In Vitro and In Vivo Chaperone Effect of (R)-2-amino-6-(1R, 2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropterin-4(3H)-one on the C1473G Mutant Tryptophan Hydroxylase 2

In Vitro and In Vivo Chaperone Effect of (R)-2-amino-6-(1R, 2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropterin-4(3H)-one on the C1473G Mutant Tryptophan Hydroxylase 2

Tryptophan hydroxylase 2 (TPH2) is the key and rate-limiting enzyme of serotonin (5-HT) synthesis in the mammalian brain. The 1473G mutation in the Tph2 gene decreases TPH2 activity in the mouse brain by twofold. (R)-2-amino-6-(1R, 2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropterin-4(3H)-one (BH<s...

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Bibliographic Details
Main Authors: Alla B. Arefieva, Polina D. Komleva, Vladimir S. Naumenko, Nikita V. Khotskin, Alexander V. Kulikov
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Biomolecules
Subjects:
serotonin
tryptophan hydroxylase 2
tetrahydrobiopterin
thermal stability
behavior
brain
Online Access:https://www.mdpi.com/2218-273X/13/10/1458

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