The Role of Neurod Genes in Brain Development, Function, and Disease
Transcriptional regulation is essential for the correct functioning of cells during development and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is well conserved throughout evolution and plays critical roles in tissue development and tissue maintenance....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2021.662774/full |
| _version_ | 1818602879737397248 |
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| author | Svetlana Tutukova Svetlana Tutukova Victor Tarabykin Victor Tarabykin Luis R. Hernandez-Miranda |
| author_facet | Svetlana Tutukova Svetlana Tutukova Victor Tarabykin Victor Tarabykin Luis R. Hernandez-Miranda |
| author_sort | Svetlana Tutukova |
| collection | DOAJ |
| description | Transcriptional regulation is essential for the correct functioning of cells during development and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is well conserved throughout evolution and plays critical roles in tissue development and tissue maintenance. A subgroup of this family, called neural lineage bHLH factors, is critical in the development and function of the central nervous system. In this review, we will focus on the function of one subgroup of neural lineage bHLH factors, the Neurod family. The Neurod family has four members: Neurod1, Neurod2, Neurod4, and Neurod6. Available evidence shows that these four factors are key during the development of the cerebral cortex but also in other regions of the central nervous system, such as the cerebellum, the brainstem, and the spinal cord. We will also discuss recent reports that link the dysfunction of these transcription factors to neurological disorders in humans. |
| first_indexed | 2024-12-16T13:14:18Z |
| format | Article |
| id | doaj.art-b2cabd8331be4693a1f2bf2cc3e5530b |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-16T13:14:18Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-b2cabd8331be4693a1f2bf2cc3e5530b2022-12-21T22:30:32ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992021-06-011410.3389/fnmol.2021.662774662774The Role of Neurod Genes in Brain Development, Function, and DiseaseSvetlana Tutukova0Svetlana Tutukova1Victor Tarabykin2Victor Tarabykin3Luis R. Hernandez-Miranda4Institute of Neuroscience, Lobachevsky University of Nizhny Novgorod, Nizhny Novgorod, RussiaCharité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute for Cell- and Neurobiology, Berlin, GermanyInstitute of Neuroscience, Lobachevsky University of Nizhny Novgorod, Nizhny Novgorod, RussiaCharité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute for Cell- and Neurobiology, Berlin, GermanyCharité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute for Cell- and Neurobiology, Berlin, GermanyTranscriptional regulation is essential for the correct functioning of cells during development and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is well conserved throughout evolution and plays critical roles in tissue development and tissue maintenance. A subgroup of this family, called neural lineage bHLH factors, is critical in the development and function of the central nervous system. In this review, we will focus on the function of one subgroup of neural lineage bHLH factors, the Neurod family. The Neurod family has four members: Neurod1, Neurod2, Neurod4, and Neurod6. Available evidence shows that these four factors are key during the development of the cerebral cortex but also in other regions of the central nervous system, such as the cerebellum, the brainstem, and the spinal cord. We will also discuss recent reports that link the dysfunction of these transcription factors to neurological disorders in humans.https://www.frontiersin.org/articles/10.3389/fnmol.2021.662774/fullbHLH factorneurod familybrain developmentneurological diseasestranscription factors |
| spellingShingle | Svetlana Tutukova Svetlana Tutukova Victor Tarabykin Victor Tarabykin Luis R. Hernandez-Miranda The Role of Neurod Genes in Brain Development, Function, and Disease Frontiers in Molecular Neuroscience bHLH factor neurod family brain development neurological diseases transcription factors |
| title | The Role of Neurod Genes in Brain Development, Function, and Disease |
| title_full | The Role of Neurod Genes in Brain Development, Function, and Disease |
| title_fullStr | The Role of Neurod Genes in Brain Development, Function, and Disease |
| title_full_unstemmed | The Role of Neurod Genes in Brain Development, Function, and Disease |
| title_short | The Role of Neurod Genes in Brain Development, Function, and Disease |
| title_sort | role of neurod genes in brain development function and disease |
| topic | bHLH factor neurod family brain development neurological diseases transcription factors |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2021.662774/full |
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