Full-Right Full-Left Split Liver Transplantation for Two Adult Recipients: A Single-Center Experience in China
Background: The most effective treatment for end-stage liver diseases is liver transplantation, which is impeded by the shortage of donor livers. Split liver transplantation (SLT) is important for addressing the donor liver shortage. However, full-right full-left SLT for two adult recipients is glob...
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| Format: | Article |
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MDPI AG
2023-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/11/3782 |
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| author | Limin Ding Xizhi Yu Rui Zhang Junjie Qian Wu Zhang Qinchuan Wu Lin Zhou Zhe Yang Shusen Zheng |
| author_facet | Limin Ding Xizhi Yu Rui Zhang Junjie Qian Wu Zhang Qinchuan Wu Lin Zhou Zhe Yang Shusen Zheng |
| author_sort | Limin Ding |
| collection | DOAJ |
| description | Background: The most effective treatment for end-stage liver diseases is liver transplantation, which is impeded by the shortage of donor livers. Split liver transplantation (SLT) is important for addressing the donor liver shortage. However, full-right full-left SLT for two adult recipients is globally rarely conducted. This study aimed to investigate the clinical outcomes of this technique. Methods: We retrospectively analyzed the clinical data of 22 recipients who underwent full-right full-left SLT at Shulan (Hangzhou) Hospital between January, 2021 and September, 2022. The graft-to-recipient weight ratio (GRWR), cold ischemia time, operation time, length of the anhepatic phase, intraoperative blood loss, and red blood cell transfusion amount were all analyzed. The differences in liver function recovery after transplantation were compared between the left and right hemiliver groups. The postoperative complications and prognosis of the recipients were also analyzed. Results: The livers of 11 donors were transplanted into 22 adult recipients. The GRWR ranged from 1.16–1.65%, the cold ischemia time was 282.86 ± 134.87 min, the operation time was 371.32 ± 75.36 min, the anhepatic phase lasted 60.73 ± 19.00 min, the intraoperative blood loss was 759.09 ± 316.84 mL, and the red blood cell transfusion amount was 695.45 ± 393.67 mL. No significant difference in the levels of liver function markers, total bilirubin, aspartate aminotransferase, or alanine aminotransferase between left and right hemiliver groups at 1, 3, 5, 7, 14, and 28 d postoperatively was observed (both <i>p</i> > 0.05). One recipient developed bile leakage 10 d after transplantation, which improved with endoscopic retrograde cholangiopancreatography-guided nasobiliary drainage and stent placement. Another developed portal vein thrombosis 12 d after transplantation and underwent portal vein thrombolytic therapy and stenting to restore portal vein blood flow. A color Doppler ultrasound performed 2 d after transplantation revealed hepatic artery thrombosis in one patient, and thrombolytic therapy was administered to restore hepatic artery blood flow. The liver function of other patients recovered quickly after transplantation. Conclusions: Full-right full-left SLT for two adult patients is an efficient way to increase the donor pool. It is safe and feasible with careful donor and recipient selection. Transplant hospitals with highly experienced surgeons in SLT are recommended to promote using full-right full-left SLT for two adult recipients. |
| first_indexed | 2024-03-11T03:03:58Z |
| format | Article |
| id | doaj.art-b2c689f23fb241d58d8c74e5cd89fb41 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T03:03:58Z |
| publishDate | 2023-05-01 |
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| spelling | doaj.art-b2c689f23fb241d58d8c74e5cd89fb412023-11-18T08:06:22ZengMDPI AGJournal of Clinical Medicine2077-03832023-05-011211378210.3390/jcm12113782Full-Right Full-Left Split Liver Transplantation for Two Adult Recipients: A Single-Center Experience in ChinaLimin Ding0Xizhi Yu1Rui Zhang2Junjie Qian3Wu Zhang4Qinchuan Wu5Lin Zhou6Zhe Yang7Shusen Zheng8Division of Hepatobiliary Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaDivision of Hepatobiliary Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaFuzhou Medical College, Nanchang University, Fuzhou 344000, ChinaDivision of Hepatobiliary Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital, Hangzhou 