Auditory Brainstem Response Wave I Amplitude Has Limited Clinical Utility in Diagnosing Tinnitus in Humans
Animal studies have discovered that noise, even at levels that produce no permanent threshold shift, may cause cochlear damage and selective nerve degeneration. A hallmark of such damage, or synaptopathy, is recovered threshold but reduced suprathreshold amplitude for the auditory brainstem response...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/2/142 |
| _version_ | 1797482222437007360 |
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| author | Katie Turner Omid Moshtaghi Neil Saez Matthew Richardson Hamid Djalilian Fan-Gang Zeng Harrison Lin |
| author_facet | Katie Turner Omid Moshtaghi Neil Saez Matthew Richardson Hamid Djalilian Fan-Gang Zeng Harrison Lin |
| author_sort | Katie Turner |
| collection | DOAJ |
| description | Animal studies have discovered that noise, even at levels that produce no permanent threshold shift, may cause cochlear damage and selective nerve degeneration. A hallmark of such damage, or synaptopathy, is recovered threshold but reduced suprathreshold amplitude for the auditory brainstem response (ABR) wave I. The objective of the present study is to evaluate whether the ABR wave I amplitude or slope can be used to diagnose tinnitus in humans. A total of 43 human subjects, consisting of 21 with tinnitus and 22 without tinnitus, participated in the study. The subjects were on average 44 ± 24 (standard deviation) years old and 16 were female; a subgroup of 19 were young adults with normal audiograms from 125 to 8000 Hz. The ABR was measured using ear canal recording tiptrodes for clicks, 1000, 4000 and 8000 Hz tone bursts at 30, 50, and 70 dB nHL. Compared with control subjects, tinnitus subjects did not show reduced ABR wave I amplitude or slope in either the entire group of 21 tinnitus subjects or a subset of tinnitus subjects with normal audiograms. Despite the small sample size and diverse tinnitus population, the present result suggests that low signal-to-noise ratios in non-invasive measurement of the ABR limit its clinical utility in diagnosing tinnitus in humans. |
| first_indexed | 2024-03-09T22:28:13Z |
| format | Article |
| id | doaj.art-b2cf9d666d6840558e1d864f908e02e0 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T22:28:13Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-b2cf9d666d6840558e1d864f908e02e02023-11-23T19:02:14ZengMDPI AGBrain Sciences2076-34252022-01-0112214210.3390/brainsci12020142Auditory Brainstem Response Wave I Amplitude Has Limited Clinical Utility in Diagnosing Tinnitus in HumansKatie Turner0Omid Moshtaghi1Neil Saez2Matthew Richardson3Hamid Djalilian4Fan-Gang Zeng5Harrison Lin6Department of Otolaryngology, Head & Neck Surgery, University of California Irvine, Irvine, CA 92697-5320, USADepartment of Otolaryngology, Head & Neck Surgery, University of California Irvine, Irvine, CA 92697-5320, USADepartment of Otolaryngology, Head & Neck Surgery, University of California Irvine, Irvine, CA 92697-5320, USADepartment of Otolaryngology, Head & Neck Surgery, University of California Irvine, Irvine, CA 92697-5320, USADepartment of Otolaryngology, Head & Neck Surgery, University of California Irvine, Irvine, CA 92697-5320, USADepartment of Otolaryngology, Head & Neck Surgery, University of California Irvine, Irvine, CA 92697-5320, USADepartment of Otolaryngology, Head & Neck Surgery, University of California Irvine, Irvine, CA 92697-5320, USAAnimal studies have discovered that noise, even at levels that produce no permanent threshold shift, may cause cochlear damage and selective nerve degeneration. A hallmark of such damage, or synaptopathy, is recovered threshold but reduced suprathreshold amplitude for the auditory brainstem response (ABR) wave I. The objective of the present study is to evaluate whether the ABR wave I amplitude or slope can be used to diagnose tinnitus in humans. A total of 43 human subjects, consisting of 21 with tinnitus and 22 without tinnitus, participated in the study. The subjects were on average 44 ± 24 (standard deviation) years old and 16 were female; a subgroup of 19 were young adults with normal audiograms from 125 to 8000 Hz. The ABR was measured using ear canal recording tiptrodes for clicks, 1000, 4000 and 8000 Hz tone bursts at 30, 50, and 70 dB nHL. Compared with control subjects, tinnitus subjects did not show reduced ABR wave I amplitude or slope in either the entire group of 21 tinnitus subjects or a subset of tinnitus subjects with normal audiograms. Despite the small sample size and diverse tinnitus population, the present result suggests that low signal-to-noise ratios in non-invasive measurement of the ABR limit its clinical utility in diagnosing tinnitus in humans.https://www.mdpi.com/2076-3425/12/2/142tinnitusauditory brainstem responsebiomarkerhuman |
| spellingShingle | Katie Turner Omid Moshtaghi Neil Saez Matthew Richardson Hamid Djalilian Fan-Gang Zeng Harrison Lin Auditory Brainstem Response Wave I Amplitude Has Limited Clinical Utility in Diagnosing Tinnitus in Humans Brain Sciences tinnitus auditory brainstem response biomarker human |
| title | Auditory Brainstem Response Wave I Amplitude Has Limited Clinical Utility in Diagnosing Tinnitus in Humans |
| title_full | Auditory Brainstem Response Wave I Amplitude Has Limited Clinical Utility in Diagnosing Tinnitus in Humans |
| title_fullStr | Auditory Brainstem Response Wave I Amplitude Has Limited Clinical Utility in Diagnosing Tinnitus in Humans |
| title_full_unstemmed | Auditory Brainstem Response Wave I Amplitude Has Limited Clinical Utility in Diagnosing Tinnitus in Humans |
| title_short | Auditory Brainstem Response Wave I Amplitude Has Limited Clinical Utility in Diagnosing Tinnitus in Humans |
| title_sort | auditory brainstem response wave i amplitude has limited clinical utility in diagnosing tinnitus in humans |
| topic | tinnitus auditory brainstem response biomarker human |
| url | https://www.mdpi.com/2076-3425/12/2/142 |
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