MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis

MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis

Summary: Background: Rheumatoid arthritis (RA) is a progressive degenerative disorder that leads to joint destruction. Available treatments only target the inflammatory component with minimal impact on joint repair. We recently uncovered a previously unappreciated family of pro-resolving mediators,...

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Bibliographic Details
Main Authors: Kimberly Pistorius, Lucy Ly, Patricia R. Souza, Esteban A. Gomez, Duco S. Koenis, Ana R. Rodriguez, Julie Foster, Jane Sosabowski, Mark Hopkinson, Vinothini Rajeeve, Bernd W. Spur, Andrew Pitsillides, Costantino Pitzalis, Jesmond Dalli
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:EBioMedicine
Subjects:
SPM
Resolution
Rheumatoid arthritis
Macrophages
Tissue repair
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642200158X

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