Monitoring of post-vaccination anti-HBs titles vaccine in children and adolescents in the pre-dialysis of chronic kidney disease
Abstract Introduction: Bacterial or viral diseases are one of the major causes of death in patients with chronic kidney disease (CKD). These patients show a quantitative reduction of levels of antibodies over time. Among the infectious diseases that affect CKD patients, stands out hepatitis B (HB)....
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Nefrologia
2017-08-01
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| Series: | Brazilian Journal of Nephrology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017001303105&lng=en&tlng=en |
| _version_ | 1818145429784625152 |
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| author | Nathália Cristina Pereira da Costa Mônica Ribeiro Canhestro Cristina Maria Bouissou Morais Soares Juliana Scudilio Rodrigues |
| author_facet | Nathália Cristina Pereira da Costa Mônica Ribeiro Canhestro Cristina Maria Bouissou Morais Soares Juliana Scudilio Rodrigues |
| author_sort | Nathália Cristina Pereira da Costa |
| collection | DOAJ |
| description | Abstract Introduction: Bacterial or viral diseases are one of the major causes of death in patients with chronic kidney disease (CKD). These patients show a quantitative reduction of levels of antibodies over time. Among the infectious diseases that affect CKD patients, stands out hepatitis B (HB). Immunization and control of antibodies levels against the hepatitis B surface antigen (anti-HBs) are ways to prevent the HB infection in this population. Patients with anti-HBs levels ≥10 IU/ml are considered adequate responders, whereas those with anti-HBs levels ≥ 100 IU/ml are considered excellent responders. Objective: To analyze the variation of the anti-HBs levels obtained after vaccination against HB in children and adolescents in the pre-dialysis stage of CKD. Methods: A retrospective cohort study on anti-HBs levels of children and adolescents in the pre-dialysis stage of CKD. Correlation between levels of anti-HBs titers and time since the vaccination were estimated. Results: From the total of 116 studied patients most of the studied patients were considered excellent responders, obtaining in the three anti-HBs titers percentages of 70.7%, 62.1% and 54.9% respectively. The anti-HBs titer levels showed a negative correlation with the time since vaccination (Kendall Tau-b = -0.16; p = 0.02). Conclusion: The majority of the studied population was vaccinated by PNI and showed excellent anti-HBs titer levels, even experiencing a progressive reduced response over the time. |
| first_indexed | 2024-12-11T12:03:19Z |
| format | Article |
| id | doaj.art-b2d8f0438c7b4aa0a585567c71725e5d |
| institution | Directory Open Access Journal |
| issn | 2175-8239 |
| language | English |
| last_indexed | 2024-12-11T12:03:19Z |
| publishDate | 2017-08-01 |
| publisher | Sociedade Brasileira de Nefrologia |
| record_format | Article |
| series | Brazilian Journal of Nephrology |
| spelling | doaj.art-b2d8f0438c7b4aa0a585567c71725e5d2022-12-22T01:08:00ZengSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology2175-82392017-08-01010.5935/0101-2800.20170044S0101-28002017001303105Monitoring of post-vaccination anti-HBs titles vaccine in children and adolescents in the pre-dialysis of chronic kidney diseaseNathália Cristina Pereira da CostaMônica Ribeiro CanhestroCristina Maria Bouissou Morais SoaresJuliana Scudilio RodriguesAbstract Introduction: Bacterial or viral diseases are one of the major causes of death in patients with chronic kidney disease (CKD). These patients show a quantitative reduction of levels of antibodies over time. Among the infectious diseases that affect CKD patients, stands out hepatitis B (HB). Immunization and control of antibodies levels against the hepatitis B surface antigen (anti-HBs) are ways to prevent the HB infection in this population. Patients with anti-HBs levels ≥10 IU/ml are considered adequate responders, whereas those with anti-HBs levels ≥ 100 IU/ml are considered excellent responders. Objective: To analyze the variation of the anti-HBs levels obtained after vaccination against HB in children and adolescents in the pre-dialysis stage of CKD. Methods: A retrospective cohort study on anti-HBs levels of children and adolescents in the pre-dialysis stage of CKD. Correlation between levels of anti-HBs titers and time since the vaccination were estimated. Results: From the total of 116 studied patients most of the studied patients were considered excellent responders, obtaining in the three anti-HBs titers percentages of 70.7%, 62.1% and 54.9% respectively. The anti-HBs titer levels showed a negative correlation with the time since vaccination (Kendall Tau-b = -0.16; p = 0.02). Conclusion: The majority of the studied population was vaccinated by PNI and showed excellent anti-HBs titer levels, even experiencing a progressive reduced response over the time.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017001303105&lng=en&tlng=enrenal insufficiency, chronichepatitis Bimmunizationpediatrics |
| spellingShingle | Nathália Cristina Pereira da Costa Mônica Ribeiro Canhestro Cristina Maria Bouissou Morais Soares Juliana Scudilio Rodrigues Monitoring of post-vaccination anti-HBs titles vaccine in children and adolescents in the pre-dialysis of chronic kidney disease Brazilian Journal of Nephrology renal insufficiency, chronic hepatitis B immunization pediatrics |
| title | Monitoring of post-vaccination anti-HBs titles vaccine in children and adolescents in the pre-dialysis of chronic kidney disease |
| title_full | Monitoring of post-vaccination anti-HBs titles vaccine in children and adolescents in the pre-dialysis of chronic kidney disease |
| title_fullStr | Monitoring of post-vaccination anti-HBs titles vaccine in children and adolescents in the pre-dialysis of chronic kidney disease |
| title_full_unstemmed | Monitoring of post-vaccination anti-HBs titles vaccine in children and adolescents in the pre-dialysis of chronic kidney disease |
| title_short | Monitoring of post-vaccination anti-HBs titles vaccine in children and adolescents in the pre-dialysis of chronic kidney disease |
| title_sort | monitoring of post vaccination anti hbs titles vaccine in children and adolescents in the pre dialysis of chronic kidney disease |
| topic | renal insufficiency, chronic hepatitis B immunization pediatrics |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017001303105&lng=en&tlng=en |
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