Diazoxide is a powerful cardioprotectant but is not feasible in a realistic infarct scenario

Diazoxide is a powerful cardioprotectant but is not feasible in a realistic infarct scenario

IntroductionDiazoxide is a powerful cardioprotective agent that activates mitochondrial ATP-dependent K-channels and stimulates mitochondrial respiration. Diazoxide reduced infarct size in isolated rodent heart preparations and upon pretreatment in juvenile pigs with coronary occlusion/reperfusion....

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Bibliographic Details
Main Authors:	Petra Kleinbongard, Helmut Lieder, Andreas Skyschally, Gerd Heusch
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-04-01
Series:	Frontiers in Cardiovascular Medicine
Subjects:	cardioprotection coronary microvascular obstruction diazoxide infarct size myocardial infarction reperfusion
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2023.1173462/full

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