Problems of diagnosing focal cortical dysplasia
Focal cortical dysplasia (FCD) is one of the most common causes in developing pharmacoresistant epilepsy. We present the clinical case of the patient with generalized seizures. Routine electroencephalography (EEG) data registered diffuse epileptiform activity that allowed to diagnose genetic eneral...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2021-04-01
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| Series: | Эпилепсия и пароксизмальные состояния |
| Subjects: | |
| Online Access: | https://www.epilepsia.su/jour/article/view/654 |
| _version_ | 1797879401321332736 |
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| author | K. D. Yakovleva E. A. Kantemirova D. V. Dmitrenko |
| author_facet | K. D. Yakovleva E. A. Kantemirova D. V. Dmitrenko |
| author_sort | K. D. Yakovleva |
| collection | DOAJ |
| description | Focal cortical dysplasia (FCD) is one of the most common causes in developing pharmacoresistant epilepsy. We present the clinical case of the patient with generalized seizures. Routine electroencephalography (EEG) data registered diffuse epileptiform activity that allowed to diagnose genetic eneralized epilepsy and pharmacoresistant course of seizures.After performing magnetic resonance imaging using the epileptological program and video-EEG-monitoring, the diagnosis was revised: structural focal epilepsy with seizures with focal onset with oroalimentary, gesture automatisms in the right hand, bilateral tonic-clonic, uncompensated by levetiracetam monotherapy (1500 mg/day). Background disease: congenital malformation of the brain: FCD in the basal parts of the left temporal lobe. Lacosamide was added to the therapy in the drug dose 300 mg/day, and the frequency of epileptic seizures decreased. Differential diagnosis between genetic generalized epilepsy and structural epilepsy with FCD usually poses no obstacles. However, in some cases, structural epilepsy occurs under the “mask” of generalized epilepsy. Hence, this clinical case demonstrates the importance of diagnostic measures in the differential diagnostics of various forms of epilepsy to determine further tactics of patient management. |
| first_indexed | 2024-04-10T02:47:02Z |
| format | Article |
| id | doaj.art-b2d9f49a6b3441fb9dde735e9b8b5a89 |
| institution | Directory Open Access Journal |
| issn | 2077-8333 2311-4088 |
| language | Russian |
| last_indexed | 2024-04-10T02:47:02Z |
| publishDate | 2021-04-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Эпилепсия и пароксизмальные состояния |
| spelling | doaj.art-b2d9f49a6b3441fb9dde735e9b8b5a892023-03-13T07:44:17ZrusIRBIS LLCЭпилепсия и пароксизмальные состояния2077-83332311-40882021-04-01131334310.17749/2077-8333/epi.par.con.2021.047512Problems of diagnosing focal cortical dysplasiaK. D. Yakovleva0E. A. Kantemirova1D. V. Dmitrenko2Voyno-Yasenetskiy Krasnoyarsk State Medical UniversityVoyno-Yasenetskiy Krasnoyarsk State Medical UniversityVoyno-Yasenetskiy Krasnoyarsk State Medical UniversityFocal cortical dysplasia (FCD) is one of the most common causes in developing pharmacoresistant epilepsy. We present the clinical case of the patient with generalized seizures. Routine electroencephalography (EEG) data registered diffuse epileptiform activity that allowed to diagnose genetic eneralized epilepsy and pharmacoresistant course of seizures.After performing magnetic resonance imaging using the epileptological program and video-EEG-monitoring, the diagnosis was revised: structural focal epilepsy with seizures with focal onset with oroalimentary, gesture automatisms in the right hand, bilateral tonic-clonic, uncompensated by levetiracetam monotherapy (1500 mg/day). Background disease: congenital malformation of the brain: FCD in the basal parts of the left temporal lobe. Lacosamide was added to the therapy in the drug dose 300 mg/day, and the frequency of epileptic seizures decreased. Differential diagnosis between genetic generalized epilepsy and structural epilepsy with FCD usually poses no obstacles. However, in some cases, structural epilepsy occurs under the “mask” of generalized epilepsy. Hence, this clinical case demonstrates the importance of diagnostic measures in the differential diagnostics of various forms of epilepsy to determine further tactics of patient management.https://www.epilepsia.su/jour/article/view/654focal cortical dysplasiamagnetic resonance imagingvideo-eeg monitoringgeneralized seizuresgeneralized epileptiform activity |
| spellingShingle | K. D. Yakovleva E. A. Kantemirova D. V. Dmitrenko Problems of diagnosing focal cortical dysplasia Эпилепсия и пароксизмальные состояния focal cortical dysplasia magnetic resonance imaging video-eeg monitoring generalized seizures generalized epileptiform activity |
| title | Problems of diagnosing focal cortical dysplasia |
| title_full | Problems of diagnosing focal cortical dysplasia |
| title_fullStr | Problems of diagnosing focal cortical dysplasia |
| title_full_unstemmed | Problems of diagnosing focal cortical dysplasia |
| title_short | Problems of diagnosing focal cortical dysplasia |
| title_sort | problems of diagnosing focal cortical dysplasia |
| topic | focal cortical dysplasia magnetic resonance imaging video-eeg monitoring generalized seizures generalized epileptiform activity |
| url | https://www.epilepsia.su/jour/article/view/654 |
| work_keys_str_mv | AT kdyakovleva problemsofdiagnosingfocalcorticaldysplasia AT eakantemirova problemsofdiagnosingfocalcorticaldysplasia AT dvdmitrenko problemsofdiagnosingfocalcorticaldysplasia |