Computational Modeling of the Neurofibromin-Stimulated Guanosine Triphosphate Hydrolysis by the KRas Protein
We report the results of computational studies of the guanosine triphosphate (GTP) hydrolysis in the active site of the KRas-NF1 protein complex, where KRas stands for the K-isoform of the Ras (ras sarcoma) protein and NF1 (neurofbromin-1) is the activating protein. The model system was constructed...
Main Authors: | Igor Polyakov, Alexander Nemukhin |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-05-01
|
Series: | Biophysica |
Subjects: | |
Online Access: | https://www.mdpi.com/2673-4125/3/2/25 |
Similar Items
-
Mechanism of Guanosine Triphosphate Hydrolysis by the Visual Proteins Arl3-RP2: Free Energy Reaction Profiles Computed with Ab Initio Type QM/MM Potentials
by: Maria G. Khrenova, et al.
Published: (2021-06-01) -
The identification of protein domains that mediate functional interactions between Rab-GTPases and RabGAPs using 3D protein modeling
by: Davie JJ, et al.
Published: (2017-04-01) -
A Small Guanosine Triphosphate Binding Protein PagRabE1b Promotes Xylem Development in Poplar
by: Ying-Li Liu, et al.
Published: (2021-06-01) -
Two Sides of Quantum-Based Modeling of Enzyme-Catalyzed Reactions: Mechanistic and Electronic Structure Aspects of the Hydrolysis by Glutamate Carboxypeptidase
by: Alexandra V. Krivitskaya, et al.
Published: (2021-10-01) -
The Therapeutic Landscape for <i>KRAS</i>-Mutated Colorectal Cancers
by: Simon Manuel Tria, et al.
Published: (2023-04-01)