jessica L. Hubbs Dilruba Okumuş Lawrence B. Marks |
| author_facet | Mert Saynak Nirmal K. Veeramachaneni Jessica L. Hubbs Dilruba Okumuş Lawrence B. Marks |
| author_sort | Mert Saynak |
| collection | DOAJ |
| description | Solitary fibrous tumors are mesenchymal lesions that arise at a variety of sites, most commonly the pleura. Thoracic forms are generally asymptomatic at the time of diagnosis, and the radiographic features are a well-circumscribed, peripheral mass that abuts the pleural surface, frequently attached by a pedicle.
Solitary fibrous tumors are mesenchymal lesions that arise at a variety of sites, most commonly the pleura. Most patients are asymptomatic at diagnosis, with lesions being detected incidentally. Nevertheless, some patients present due to symptoms from local tumor compression (eg. of the airways and pulmonary parenchyma). Furthermore, radiological methods are not always conclusive in making a diagnosis, and thus, pathological analysis is often required. In the past three decades, immunohistochemical techniques have provided a gold standard in solitary fibrous tumor diagnosis. The signature marker of solitary fibrous tumor is the presence of the NAB2-STAT6 fusion that can be reliably detected with a STAT6 antibody. While solitary fibrous tumors are most often benign, they can be malignant in 10-20% of the cases. Unfortunately, histological parameters are not always predictive of benign vs malignant solitary fibrous tumors. As solitary fibrous tumors are generally regarded as relatively chemoresistant tumors; treatment is often limited to localized treatment modalities. The optimal treatment of solitary fibrous tumors appears to be complete surgical resection for both primary and local recurrent disease. However, in cases of suboptimal resection, large disease burden, or advanced recurrence, a multidisciplinary approach may be preferable. Specifically, radiotherapy for inoperable local disease can provide palliation/shrinkage. Given their sometimes -unpredictable and often- protracted clinical course, long-term follow-up post-resection is recommended |
| first_indexed | 2024-04-10T12:49:46Z |
| format | Article |
| id | doaj.art-b2be3cb50b00415696177ee64a4ac563 |
| institution | Directory Open Access Journal |
| issn | 2146-3123 2146-3131 |
| language | English |
| last_indexed | 2024-04-10T12:49:46Z |
| publishDate | 2017-06-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Balkan Medical Journal |
| spelling | doaj.art-b2be3cb50b00415696177ee64a4ac5632023-02-15T16:13:53ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312017-06-0134318819910.4274/balkanmedj.2017.0350Solitary Fibrous Tumors of Chest: Another Look with the Oncologic PerspectiveMert Saynak0Nirmal K. Veeramachaneni1Jessica L. Hubbs2Dilruba Okumuş3Lawrence B. Marks4Department of Radiation Oncology, Trakya University School of Medicine, Edirne, TurkeyDepartment of Cardiovascular Surgery, University of Kansas Medical Center, Kansas City, USADepartment of Obstetrics and Gynecology, University of North Carolina, North Carolina, USADepartment of Radiation Oncology, Trakya University School of Medicine, Edirne, TurkeyDepartment of Radiation Oncology, University of North Carolina, North Carolina, USASolitary fibrous tumors are mesenchymal lesions that arise at a variety of sites, most commonly the pleura. Thoracic forms are generally asymptomatic at the time of diagnosis, and the radiographic features are a well-circumscribed, peripheral mass that abuts the pleural surface, frequently attached by a pedicle. Solitary fibrous tumors are mesenchymal lesions that arise at a variety of sites, most commonly the pleura. Most patients are asymptomatic at diagnosis, with lesions being detected incidentally. Nevertheless, some patients present due to symptoms from local tumor compression (eg. of the airways and pulmonary parenchyma). Furthermore, radiological methods are not always conclusive in making a diagnosis, and thus, pathological analysis is often required. In the past three decades, immunohistochemical techniques have provided a gold standard in solitary fibrous tumor diagnosis. The signature marker of solitary fibrous tumor is the presence of the NAB2-STAT6 fusion that can be reliably detected with a STAT6 antibody. While solitary fibrous tumors are most often benign, they can be malignant in 10-20% of the cases. Unfortunately, histological parameters are not always predictive of benign vs malignant solitary fibrous tumors. As solitary fibrous tumors are generally regarded as relatively chemoresistant tumors; treatment is often limited to localized treatment modalities. The optimal treatment of solitary fibrous tumors appears to be complete surgical resection for both primary and local recurrent disease. However, in cases of suboptimal resection, large disease burden, or advanced recurrence, a multidisciplinary approach may be preferable. Specifically, radiotherapy for inoperable local disease can provide palliation/shrinkage. Given their sometimes -unpredictable and often- protracted clinical course, long-term follow-up post-resection is recommendedhttp://balkanmedicaljournal.org/text.php?lang=en&id=1688Solitary fibrous tumorhemangiopericytomasarcomaradiotherapychemotherapymolecular targeted therapies |
| spellingShingle | Mert Saynak Nirmal K. Veeramachaneni Jessica L. Hubbs Dilruba Okumuş Lawrence B. Marks Solitary Fibrous Tumors of Chest: Another Look with the Oncologic Perspective Balkan Medical Journal Solitary fibrous tumor hemangiopericytoma sarcoma radiotherapy chemotherapy molecular targeted therapies |
| title | Solitary Fibrous Tumors of Chest: Another Look with the Oncologic Perspective |
| title_full | Solitary Fibrous Tumors of Chest: Another Look with the Oncologic Perspective |
| title_fullStr | Solitary Fibrous Tumors of Chest: Another Look with the Oncologic Perspective |
| title_full_unstemmed | Solitary Fibrous Tumors of Chest: Another Look with the Oncologic Perspective |
| title_short | Solitary Fibrous Tumors of Chest: Another Look with the Oncologic Perspective |
| title_sort | solitary fibrous tumors of chest another look with the oncologic perspective |
| topic | Solitary fibrous tumor hemangiopericytoma sarcoma radiotherapy chemotherapy molecular targeted therapies |
| url | http://balkanmedicaljournal.org/text.php?lang=en&id=1688 |
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