Optimization of the reaction conditions for the synthesis of 2,3,5-trimethylpyridine from 3-amino-2-methylpropenal and methylethylketone
The influence of temperature, reaction time, and type of the catalyst on the yield of the 2,3,5-trimethylpyridine (collidine) from 3-amino-2-methylpropenal and methylethylketone was investigated. 3-Amino-2-methylpropenal was synthesized from 3-ethoxy-2-methylacrolein previously synthesized from meth...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2022-01-01
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| Series: | Journal of the Serbian Chemical Society |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2022/0352-51392200042U.pdf |
| _version_ | 1828171823030730752 |
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| author | Urošević Jovica Mitić Miroslav Arsić Biljana Stojanović Gordana |
| author_facet | Urošević Jovica Mitić Miroslav Arsić Biljana Stojanović Gordana |
| author_sort | Urošević Jovica |
| collection | DOAJ |
| description | The influence of temperature, reaction time, and type of the catalyst on the yield of the 2,3,5-trimethylpyridine (collidine) from 3-amino-2-methylpropenal and methylethylketone was investigated. 3-Amino-2-methylpropenal was synthesized from 3-ethoxy-2-methylacrolein previously synthesized from methylmalondialdehyde tetraethyl acetal, obtained from triethyl orthoformate and propenyl ether. The optimal conditions for the investigated synthesis were temperature of 150 °C, reaction time 24 h, and the CH3COOH/pTsOH catalyst. This synthesis is the first successful attempt to synthesize 2,3,5-trimethylpyridine in an acid medium. |
| first_indexed | 2024-04-12T03:31:24Z |
| format | Article |
| id | doaj.art-b2bef4e08f374877b135fdc5f432e39d |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-04-12T03:31:24Z |
| publishDate | 2022-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-b2bef4e08f374877b135fdc5f432e39d2022-12-22T03:49:32ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212022-01-0187101117112310.2298/JSC210918042U0352-51392200042UOptimization of the reaction conditions for the synthesis of 2,3,5-trimethylpyridine from 3-amino-2-methylpropenal and methylethylketoneUrošević Jovica0Mitić Miroslav1https://orcid.org/0000-0003-3658-9921Arsić Biljana2https://orcid.org/0000-0002-1248-5864Stojanović Gordana3https://orcid.org/0000-0002-3128-6510Chemical-technological school “Božidar Đorđevic Kukar”, Leskovac, SerbiaChemical-technological school “Božidar Đorđevic Kukar”, Leskovac, SerbiaUniversity of Niš, Faculty of Sciences and Mathematics, Department of Chemistry, Niš, SerbiaUniversity of Niš, Faculty of Sciences and Mathematics, Department of Chemistry, Niš, SerbiaThe influence of temperature, reaction time, and type of the catalyst on the yield of the 2,3,5-trimethylpyridine (collidine) from 3-amino-2-methylpropenal and methylethylketone was investigated. 3-Amino-2-methylpropenal was synthesized from 3-ethoxy-2-methylacrolein previously synthesized from methylmalondialdehyde tetraethyl acetal, obtained from triethyl orthoformate and propenyl ether. The optimal conditions for the investigated synthesis were temperature of 150 °C, reaction time 24 h, and the CH3COOH/pTsOH catalyst. This synthesis is the first successful attempt to synthesize 2,3,5-trimethylpyridine in an acid medium.http://www.doiserbia.nb.rs/img/doi/0352-5139/2022/0352-51392200042U.pdfcyclic condensationgc-msside reactions |
| spellingShingle | Urošević Jovica Mitić Miroslav Arsić Biljana Stojanović Gordana Optimization of the reaction conditions for the synthesis of 2,3,5-trimethylpyridine from 3-amino-2-methylpropenal and methylethylketone Journal of the Serbian Chemical Society cyclic condensation gc-ms side reactions |
| title | Optimization of the reaction conditions for the synthesis of 2,3,5-trimethylpyridine from 3-amino-2-methylpropenal and methylethylketone |
| title_full | Optimization of the reaction conditions for the synthesis of 2,3,5-trimethylpyridine from 3-amino-2-methylpropenal and methylethylketone |
| title_fullStr | Optimization of the reaction conditions for the synthesis of 2,3,5-trimethylpyridine from 3-amino-2-methylpropenal and methylethylketone |
| title_full_unstemmed | Optimization of the reaction conditions for the synthesis of 2,3,5-trimethylpyridine from 3-amino-2-methylpropenal and methylethylketone |
| title_short | Optimization of the reaction conditions for the synthesis of 2,3,5-trimethylpyridine from 3-amino-2-methylpropenal and methylethylketone |
| title_sort | optimization of the reaction conditions for the synthesis of 2 3 5 trimethylpyridine from 3 amino 2 methylpropenal and methylethylketone |
| topic | cyclic condensation gc-ms side reactions |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2022/0352-51392200042U.pdf |
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