Exercise training modalities in prediabetes: a systematic review and network meta-analysis
BackgroundLifestyle modification based on exercise intervention is still the primary way to delay or reverse the development of diabetes in patients with prediabetes. However, there are still challenges in setting up a detailed exercise prescription for people with prediabetes. This study mainly ran...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1308959/full |
| _version_ | 1797302890422861824 |
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| author | Hang Zhang Yuting Guo Guangshun Hua Chenyang Guo Simiao Gong Min Li Yan Yang |
| author_facet | Hang Zhang Yuting Guo Guangshun Hua Chenyang Guo Simiao Gong Min Li Yan Yang |
| author_sort | Hang Zhang |
| collection | DOAJ |
| description | BackgroundLifestyle modification based on exercise intervention is still the primary way to delay or reverse the development of diabetes in patients with prediabetes. However, there are still challenges in setting up a detailed exercise prescription for people with prediabetes. This study mainly ranks exercise prescriptions by comparing the improvement of glucose and lipid metabolism and the level of weight loss in patients.MethodAll studies on exercise intervention in prediabetes were identified by searching five electronic databases. Risk assessment and meta-analysis were performed on eligible studies.ResultsTwenty-four studies involving 1946 patients with prediabetes and seven exercise intervention models were included in the final analysis. The meta-analysis showed that exercise of any type was more effective for glycemic control in prediabetes than no exercise. However, the changes in blood glucose were moderate. In prediabetes, combining moderate-intensity aerobic exercise with low-to moderate-load resistance training showed the most significant improvements in glycosylated hemoglobin (HbA1c), body mass index (BMI), body weight (BW), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL) (P-score=0.82; 0.70; 0.87; 1; 0.99), low-to moderate-load resistance training showed the most significant improvements in fasting blood glucose (FBG) (P-score=0.98), the vigorous-intensity aerobic exercise showed the most significant improvements in 2-hour post-meal blood glucose (2hPG) and systolic blood pressure (SBP) (P-score=0.79; 0.78), and moderate-intensity aerobic exercise showed the most significant improvements in diastolic blood pressure (DBP) (P-score=0.78).ConclusionIn summary, moderate-intensity aerobic exercise, low-to moderate-load resistance training and the combination of both have beneficial effects on glycemic control, weight loss, and cardiovascular health in patients with prediabetes. These findings provide valuable guidance for rehabilitation clinicians and patients alike to follow.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD 42021284922. |
| first_indexed | 2024-03-07T23:44:31Z |
| format | Article |
| id | doaj.art-b2d5fa70268540cfafea2de369525000 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-07T23:44:31Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-b2d5fa70268540cfafea2de3695250002024-02-19T16:47:51ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-02-011510.3389/fendo.2024.13089591308959Exercise training modalities in prediabetes: a systematic review and network meta-analysisHang Zhang0Yuting Guo1Guangshun Hua2Chenyang Guo3Simiao Gong4Min Li5Yan Yang6School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Rehabilitation Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong, ChinaSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaMedical Department of The Third Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaBackgroundLifestyle modification based on exercise intervention is still the primary way to delay or reverse the development of diabetes in patients with prediabetes. However, there are still challenges in setting up a detailed exercise prescription for people with prediabetes. This study mainly ranks exercise prescriptions by comparing the improvement of glucose and lipid metabolism and the level of weight loss in patients.MethodAll studies on exercise intervention in prediabetes were identified by searching five electronic databases. Risk assessment and meta-analysis were performed on eligible studies.ResultsTwenty-four studies involving 1946 patients with prediabetes and seven exercise intervention models were included in the final analysis. The meta-analysis showed that exercise of any type was more effective for glycemic control in prediabetes than no exercise. However, the changes in blood glucose were moderate. In prediabetes, combining moderate-intensity aerobic exercise with low-to moderate-load resistance training showed the most significant improvements in glycosylated hemoglobin (HbA1c), body mass index (BMI), body weight (BW), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL) (P-score=0.82; 0.70; 0.87; 1; 0.99), low-to moderate-load resistance training showed the most significant improvements in fasting blood glucose (FBG) (P-score=0.98), the vigorous-intensity aerobic exercise showed the most significant improvements in 2-hour post-meal blood glucose (2hPG) and systolic blood pressure (SBP) (P-score=0.79; 0.78), and moderate-intensity aerobic exercise showed the most significant improvements in diastolic blood pressure (DBP) (P-score=0.78).ConclusionIn summary, moderate-intensity aerobic exercise, low-to moderate-load resistance training and the combination of both have beneficial effects on glycemic control, weight loss, and cardiovascular health in patients with prediabetes. These findings provide valuable guidance for rehabilitation clinicians and patients alike to follow.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD 42021284922.https://www.frontiersin.org/articles/10.3389/fendo.2024.1308959/fullexerciseprediabetic stateglycemic controlweight losscardiovascular risk factorsnetwork meta-analysis |
| spellingShingle | Hang Zhang Yuting Guo Guangshun Hua Chenyang Guo Simiao Gong Min Li Yan Yang Exercise training modalities in prediabetes: a systematic review and network meta-analysis Frontiers in Endocrinology exercise prediabetic state glycemic control weight loss cardiovascular risk factors network meta-analysis |
| title | Exercise training modalities in prediabetes: a systematic review and network meta-analysis |
| title_full | Exercise training modalities in prediabetes: a systematic review and network meta-analysis |
| title_fullStr | Exercise training modalities in prediabetes: a systematic review and network meta-analysis |
| title_full_unstemmed | Exercise training modalities in prediabetes: a systematic review and network meta-analysis |
| title_short | Exercise training modalities in prediabetes: a systematic review and network meta-analysis |
| title_sort | exercise training modalities in prediabetes a systematic review and network meta analysis |
| topic | exercise prediabetic state glycemic control weight loss cardiovascular risk factors network meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1308959/full |
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