Targeting Ferroptosis in Colorectal Cancer
Ferroptosis is a unique way of regulating cell death (RCD), which is quite different from other programmed cell deaths such as autophagy. It presents iron overload, accumulation of reactive oxygen species (ROS), and lipid peroxidation. A ferroptotic cell usually has an intact cell structure as well...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/8/745 |
| _version_ | 1797443514026426368 |
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| author | Xiaojie Liang Zhihuan You Xinhao Chen Jun Li |
| author_facet | Xiaojie Liang Zhihuan You Xinhao Chen Jun Li |
| author_sort | Xiaojie Liang |
| collection | DOAJ |
| description | Ferroptosis is a unique way of regulating cell death (RCD), which is quite different from other programmed cell deaths such as autophagy. It presents iron overload, accumulation of reactive oxygen species (ROS), and lipid peroxidation. A ferroptotic cell usually has an intact cell structure as well as shrinking mitochondria with decreased or vanishing cristae, concentrated membrane density, and ruptured outer membrane. Recently, increasing investigations have discovered that tumor cells have a much greater iron demand than the normal ones, making them more sensitive to ferroptosis. In other words, ferroptosis may inhibit the progress of the tumor, which can be used in the therapy of tumor patients, especially for those with chemotherapy resistance. Therefore, ferroptosis has become one hot spot in the field of tumor research in recent years. Colorectal cancer (CRC) is one common type of gastrointestinal malignancy. The incidence of CRC appears to have an upward trend year by year since the enhancement of living standards. Although surgery and chemoradiotherapy have largely improved the prognosis of patients with CRC, some patients still appear to have severe adverse reactions and drug resistance. Moreover, much research has verified that ferroptosis has a necessary association with the occurrence and progression of gastrointestinal tumors. In this review, we provide a comprehensive evaluation of the main mechanisms of iron metabolism, lipid metabolism, and amino acid metabolism involved in the occurrence of ferroptosis, as well as the research progress of ferroptosis in CRC. |
| first_indexed | 2024-03-09T12:58:08Z |
| format | Article |
| id | doaj.art-b2d6561c55ca4c6e91423bd3bcf2a319 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T12:58:08Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-b2d6561c55ca4c6e91423bd3bcf2a3192023-11-30T21:58:24ZengMDPI AGMetabolites2218-19892022-08-0112874510.3390/metabo12080745Targeting Ferroptosis in Colorectal CancerXiaojie Liang0Zhihuan You1Xinhao Chen2Jun Li3Department of General Surgery, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, ChinaDepartment of Cardiology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, ChinaDepartment of General Surgery, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, ChinaFerroptosis is a unique way of regulating cell death (RCD), which is quite different from other programmed cell deaths such as autophagy. It presents iron overload, accumulation of reactive oxygen species (ROS), and lipid peroxidation. A ferroptotic cell usually has an intact cell structure as well as shrinking mitochondria with decreased or vanishing cristae, concentrated membrane density, and ruptured outer membrane. Recently, increasing investigations have discovered that tumor cells have a much greater iron demand than the normal ones, making them more sensitive to ferroptosis. In other words, ferroptosis may inhibit the progress of the tumor, which can be used in the therapy of tumor patients, especially for those with chemotherapy resistance. Therefore, ferroptosis has become one hot spot in the field of tumor research in recent years. Colorectal cancer (CRC) is one common type of gastrointestinal malignancy. The incidence of CRC appears to have an upward trend year by year since the enhancement of living standards. Although surgery and chemoradiotherapy have largely improved the prognosis of patients with CRC, some patients still appear to have severe adverse reactions and drug resistance. Moreover, much research has verified that ferroptosis has a necessary association with the occurrence and progression of gastrointestinal tumors. In this review, we provide a comprehensive evaluation of the main mechanisms of iron metabolism, lipid metabolism, and amino acid metabolism involved in the occurrence of ferroptosis, as well as the research progress of ferroptosis in CRC.https://www.mdpi.com/2218-1989/12/8/745ferroptosis 1colorectal cancer 2iron ions 3lipid peroxides 4 |
| spellingShingle | Xiaojie Liang Zhihuan You Xinhao Chen Jun Li Targeting Ferroptosis in Colorectal Cancer Metabolites ferroptosis 1 colorectal cancer 2 iron ions 3 lipid peroxides 4 |
| title | Targeting Ferroptosis in Colorectal Cancer |
| title_full | Targeting Ferroptosis in Colorectal Cancer |
| title_fullStr | Targeting Ferroptosis in Colorectal Cancer |
| title_full_unstemmed | Targeting Ferroptosis in Colorectal Cancer |
| title_short | Targeting Ferroptosis in Colorectal Cancer |
| title_sort | targeting ferroptosis in colorectal cancer |
| topic | ferroptosis 1 colorectal cancer 2 iron ions 3 lipid peroxides 4 |
| url | https://www.mdpi.com/2218-1989/12/8/745 |
| work_keys_str_mv | AT xiaojieliang targetingferroptosisincolorectalcancer AT zhihuanyou targetingferroptosisincolorectalcancer AT xinhaochen targetingferroptosisincolorectalcancer AT junli targetingferroptosisincolorectalcancer |