An in vivo study of isotropic and anisotropic wall stress in a hyperelastic holzapfel-gasser-ogden model in the human abdominal aorta: Effects of age and sex
Background: Wall stress of the abdominal aorta (AA) appears to be an important factor in the assessment of risk for rupture based on the relationship between blood pressure and aortic diameter. We therefore investigated peak wall stress as well as isotropic and anisotropic wall stress of AA.Methods:...
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1128131/full |
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| author | Jerker Karlsson Jonas Stålhand Carl-Johan Carlhäll Carl-Johan Carlhäll Toste Länne Toste Länne Jan Engvall Jan Engvall |
| author_facet | Jerker Karlsson Jonas Stålhand Carl-Johan Carlhäll Carl-Johan Carlhäll Toste Länne Toste Länne Jan Engvall Jan Engvall |
| author_sort | Jerker Karlsson |
| collection | DOAJ |
| description | Background: Wall stress of the abdominal aorta (AA) appears to be an important factor in the assessment of risk for rupture based on the relationship between blood pressure and aortic diameter. We therefore investigated peak wall stress as well as isotropic and anisotropic wall stress of AA.Methods: Thirty healthy adults (male = 15) were included. Pulsatile diameter changes were determined non-invasively by an echo-tracking system, and intra-aortic pressure was measured simultaneously. A computer based mechanical model was used to compute the isotropic and anisotropic components of circumferential and longitudinal stresses.Results: Elderly males had higher total wall stress and a higher isotropic stress component in the circumferential direction and higher total longitudinal wall stress than elderly females. The isotropic component increased with age in males but not in females, whereas the anisotropic component decreased with age in both sexes.Conclusion: We found that isotropic and anisotropic properties of the abdominal aortic wall differ between young and elderly participants and between the sexes. A possible explanation could relate to chemical alterations (e.g., due to sex hormones) and changes over time in the physical distribution of fibers. Modeling of wall stress components of the human AA may contribute to a better understanding of elastin-collagen interactions during remodeling of the aortic wall. |
| first_indexed | 2024-04-10T04:06:09Z |
| format | Article |
| id | doaj.art-b2d3ce37842d4cb68b045e8ae0c4572d |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-10T04:06:09Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-b2d3ce37842d4cb68b045e8ae0c4572d2023-03-13T05:56:59ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-03-011410.3389/fphys.2023.11281311128131An in vivo study of isotropic and anisotropic wall stress in a hyperelastic holzapfel-gasser-ogden model in the human abdominal aorta: Effects of age and sexJerker Karlsson0Jonas Stålhand1Carl-Johan Carlhäll2Carl-Johan Carlhäll3Toste Länne4Toste Länne5Jan Engvall6Jan Engvall7Department of Clinical Physiology in Linköping, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, SwedenSolid Mechanics, Department of Management and Engineering, Linköping University, Linköping, SwedenDepartment of Clinical Physiology in Linköping, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, SwedenCenter for Medical Image Science and Visualization, Linköping University, Linköping, SwedenCenter for Medical Image Science and Visualization, Linköping University, Linköping, SwedenDepartment of Thoracic and Vascular Surgery in Linköping, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, SwedenDepartment of Clinical Physiology in Linköping, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, SwedenCenter for Medical Image Science and Visualization, Linköping University, Linköping, SwedenBackground: Wall stress of the abdominal aorta (AA) appears to be an important factor in the assessment of risk for rupture based on the relationship between blood pressure and aortic diameter. We therefore investigated peak wall stress as well as isotropic and anisotropic wall stress of AA.Methods: Thirty healthy adults (male = 15) were included. Pulsatile diameter changes were determined non-invasively by an echo-tracking system, and intra-aortic pressure was measured simultaneously. A computer based mechanical model was used to compute the isotropic and anisotropic components of circumferential and longitudinal stresses.Results: Elderly males had higher total wall stress and a higher isotropic stress component in the circumferential direction and higher total longitudinal wall stress than elderly females. The isotropic component increased with age in males but not in females, whereas the anisotropic component decreased with age in both sexes.Conclusion: We found that isotropic and anisotropic properties of the abdominal aortic wall differ between young and elderly participants and between the sexes. A possible explanation could relate to chemical alterations (e.g., due to sex hormones) and changes over time in the physical distribution of fibers. Modeling of wall stress components of the human AA may contribute to a better understanding of elastin-collagen interactions during remodeling of the aortic wall.https://www.frontiersin.org/articles/10.3389/fphys.2023.1128131/fullabdominal aortaremodelingwall stresssexage |
| spellingShingle | Jerker Karlsson Jonas Stålhand Carl-Johan Carlhäll Carl-Johan Carlhäll Toste Länne Toste Länne Jan Engvall Jan Engvall An in vivo study of isotropic and anisotropic wall stress in a hyperelastic holzapfel-gasser-ogden model in the human abdominal aorta: Effects of age and sex Frontiers in Physiology abdominal aorta remodeling wall stress sex age |
| title | An in vivo study of isotropic and anisotropic wall stress in a hyperelastic holzapfel-gasser-ogden model in the human abdominal aorta: Effects of age and sex |
| title_full | An in vivo study of isotropic and anisotropic wall stress in a hyperelastic holzapfel-gasser-ogden model in the human abdominal aorta: Effects of age and sex |
| title_fullStr | An in vivo study of isotropic and anisotropic wall stress in a hyperelastic holzapfel-gasser-ogden model in the human abdominal aorta: Effects of age and sex |
| title_full_unstemmed | An in vivo study of isotropic and anisotropic wall stress in a hyperelastic holzapfel-gasser-ogden model in the human abdominal aorta: Effects of age and sex |
| title_short | An in vivo study of isotropic and anisotropic wall stress in a hyperelastic holzapfel-gasser-ogden model in the human abdominal aorta: Effects of age and sex |
| title_sort | in vivo study of isotropic and anisotropic wall stress in a hyperelastic holzapfel gasser ogden model in the human abdominal aorta effects of age and sex |
| topic | abdominal aorta remodeling wall stress sex age |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1128131/full |
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