Lonidamine potentiates the oncolytic efficiency of M1 virus independent of hexokinase 2 but via inhibition of antiviral immunity

Lonidamine potentiates the oncolytic efficiency of M1 virus independent of hexokinase 2 but via inhibition of antiviral immunity

Abstract Background Viruses are obligate parasites that depend on host cells to provide the energy and molecular precursors necessary for successful infection. The main component of virus-induced metabolic reprogramming is the activation of glycolysis, which provides biomolecular resources for viral...

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Bibliographic Details
Main Authors: Jing Cai, Wenbo Zhu, Yuan Lin, Jun Hu, Xincheng Liu, Wencang Xu, Ying Liu, Cheng Hu, Songmin He, Shoufang Gong, Guangmei Yan, Jiankai Liang
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Cancer Cell International
Subjects:
Oncolytic virus
M1 virus
Lonidamine
Glycolysis
Colorectal carcinoma
Antiviral immunity
Online Access:http://link.springer.com/article/10.1186/s12935-020-01598-w

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