310022, ChinaDivision of Hepatobiliary Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaNHFPC Key Laboratory of Combined Multi-Organ Transplantation, Hangzhou 310003, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital, Hangzhou 310022, ChinaDivision of Hepatobiliary Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaBackground: The most effective treatment for end-stage liver diseases is liver transplantation, which is impeded by the shortage of donor livers. Split liver transplantation (SLT) is important for addressing the donor liver shortage. However, full-right full-left SLT for two adult recipients is globally rarely conducted. This study aimed to investigate the clinical outcomes of this technique. Methods: We retrospectively analyzed the clinical data of 22 recipients who underwent full-right full-left SLT at Shulan (Hangzhou) Hospital between January, 2021 and September, 2022. The graft-to-recipient weight ratio (GRWR), cold ischemia time, operation time, length of the anhepatic phase, intraoperative blood loss, and red blood cell transfusion amount were all analyzed. The differences in liver function recovery after transplantation were compared between the left and right hemiliver groups. The postoperative complications and prognosis of the recipients were also analyzed. Results: The livers of 11 donors were transplanted into 22 adult recipients. The GRWR ranged from 1.16–1.65%, the cold ischemia time was 282.86 ± 134.87 min, the operation time was 371.32 ± 75.36 min, the anhepatic phase lasted 60.73 ± 19.00 min, the intraoperative blood loss was 759.09 ± 316.84 mL, and the red blood cell transfusion amount was 695.45 ± 393.67 mL. No significant difference in the levels of liver function markers, total bilirubin, aspartate aminotransferase, or alanine aminotransferase between left and right hemiliver groups at 1, 3, 5, 7, 14, and 28 d postoperatively was observed (both <i>p</i> > 0.05). One recipient developed bile leakage 10 d after transplantation, which improved with endoscopic retrograde cholangiopancreatography-guided nasobiliary drainage and stent placement. Another developed portal vein thrombosis 12 d after transplantation and underwent portal vein thrombolytic therapy and stenting to restore portal vein blood flow. A color Doppler ultrasound performed 2 d after transplantation revealed hepatic artery thrombosis in one patient, and thrombolytic therapy was administered to restore hepatic artery blood flow. The liver function of other patients recovered quickly after transplantation. Conclusions: Full-right full-left SLT for two adult patients is an efficient way to increase the donor pool. It is safe and feasible with careful donor and recipient selection. Transplant hospitals with highly experienced surgeons in SLT are recommended to promote using full-right full-left SLT for two adult recipients.https://www.mdpi.com/2077-0383/12/11/3782split liver transplantationmiddle hepatic veininferior vena cavacomplete splitting and reconstruction |
| spellingShingle | Limin Ding Xizhi Yu Rui Zhang Junjie Qian Wu Zhang Qinchuan Wu Lin Zhou Zhe Yang Shusen Zheng Full-Right Full-Left Split Liver Transplantation for Two Adult Recipients: A Single-Center Experience in China Journal of Clinical Medicine split liver transplantation middle hepatic vein inferior vena cava complete splitting and reconstruction |
| title | Full-Right Full-Left Split Liver Transplantation for Two Adult Recipients: A Single-Center Experience in China |
| title_full | Full-Right Full-Left Split Liver Transplantation for Two Adult Recipients: A Single-Center Experience in China |
| title_fullStr | Full-Right Full-Left Split Liver Transplantation for Two Adult Recipients: A Single-Center Experience in China |
| title_full_unstemmed | Full-Right Full-Left Split Liver Transplantation for Two Adult Recipients: A Single-Center Experience in China |
| title_short | Full-Right Full-Left Split Liver Transplantation for Two Adult Recipients: A Single-Center Experience in China |
| title_sort | full right full left split liver transplantation for two adult recipients a single center experience in china |
| topic | split liver transplantation middle hepatic vein inferior vena cava complete splitting and reconstruction |
| url | https://www.mdpi.com/2077-0383/12/11/3782 |
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