TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer
Poly-functional helper T cells can have a stronger effect than mono-functional T cells, but whether the response is qualitatively different is not clear. Here the authors show that a population of IL-17+IL-22+, but not single IL-22+, CD4+ T cells are induced by TGF-β, enriched in patients with color...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16363-w |
| _version_ | 1818855482988691456 |
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| author | Laura Garcia Perez Jan Kempski Heather M. McGee Penelope Pelzcar Theodora Agalioti Anastasios Giannou Leonie Konczalla Leonie Brockmann Ramez Wahib Hao Xu Maria Carolina Amezcua Vesely Shiwa Soukou Babett Steglich Tanja Bedke Carolin Manthey Oliver Seiz Björn-Philipp Diercks Stylianos Gnafakis Andreas H. Guse Daniel Perez Jakob R. Izbicki Nicola Gagliani Richard A. Flavell Samuel Huber |
| author_facet | Laura Garcia Perez Jan Kempski Heather M. McGee Penelope Pelzcar Theodora Agalioti Anastasios Giannou Leonie Konczalla Leonie Brockmann Ramez Wahib Hao Xu Maria Carolina Amezcua Vesely Shiwa Soukou Babett Steglich Tanja Bedke Carolin Manthey Oliver Seiz Björn-Philipp Diercks Stylianos Gnafakis Andreas H. Guse Daniel Perez Jakob R. Izbicki Nicola Gagliani Richard A. Flavell Samuel Huber |
| author_sort | Laura Garcia Perez |
| collection | DOAJ |
| description | Poly-functional helper T cells can have a stronger effect than mono-functional T cells, but whether the response is qualitatively different is not clear. Here the authors show that a population of IL-17+IL-22+, but not single IL-22+, CD4+ T cells are induced by TGF-β, enriched in patients with colorectal cancer (CRC) and drive CRC progression in mice. |
| first_indexed | 2024-12-19T08:09:19Z |
| format | Article |
| id | doaj.art-b2cd0a9890934f83bc2a0f45b98be1cc |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:09:19Z |
| publishDate | 2020-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b2cd0a9890934f83bc2a0f45b98be1cc2022-12-21T20:29:41ZengNature PortfolioNature Communications2041-17232020-05-0111111410.1038/s41467-020-16363-wTGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancerLaura Garcia Perez0Jan Kempski1Heather M. McGee2Penelope Pelzcar3Theodora Agalioti4Anastasios Giannou5Leonie Konczalla6Leonie Brockmann7Ramez Wahib8Hao Xu9Maria Carolina Amezcua Vesely10Shiwa Soukou11Babett Steglich12Tanja Bedke13Carolin Manthey14Oliver Seiz15Björn-Philipp Diercks16Stylianos Gnafakis17Andreas H. Guse18Daniel Perez19Jakob R. Izbicki20Nicola Gagliani21Richard A. Flavell22Samuel Huber23I. Department of Medicine, University Medical Center Hamburg-EppendorfI. Department of Medicine, University Medical Center Hamburg-EppendorfCenter for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological StudiesI. Department of Medicine, University Medical Center Hamburg-EppendorfDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-EppendorfI. Department of Medicine, University Medical Center Hamburg-EppendorfDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-EppendorfDepartment of Microbiology and Immunology, Columbia UniversityDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-EppendorfDepartment of Immunobiology, School of Medicine, Yale UniversityDepartment of Immunobiology, School of Medicine, Yale UniversityI. Department of Medicine, University Medical Center Hamburg-EppendorfI. Department of Medicine, University Medical Center Hamburg-EppendorfI. Department of Medicine, University Medical Center Hamburg-EppendorfI. Department of Medicine, University Medical Center Hamburg-EppendorfI. Department of Medicine, University Medical Center Hamburg-EppendorfDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-EppendorfLaboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin BerlinDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-EppendorfDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-EppendorfDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-EppendorfI. Department of Medicine, University Medical Center Hamburg-EppendorfDepartment of Immunobiology, School of Medicine, Yale UniversityI. Department of Medicine, University Medical Center Hamburg-EppendorfPoly-functional helper T cells can have a stronger effect than mono-functional T cells, but whether the response is qualitatively different is not clear. Here the authors show that a population of IL-17+IL-22+, but not single IL-22+, CD4+ T cells are induced by TGF-β, enriched in patients with colorectal cancer (CRC) and drive CRC progression in mice.https://doi.org/10.1038/s41467-020-16363-w |
| spellingShingle | Laura Garcia Perez Jan Kempski Heather M. McGee Penelope Pelzcar Theodora Agalioti Anastasios Giannou Leonie Konczalla Leonie Brockmann Ramez Wahib Hao Xu Maria Carolina Amezcua Vesely Shiwa Soukou Babett Steglich Tanja Bedke Carolin Manthey Oliver Seiz Björn-Philipp Diercks Stylianos Gnafakis Andreas H. Guse Daniel Perez Jakob R. Izbicki Nicola Gagliani Richard A. Flavell Samuel Huber TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer Nature Communications |
| title | TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer |
| title_full | TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer |
| title_fullStr | TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer |
| title_full_unstemmed | TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer |
| title_short | TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer |
| title_sort | tgf β signaling in th17 cells promotes il 22 production and colitis associated colon cancer |
| url | https://doi.org/10.1038/s41467-020-16363-w |
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