Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from <it>Viola websteri </it>in mice
<p>Abstract</p> <p>Background</p> <p>Petroleum ether extracts of <it>Viola websteri </it>Hemsl (Violaceae) were reported to have anti-plasmodial activity against <it>Plasmodium falciparum in vitro</it>, with this activity being largely attributab...
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| Format: | Article |
| Language: | English |
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BMC
2009-07-01
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| Series: | Malaria Journal |
| Online Access: | http://www.malariajournal.com/content/8/1/151 |
| _version_ | 1819057768889319424 |
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| author | Park Won-Hwan Kang Eun-Young Seo Su-Hyun Chung Ill-Min Moon Hyung-In |
| author_facet | Park Won-Hwan Kang Eun-Young Seo Su-Hyun Chung Ill-Min Moon Hyung-In |
| author_sort | Park Won-Hwan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Petroleum ether extracts of <it>Viola websteri </it>Hemsl (Violaceae) were reported to have anti-plasmodial activity against <it>Plasmodium falciparum in vitro</it>, with this activity being largely attributable to 6-(8'Z-pentadecenyl)-salicylic acid (6-SA).</p> <p>Methods</p> <p>The schizontocidal activity of 6-SA on early <it>Plasmodium berghei </it>infections was evaluated in a four-day test. The possible 'repository' activity of 6-SA was assessed using the method described by Peters. The median lethal dose (LD<sub>50</sub>) of 6-SA, when given intraperitoneally, was also determined using uninfected ICR mice and the method of Lorke.</p> <p>Results</p> <p>In the present study, 6-SA was found to have anti-malarial activity <it>in vivo</it>, when tested against <it>P. berghei </it>in mice. 6-SA at 5, 10 and 25 mg/kg·day exhibited a significant blood schizontocidal activity in four-day early infections, repository evaluations and established infections with a significant mean survival time comparable to that of the standard drug, chloroquine (5 mg/kg·day).</p> <p>Conclusion</p> <p>6-SA possesses a moderate anti-malarial activity that could be exploited for malaria therapy.</p> |
| first_indexed | 2024-12-21T13:44:34Z |
| format | Article |
| id | doaj.art-b2c5d49291254ad4a493f4a6f1341e93 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-12-21T13:44:34Z |
| publishDate | 2009-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-b2c5d49291254ad4a493f4a6f1341e932022-12-21T19:01:56ZengBMCMalaria Journal1475-28752009-07-018115110.1186/1475-2875-8-151Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from <it>Viola websteri </it>in micePark Won-HwanKang Eun-YoungSeo Su-HyunChung Ill-MinMoon Hyung-In<p>Abstract</p> <p>Background</p> <p>Petroleum ether extracts of <it>Viola websteri </it>Hemsl (Violaceae) were reported to have anti-plasmodial activity against <it>Plasmodium falciparum in vitro</it>, with this activity being largely attributable to 6-(8'Z-pentadecenyl)-salicylic acid (6-SA).</p> <p>Methods</p> <p>The schizontocidal activity of 6-SA on early <it>Plasmodium berghei </it>infections was evaluated in a four-day test. The possible 'repository' activity of 6-SA was assessed using the method described by Peters. The median lethal dose (LD<sub>50</sub>) of 6-SA, when given intraperitoneally, was also determined using uninfected ICR mice and the method of Lorke.</p> <p>Results</p> <p>In the present study, 6-SA was found to have anti-malarial activity <it>in vivo</it>, when tested against <it>P. berghei </it>in mice. 6-SA at 5, 10 and 25 mg/kg·day exhibited a significant blood schizontocidal activity in four-day early infections, repository evaluations and established infections with a significant mean survival time comparable to that of the standard drug, chloroquine (5 mg/kg·day).</p> <p>Conclusion</p> <p>6-SA possesses a moderate anti-malarial activity that could be exploited for malaria therapy.</p>http://www.malariajournal.com/content/8/1/151 |
| spellingShingle | Park Won-Hwan Kang Eun-Young Seo Su-Hyun Chung Ill-Min Moon Hyung-In Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from <it>Viola websteri </it>in mice Malaria Journal |
| title | Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from <it>Viola websteri </it>in mice |
| title_full | Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from <it>Viola websteri </it>in mice |
| title_fullStr | Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from <it>Viola websteri </it>in mice |
| title_full_unstemmed | Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from <it>Viola websteri </it>in mice |
| title_short | Anti-malarial activity of 6-(8'Z-pentadecenyl)-salicylic acid from <it>Viola websteri </it>in mice |
| title_sort | anti malarial activity of 6 8 z pentadecenyl salicylic acid from it viola websteri it in mice |
| url | http://www.malariajournal.com/content/8/1/151 |
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