Wellens’ syndrome following severe COVID-19 infection, an innocent coincidence or a deadly association: two case reports
Abstract Background Coronavirus disease 2019 (COVID-19) has been associated with late-onset cardiovascular complications primarily due to a hypercoagulable state. Its association with Wellens’ syndrome, which reflects a stenosis in the proximal left anterior descending coronary artery, is not well e...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-02-01
|
| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-023-03137-7 |
| _version_ | 1797865624859312128 |
|---|---|
| author | Georges Khattar Jennifer Hallit Carolla El Chamieh Elie Bou Sanayeh |
| author_facet | Georges Khattar Jennifer Hallit Carolla El Chamieh Elie Bou Sanayeh |
| author_sort | Georges Khattar |
| collection | DOAJ |
| description | Abstract Background Coronavirus disease 2019 (COVID-19) has been associated with late-onset cardiovascular complications primarily due to a hypercoagulable state. Its association with Wellens’ syndrome, which reflects a stenosis in the proximal left anterior descending coronary artery, is not well established. We present two cases diagnosed with this syndrome following their COVID-19 acute phase despite taking adequate anticoagulation. Case presentation We present two patients with incidental electrocardiography (ECG) showing the typical Wellens’-related changes, with an underlying severe triple-vessel coronary artery disease a few weeks following a severe COVID-19 infection associated with high inflammatory markers. The stenotic lesions were diagnosed by cardiac catheterization, and both patients underwent Coronary Artery Bypass Grafting successfully. Notably, patients’ baseline ECGs were normal, and they were maintained on Rivaroxaban 10 mg following their viral illness. Conclusion Despite advances in the preventive measures for COVID-19 complications, its pathophysiologic impact on vasculature and atherosclerosis is still incompletely understood. Further clinical trials must be conducted to study this association between Wellens’ syndrome and this virus to prevent life-threatening complications. |
| first_indexed | 2024-04-09T23:12:14Z |
| format | Article |
| id | doaj.art-b2d152f9386e4f9b8a971094fe65f92c |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-09T23:12:14Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-b2d152f9386e4f9b8a971094fe65f92c2023-03-22T10:22:25ZengBMCBMC Cardiovascular Disorders1471-22612023-02-012311610.1186/s12872-023-03137-7Wellens’ syndrome following severe COVID-19 infection, an innocent coincidence or a deadly association: two case reportsGeorges Khattar0Jennifer Hallit1Carolla El Chamieh2Elie Bou Sanayeh3Faculty of Medicine and Medical Sciences, Holy Spirit University of Kaslik (USEK)Department of Pediatrics, American University of Beirut Medical CenterFaculty of Medicine and Medical Sciences, Holy Spirit University of Kaslik (USEK)Department of Internal Medicine, American University of Beirut Medical CenterAbstract Background Coronavirus disease 2019 (COVID-19) has been associated with late-onset cardiovascular complications primarily due to a hypercoagulable state. Its association with Wellens’ syndrome, which reflects a stenosis in the proximal left anterior descending coronary artery, is not well established. We present two cases diagnosed with this syndrome following their COVID-19 acute phase despite taking adequate anticoagulation. Case presentation We present two patients with incidental electrocardiography (ECG) showing the typical Wellens’-related changes, with an underlying severe triple-vessel coronary artery disease a few weeks following a severe COVID-19 infection associated with high inflammatory markers. The stenotic lesions were diagnosed by cardiac catheterization, and both patients underwent Coronary Artery Bypass Grafting successfully. Notably, patients’ baseline ECGs were normal, and they were maintained on Rivaroxaban 10 mg following their viral illness. Conclusion Despite advances in the preventive measures for COVID-19 complications, its pathophysiologic impact on vasculature and atherosclerosis is still incompletely understood. Further clinical trials must be conducted to study this association between Wellens’ syndrome and this virus to prevent life-threatening complications.https://doi.org/10.1186/s12872-023-03137-7COVID-19Wellens’ syndromeAcute coronary syndromeAtherosclerosisCOVID-19 complications |
| spellingShingle | Georges Khattar Jennifer Hallit Carolla El Chamieh Elie Bou Sanayeh Wellens’ syndrome following severe COVID-19 infection, an innocent coincidence or a deadly association: two case reports BMC Cardiovascular Disorders COVID-19 Wellens’ syndrome Acute coronary syndrome Atherosclerosis COVID-19 complications |
| title | Wellens’ syndrome following severe COVID-19 infection, an innocent coincidence or a deadly association: two case reports |
| title_full | Wellens’ syndrome following severe COVID-19 infection, an innocent coincidence or a deadly association: two case reports |
| title_fullStr | Wellens’ syndrome following severe COVID-19 infection, an innocent coincidence or a deadly association: two case reports |
| title_full_unstemmed | Wellens’ syndrome following severe COVID-19 infection, an innocent coincidence or a deadly association: two case reports |
| title_short | Wellens’ syndrome following severe COVID-19 infection, an innocent coincidence or a deadly association: two case reports |
| title_sort | wellens syndrome following severe covid 19 infection an innocent coincidence or a deadly association two case reports |
| topic | COVID-19 Wellens’ syndrome Acute coronary syndrome Atherosclerosis COVID-19 complications |
| url | https://doi.org/10.1186/s12872-023-03137-7 |
| work_keys_str_mv | AT georgeskhattar wellenssyndromefollowingseverecovid19infectionaninnocentcoincidenceoradeadlyassociationtwocasereports AT jenniferhallit wellenssyndromefollowingseverecovid19infectionaninnocentcoincidenceoradeadlyassociationtwocasereports AT carollaelchamieh wellenssyndromefollowingseverecovid19infectionaninnocentcoincidenceoradeadlyassociationtwocasereports AT eliebousanayeh wellenssyndromefollowingseverecovid19infectionaninnocentcoincidenceoradeadlyassociationtwocasereports |