Molecular Mechanisms, Epidemiology, and Clinical Importance of β-Lactam Resistance in <i>Enterobacteriaceae</i>
Despite being members of gut microbiota, <i>Enterobacteriaceae</i> are associated with many severe infections such as bloodstream infections. The β-lactam drugs have been the cornerstone of antibiotic therapy for such infections. However, the overuse of these antibiotics has contributed...
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| Format: | Article |
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MDPI AG
2020-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/14/5090 |
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| author | Giulia De Angelis Paola Del Giacomo Brunella Posteraro Maurizio Sanguinetti Mario Tumbarello |
| author_facet | Giulia De Angelis Paola Del Giacomo Brunella Posteraro Maurizio Sanguinetti Mario Tumbarello |
| author_sort | Giulia De Angelis |
| collection | DOAJ |
| description | Despite being members of gut microbiota, <i>Enterobacteriaceae</i> are associated with many severe infections such as bloodstream infections. The β-lactam drugs have been the cornerstone of antibiotic therapy for such infections. However, the overuse of these antibiotics has contributed to select β-lactam-resistant <i>Enterobacteriaceae</i> isolates, so that β-lactam resistance is nowadays a major concern worldwide. The production of enzymes that inactivate β-lactams, mainly extended-spectrum β-lactamases and carbapenemases, can confer multidrug resistance patterns that seriously compromise therapeutic options. Further, β-lactam resistance may result in increases in the drug toxicity, mortality, and healthcare costs associated with <i>Enterobacteriaceae</i> infections. Here, we summarize the updated evidence about the molecular mechanisms and epidemiology of β-lactamase-mediated β-lactam resistance in <i>Enterobacteriaceae</i>, and their potential impact on clinical outcomes of β-lactam-resistant <i>Enterobacteriaceae</i> infections. |
| first_indexed | 2024-03-10T18:23:01Z |
| format | Article |
| id | doaj.art-b2cffca36e0b4b82a2ac383c5baa2203 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:23:01Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b2cffca36e0b4b82a2ac383c5baa22032023-11-20T07:13:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-012114509010.3390/ijms21145090Molecular Mechanisms, Epidemiology, and Clinical Importance of β-Lactam Resistance in <i>Enterobacteriaceae</i>Giulia De Angelis0Paola Del Giacomo1Brunella Posteraro2Maurizio Sanguinetti3Mario Tumbarello4Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDespite being members of gut microbiota, <i>Enterobacteriaceae</i> are associated with many severe infections such as bloodstream infections. The β-lactam drugs have been the cornerstone of antibiotic therapy for such infections. However, the overuse of these antibiotics has contributed to select β-lactam-resistant <i>Enterobacteriaceae</i> isolates, so that β-lactam resistance is nowadays a major concern worldwide. The production of enzymes that inactivate β-lactams, mainly extended-spectrum β-lactamases and carbapenemases, can confer multidrug resistance patterns that seriously compromise therapeutic options. Further, β-lactam resistance may result in increases in the drug toxicity, mortality, and healthcare costs associated with <i>Enterobacteriaceae</i> infections. Here, we summarize the updated evidence about the molecular mechanisms and epidemiology of β-lactamase-mediated β-lactam resistance in <i>Enterobacteriaceae</i>, and their potential impact on clinical outcomes of β-lactam-resistant <i>Enterobacteriaceae</i> infections.https://www.mdpi.com/1422-0067/21/14/5090<i>Enterobacteriaceae</i>β-lactamaseβ-lactam drugsmolecular resistance |
| spellingShingle | Giulia De Angelis Paola Del Giacomo Brunella Posteraro Maurizio Sanguinetti Mario Tumbarello Molecular Mechanisms, Epidemiology, and Clinical Importance of β-Lactam Resistance in <i>Enterobacteriaceae</i> International Journal of Molecular Sciences <i>Enterobacteriaceae</i> β-lactamase β-lactam drugs molecular resistance |
| title | Molecular Mechanisms, Epidemiology, and Clinical Importance of β-Lactam Resistance in <i>Enterobacteriaceae</i> |
| title_full | Molecular Mechanisms, Epidemiology, and Clinical Importance of β-Lactam Resistance in <i>Enterobacteriaceae</i> |
| title_fullStr | Molecular Mechanisms, Epidemiology, and Clinical Importance of β-Lactam Resistance in <i>Enterobacteriaceae</i> |
| title_full_unstemmed | Molecular Mechanisms, Epidemiology, and Clinical Importance of β-Lactam Resistance in <i>Enterobacteriaceae</i> |
| title_short | Molecular Mechanisms, Epidemiology, and Clinical Importance of β-Lactam Resistance in <i>Enterobacteriaceae</i> |
| title_sort | molecular mechanisms epidemiology and clinical importance of β lactam resistance in i enterobacteriaceae i |
| topic | <i>Enterobacteriaceae</i> β-lactamase β-lactam drugs molecular resistance |
| url | https://www.mdpi.com/1422-0067/21/14/5090 |
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