Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota
Abstract Colorectal cancer (CRC) is the third most common cancer worldwide. One of the main causes of colorectal cancer is inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease (CD). Intestinal epithelial cells (IECs), intestinal mesenchymal cells (IMCs), immun...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | Cell & Bioscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13578-023-01139-8 |
| _version_ | 1797556181238022144 |
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| author | Junshu Li Yanhong Ji Na Chen Lei Dai Hongxin Deng |
| author_facet | Junshu Li Yanhong Ji Na Chen Lei Dai Hongxin Deng |
| author_sort | Junshu Li |
| collection | DOAJ |
| description | Abstract Colorectal cancer (CRC) is the third most common cancer worldwide. One of the main causes of colorectal cancer is inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease (CD). Intestinal epithelial cells (IECs), intestinal mesenchymal cells (IMCs), immune cells, and gut microbiota construct the main body of the colon and maintain colon homeostasis. In the development of colitis and colitis-associated carcinogenesis, the damage, disorder or excessive recruitment of different cells such as IECs, IMCs, immune cells and intestinal microbiota play different roles during these processes. This review aims to discuss the various roles of different cells and the crosstalk of these cells in transforming intestinal inflammation to cancer, which provides new therapeutic methods for chemotherapy, targeted therapy, immunotherapy and microbial therapy. |
| first_indexed | 2024-03-10T16:58:16Z |
| format | Article |
| id | doaj.art-b2bf52be51af4f85b56c226efed7aa32 |
| institution | Directory Open Access Journal |
| issn | 2045-3701 |
| language | English |
| last_indexed | 2024-03-10T16:58:16Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj.art-b2bf52be51af4f85b56c226efed7aa322023-11-20T11:03:50ZengBMCCell & Bioscience2045-37012023-10-0113111910.1186/s13578-023-01139-8Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiotaJunshu Li0Yanhong Ji1Na Chen2Lei Dai3Hongxin Deng4Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityDepartment of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityAbstract Colorectal cancer (CRC) is the third most common cancer worldwide. One of the main causes of colorectal cancer is inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease (CD). Intestinal epithelial cells (IECs), intestinal mesenchymal cells (IMCs), immune cells, and gut microbiota construct the main body of the colon and maintain colon homeostasis. In the development of colitis and colitis-associated carcinogenesis, the damage, disorder or excessive recruitment of different cells such as IECs, IMCs, immune cells and intestinal microbiota play different roles during these processes. This review aims to discuss the various roles of different cells and the crosstalk of these cells in transforming intestinal inflammation to cancer, which provides new therapeutic methods for chemotherapy, targeted therapy, immunotherapy and microbial therapy.https://doi.org/10.1186/s13578-023-01139-8Colitis-associated carcinogenesisIBD therapyIntestinal epithelial cellsIntestinal mesenchymal cellsImmune cellsGut microbiota |
| spellingShingle | Junshu Li Yanhong Ji Na Chen Lei Dai Hongxin Deng Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota Cell & Bioscience Colitis-associated carcinogenesis IBD therapy Intestinal epithelial cells Intestinal mesenchymal cells Immune cells Gut microbiota |
| title | Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota |
| title_full | Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota |
| title_fullStr | Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota |
| title_full_unstemmed | Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota |
| title_short | Colitis-associated carcinogenesis: crosstalk between tumors, immune cells and gut microbiota |
| title_sort | colitis associated carcinogenesis crosstalk between tumors immune cells and gut microbiota |
| topic | Colitis-associated carcinogenesis IBD therapy Intestinal epithelial cells Intestinal mesenchymal cells Immune cells Gut microbiota |
| url | https://doi.org/10.1186/s13578-023-01139-8 |
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