Tauroursodeoxycholic acid functions as a critical effector mediating insulin sensitization of metformin in obese mice

Tauroursodeoxycholic acid functions as a critical effector mediating insulin sensitization of metformin in obese mice

Metformin is widely used to surmount insulin resistance (IR) and type 2 diabetes. Accumulating evidence suggests that metformin may improve IR through regulating gut microbiota and bile acids. However, the underlying mechanisms remain unclear. Our metabolomic analysis showed that metformin significa...

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Bibliographic Details
Main Authors: Ya Zhang, Yang Cheng, Jian Liu, Jihui Zuo, Liping Yan, Ronald W. Thring, Xueqing Ba, Dake Qi, Mingjiang Wu, Yitian Gao, Haibin Tong
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Redox Biology
Subjects:
Metformin
Insulin resistance
Tauroursodeoxycholic acid
Nrf2
Bile salt hydrolase
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722002531

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