Red Upconverter Nanocrystals Functionalized with Verteporfin for Photodynamic Therapy Triggered by Upconversion
Upconversion (UC) nanoparticles characterized by red upconversion emission, particularly interesting for biological applications, have been prepared and subsequently modified by the covalent anchoring of Verteporfin (Ver), an FDA approved photosensitizer (PS) which usually exerts its photodynamic ac...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/13/6951 |
| _version_ | 1797479877675319296 |
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| author | Ivana Miletto Chiara Gionco Maria Cristina Paganini Erik Cerrato Leonardo Marchese Enrica Gianotti |
| author_facet | Ivana Miletto Chiara Gionco Maria Cristina Paganini Erik Cerrato Leonardo Marchese Enrica Gianotti |
| author_sort | Ivana Miletto |
| collection | DOAJ |
| description | Upconversion (UC) nanoparticles characterized by red upconversion emission, particularly interesting for biological applications, have been prepared and subsequently modified by the covalent anchoring of Verteporfin (Ver), an FDA approved photosensitizer (PS) which usually exerts its photodynamic activity upon excitation with red light. ZrO<sub>2</sub> was chosen as the platform where Yb<sup>3+</sup> and Er<sup>3+</sup> were inserted as the sensitizer and activator ions, respectively. Careful control of the doping ratio, along with a detailed physico-chemical characterization, was carried out. Upon functionalization with a silica shell to covalently anchor the photosensitizer, a theranostic nanoparticle was obtained whose architecture, thanks to a favorable energy level match and a uniform distribution of the PS, allowed us to trigger the photodynamic activity of Ver by upconversion, thus paving the way to the use of Photodynamic Therapy (PDT) in deep tissues, thanks to the higher penetrating power of NIR light. |
| first_indexed | 2024-03-09T21:52:07Z |
| format | Article |
| id | doaj.art-b2d858614c144280a382f355b5a909e3 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:52:07Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b2d858614c144280a382f355b5a909e32023-11-23T20:05:22ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012313695110.3390/ijms23136951Red Upconverter Nanocrystals Functionalized with Verteporfin for Photodynamic Therapy Triggered by UpconversionIvana Miletto0Chiara Gionco1Maria Cristina Paganini2Erik Cerrato3Leonardo Marchese4Enrica Gianotti5Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Largo Donegani 2/3, 28100 Novara, ItalyDipartimento di Chimica, Università degli Studi di Torino, Via Pietro Giuria 9, 10125 Torino, ItalyDipartimento di Chimica, Università degli Studi di Torino, Via Pietro Giuria 9, 10125 Torino, ItalyDipartimento di Chimica, Università degli Studi di Torino, Via Pietro Giuria 9, 10125 Torino, ItalyDipartimento di Scienze ed Innovazione Tecnologica, Università del Piemonte Orientale, Viale Teresa Michel 11, 15121 Alessandria, ItalyDipartimento per la Sostenibilità e la Transizione Ecologica, Università del Piemonte Orientale, Piazza Sant’Eusebio 5, 13100 Vercelli, ItalyUpconversion (UC) nanoparticles characterized by red upconversion emission, particularly interesting for biological applications, have been prepared and subsequently modified by the covalent anchoring of Verteporfin (Ver), an FDA approved photosensitizer (PS) which usually exerts its photodynamic activity upon excitation with red light. ZrO<sub>2</sub> was chosen as the platform where Yb<sup>3+</sup> and Er<sup>3+</sup> were inserted as the sensitizer and activator ions, respectively. Careful control of the doping ratio, along with a detailed physico-chemical characterization, was carried out. Upon functionalization with a silica shell to covalently anchor the photosensitizer, a theranostic nanoparticle was obtained whose architecture, thanks to a favorable energy level match and a uniform distribution of the PS, allowed us to trigger the photodynamic activity of Ver by upconversion, thus paving the way to the use of Photodynamic Therapy (PDT) in deep tissues, thanks to the higher penetrating power of NIR light.https://www.mdpi.com/1422-0067/23/13/6951red upconverter nanoparticlesupconversionphotodynamic therapytheranosticoptical imagingcore–shell nanoparticles |
| spellingShingle | Ivana Miletto Chiara Gionco Maria Cristina Paganini Erik Cerrato Leonardo Marchese Enrica Gianotti Red Upconverter Nanocrystals Functionalized with Verteporfin for Photodynamic Therapy Triggered by Upconversion International Journal of Molecular Sciences red upconverter nanoparticles upconversion photodynamic therapy theranostic optical imaging core–shell nanoparticles |
| title | Red Upconverter Nanocrystals Functionalized with Verteporfin for Photodynamic Therapy Triggered by Upconversion |
| title_full | Red Upconverter Nanocrystals Functionalized with Verteporfin for Photodynamic Therapy Triggered by Upconversion |
| title_fullStr | Red Upconverter Nanocrystals Functionalized with Verteporfin for Photodynamic Therapy Triggered by Upconversion |
| title_full_unstemmed | Red Upconverter Nanocrystals Functionalized with Verteporfin for Photodynamic Therapy Triggered by Upconversion |
| title_short | Red Upconverter Nanocrystals Functionalized with Verteporfin for Photodynamic Therapy Triggered by Upconversion |
| title_sort | red upconverter nanocrystals functionalized with verteporfin for photodynamic therapy triggered by upconversion |
| topic | red upconverter nanoparticles upconversion photodynamic therapy theranostic optical imaging core–shell nanoparticles |
| url | https://www.mdpi.com/1422-0067/23/13/6951 |
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