Experimental murine schistosomiasis mansoni: estabilishment of the chronic phase of the disease
After the acute hyperergic phase of schistosomal infection, the chronic phase of the disease corresponds to the estabilishment of a relative equilibrium between the host and the parasite. This involves: (1) A shift from the predominance of the TH2 response observed in the acute phase, to the predomi...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
1992-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000800026 |
| _version_ | 1797718465748926464 |
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| author | Radovan Borojevic |
| author_facet | Radovan Borojevic |
| author_sort | Radovan Borojevic |
| collection | DOAJ |
| description | After the acute hyperergic phase of schistosomal infection, the chronic phase of the disease corresponds to the estabilishment of a relative equilibrium between the host and the parasite. This involves: (1) A shift from the predominance of the TH2 response observed in the acute phase, to the predominance of the TH1 response in the chronic phase of the disease, with modification of lymphokine and immunoglobulin secretions patterns. (2) Redistribution of hosts responses to parasite, with predominance of systemic controls in the acute phase, and a shift towards local tissue responses in the chronic phase. This redistribution relieves the hyperergic responses involving the whole body of the host, and delimits cellular and molecular reactions to parasites to only those tissues that are directly involved by the adult parasites and their eggs. Mobilization of eosinophil granulocytes in schistosomal periovular granulomas is one of examples of this redistribution. |
| first_indexed | 2024-03-12T08:52:12Z |
| format | Article |
| id | doaj.art-b2d0e0d4cd5543f781e65329a4981790 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:52:12Z |
| publishDate | 1992-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-b2d0e0d4cd5543f781e65329a49817902023-09-02T16:17:54ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601992-01-018717117410.1590/S0074-02761992000800026Experimental murine schistosomiasis mansoni: estabilishment of the chronic phase of the diseaseRadovan BorojevicAfter the acute hyperergic phase of schistosomal infection, the chronic phase of the disease corresponds to the estabilishment of a relative equilibrium between the host and the parasite. This involves: (1) A shift from the predominance of the TH2 response observed in the acute phase, to the predominance of the TH1 response in the chronic phase of the disease, with modification of lymphokine and immunoglobulin secretions patterns. (2) Redistribution of hosts responses to parasite, with predominance of systemic controls in the acute phase, and a shift towards local tissue responses in the chronic phase. This redistribution relieves the hyperergic responses involving the whole body of the host, and delimits cellular and molecular reactions to parasites to only those tissues that are directly involved by the adult parasites and their eggs. Mobilization of eosinophil granulocytes in schistosomal periovular granulomas is one of examples of this redistribution.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000800026schistosomiasis mansonimiceimmune regulations |
| spellingShingle | Radovan Borojevic Experimental murine schistosomiasis mansoni: estabilishment of the chronic phase of the disease Memorias do Instituto Oswaldo Cruz schistosomiasis mansoni mice immune regulations |
| title | Experimental murine schistosomiasis mansoni: estabilishment of the chronic phase of the disease |
| title_full | Experimental murine schistosomiasis mansoni: estabilishment of the chronic phase of the disease |
| title_fullStr | Experimental murine schistosomiasis mansoni: estabilishment of the chronic phase of the disease |
| title_full_unstemmed | Experimental murine schistosomiasis mansoni: estabilishment of the chronic phase of the disease |
| title_short | Experimental murine schistosomiasis mansoni: estabilishment of the chronic phase of the disease |
| title_sort | experimental murine schistosomiasis mansoni estabilishment of the chronic phase of the disease |
| topic | schistosomiasis mansoni mice immune regulations |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000800026 |
| work_keys_str_mv | AT radovanborojevic experimentalmurineschistosomiasismansoniestabilishmentofthechronicphaseofthedisease |