Capturing the Biologic Onset of Inflammatory Bowel Diseases: Impact on Translational and Clinical Science
While much progress has been made in the last two decades in the treatment and the management of inflammatory bowel diseases (IBD)—both ulcerative colitis (UC) and Crohn’s Disease (CD)—as of today these conditions are still diagnosed only after they have become symptoma...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/6/548 |
| _version_ | 1797707074027651072 |
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| author | Dario Sorrentino Vu Q. Nguyen Maithili V. Chitnavis |
| author_facet | Dario Sorrentino Vu Q. Nguyen Maithili V. Chitnavis |
| author_sort | Dario Sorrentino |
| collection | DOAJ |
| description | While much progress has been made in the last two decades in the treatment and the management of inflammatory bowel diseases (IBD)—both ulcerative colitis (UC) and Crohn’s Disease (CD)—as of today these conditions are still diagnosed only after they have become symptomatic. This is a major drawback since by then the inflammatory process has often already caused considerable damage and the disease might have become partially or totally unresponsive to medical therapy. Late diagnosis in IBD is due to the lack of accurate, non-invasive indicators that would allow disease identification during the pre-clinical stage—as it is often done in many other medical conditions. Here, we will discuss what is known about the biologic onset and pre-clinical CD with an emphasis on studies conducted in patients’ first degree relatives. We will then review the possible strategies to diagnose IBD very early in time including screening, available disease markers and imaging, and the possible clinical implications of treating these conditions at or close to their biologic onset. Later, we will review the potential impact of conducting translational research in IBD during the pre-clinical stage, especially focusing on the role of the microbiome in disease etiology and pathogenesis. Finally, we will highlight possible future developments in the field and how they can impact IBD management and our scientific knowledge of these conditions. |
| first_indexed | 2024-03-12T06:01:01Z |
| format | Article |
| id | doaj.art-b2d55e1264254eaa9fbb43cbfa75f2ad |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T06:01:01Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-b2d55e1264254eaa9fbb43cbfa75f2ad2023-09-03T04:08:10ZengMDPI AGCells2073-44092019-06-018654810.3390/cells8060548cells8060548Capturing the Biologic Onset of Inflammatory Bowel Diseases: Impact on Translational and Clinical ScienceDario Sorrentino0Vu Q. Nguyen1Maithili V. Chitnavis2IBD Center, Division of Gastroenterology, Virginia Tech Carilion School of Medicine, FRACP 3 Riverside Circle, Roanoke, VA 24016, USAIBD Center, Division of Gastroenterology, Virginia Tech Carilion School of Medicine, FRACP 3 Riverside Circle, Roanoke, VA 24016, USAIBD Center, Division of Gastroenterology, Virginia Tech Carilion School of Medicine, FRACP 3 Riverside Circle, Roanoke, VA 24016, USAWhile much progress has been made in the last two decades in the treatment and the management of inflammatory bowel diseases (IBD)—both ulcerative colitis (UC) and Crohn’s Disease (CD)—as of today these conditions are still diagnosed only after they have become symptomatic. This is a major drawback since by then the inflammatory process has often already caused considerable damage and the disease might have become partially or totally unresponsive to medical therapy. Late diagnosis in IBD is due to the lack of accurate, non-invasive indicators that would allow disease identification during the pre-clinical stage—as it is often done in many other medical conditions. Here, we will discuss what is known about the biologic onset and pre-clinical CD with an emphasis on studies conducted in patients’ first degree relatives. We will then review the possible strategies to diagnose IBD very early in time including screening, available disease markers and imaging, and the possible clinical implications of treating these conditions at or close to their biologic onset. Later, we will review the potential impact of conducting translational research in IBD during the pre-clinical stage, especially focusing on the role of the microbiome in disease etiology and pathogenesis. Finally, we will highlight possible future developments in the field and how they can impact IBD management and our scientific knowledge of these conditions.https://www.mdpi.com/2073-4409/8/6/548pre-clinical diseaseCrohn’s diseaseulcerative colitisbiologic onsetdisease markersscreeningmicrobiomeearly diagnosis |
| spellingShingle | Dario Sorrentino Vu Q. Nguyen Maithili V. Chitnavis Capturing the Biologic Onset of Inflammatory Bowel Diseases: Impact on Translational and Clinical Science Cells pre-clinical disease Crohn’s disease ulcerative colitis biologic onset disease markers screening microbiome early diagnosis |
| title | Capturing the Biologic Onset of Inflammatory Bowel Diseases: Impact on Translational and Clinical Science |
| title_full | Capturing the Biologic Onset of Inflammatory Bowel Diseases: Impact on Translational and Clinical Science |
| title_fullStr | Capturing the Biologic Onset of Inflammatory Bowel Diseases: Impact on Translational and Clinical Science |
| title_full_unstemmed | Capturing the Biologic Onset of Inflammatory Bowel Diseases: Impact on Translational and Clinical Science |
| title_short | Capturing the Biologic Onset of Inflammatory Bowel Diseases: Impact on Translational and Clinical Science |
| title_sort | capturing the biologic onset of inflammatory bowel diseases impact on translational and clinical science |
| topic | pre-clinical disease Crohn’s disease ulcerative colitis biologic onset disease markers screening microbiome early diagnosis |
| url | https://www.mdpi.com/2073-4409/8/6/548 |
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