Clinicopathological characteristics and prognosis of brain metastases in elderly patients with esophageal carcinoma
Abstract Background Brain metastases (BM) from esophageal carcinoma (EC) is clinically rare and has not yet been reported in elderly patients. This study aimed to investigate the clinicopathological characteristics, outcomes and prognostic factors of BM in elderly patients with EC, in order to provi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-11-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.14167 |
| _version_ | 1798033190339739648 |
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| author | Yi Wang Linlin Xiao Jiandong Zhang Xiaoyan Lv Feng Cao Min Zhao Fengpeng Wu Shaowu Jing Jun Wang |
| author_facet | Yi Wang Linlin Xiao Jiandong Zhang Xiaoyan Lv Feng Cao Min Zhao Fengpeng Wu Shaowu Jing Jun Wang |
| author_sort | Yi Wang |
| collection | DOAJ |
| description | Abstract Background Brain metastases (BM) from esophageal carcinoma (EC) is clinically rare and has not yet been reported in elderly patients. This study aimed to investigate the clinicopathological characteristics, outcomes and prognostic factors of BM in elderly patients with EC, in order to provide guidance for clinical practice. Methods A total of 20 EC patients older than 65 years who were diagnosed with BM were identified from the fourth Hospital of Hebei Medical University between January 1, 2009 and December 31, 2018. Survival was evaluated by the Kaplan–Meier method and Cox proportional hazards models. Results The median time from diagnosis of EC to BM was 11.8 months (0–249.2 months). The median overall survival (OS) was 4.8 months (1.13–23.3 months), with 20% of patients achieving the 1‐year survival rate. Patients with KPS score of ≥70 had a significantly better OS than those with KPS score<70 (8.4 vs. 3.9 months, p = 0.033). Compared to patients without brain radiotherapy, patients with brain radiotherapy showed better outcomes in both median OS (8.4 vs. 2.9 months) and 1‐year survival rate (23.1% vs. 14.3%, p = 0.043). The median OS of patients with radiotherapy combined with chemotherapy and/or targeted therapy and radiotherapy alone was 9.7 months (3.4–23.3 months) and 7.2 months (1.7–18.4 months), respectively, with no significant difference between the two groups (p = 0.215). Conclusions Brain radiotherapy provided clinically meaningful survival benefit for elderly patients with BM from EC. Thus, active treatments for those patients might be required. |
| first_indexed | 2024-04-11T20:26:20Z |
| format | Article |
| id | doaj.art-b2da3f3c8f8c4bbbb5dc85324e9c29fe |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-11T20:26:20Z |
| publishDate | 2021-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-b2da3f3c8f8c4bbbb5dc85324e9c29fe2022-12-22T04:04:40ZengWileyThoracic Cancer1759-77061759-77142021-11-0112223005301010.1111/1759-7714.14167Clinicopathological characteristics and prognosis of brain metastases in elderly patients with esophageal carcinomaYi Wang0Linlin Xiao1Jiandong Zhang2Xiaoyan Lv3Feng Cao4Min Zhao5Fengpeng Wu6Shaowu Jing7Jun Wang8Department of Radiation Oncology Fourth Hospital of Hebei Medical University Shijiazhuang ChinaDepartment of Radiation Oncology Fourth Hospital of Hebei Medical University Shijiazhuang ChinaDepartment of Radiation Oncology The First Affiliated Hospital of Shandong First Medical University Jinan ChinaDepartment of Radiation Oncology Fourth Hospital of Hebei Medical University Shijiazhuang ChinaDepartment of Radiation Oncology Fourth Hospital of Hebei Medical University Shijiazhuang ChinaDepartment of Oncology, Hebei Chest Hospital Research Center of Hebei Lung Cancer Prevention and Treatment Shijiazhuang ChinaDepartment of Radiation Oncology Fourth Hospital of Hebei Medical University Shijiazhuang ChinaDepartment of Radiation Oncology Fourth Hospital of Hebei Medical University Shijiazhuang ChinaDepartment of Radiation Oncology Fourth Hospital of Hebei Medical University Shijiazhuang ChinaAbstract Background Brain metastases (BM) from esophageal carcinoma (EC) is clinically rare and has not yet been reported in elderly patients. This study aimed to investigate the clinicopathological characteristics, outcomes and prognostic factors of BM in elderly patients with EC, in order to provide guidance for clinical practice. Methods A total of 20 EC patients older than 65 years who were diagnosed with BM were identified from the fourth Hospital of Hebei Medical University between January 1, 2009 and December 31, 2018. Survival was evaluated by the Kaplan–Meier method and Cox proportional hazards models. Results The median time from diagnosis of EC to BM was 11.8 months (0–249.2 months). The median overall survival (OS) was 4.8 months (1.13–23.3 months), with 20% of patients achieving the 1‐year survival rate. Patients with KPS score of ≥70 had a significantly better OS than those with KPS score<70 (8.4 vs. 3.9 months, p = 0.033). Compared to patients without brain radiotherapy, patients with brain radiotherapy showed better outcomes in both median OS (8.4 vs. 2.9 months) and 1‐year survival rate (23.1% vs. 14.3%, p = 0.043). The median OS of patients with radiotherapy combined with chemotherapy and/or targeted therapy and radiotherapy alone was 9.7 months (3.4–23.3 months) and 7.2 months (1.7–18.4 months), respectively, with no significant difference between the two groups (p = 0.215). Conclusions Brain radiotherapy provided clinically meaningful survival benefit for elderly patients with BM from EC. Thus, active treatments for those patients might be required.https://doi.org/10.1111/1759-7714.14167brain metastaseselderly patientsesophageal carcinomaprognosisradiotherapy |
| spellingShingle | Yi Wang Linlin Xiao Jiandong Zhang Xiaoyan Lv Feng Cao Min Zhao Fengpeng Wu Shaowu Jing Jun Wang Clinicopathological characteristics and prognosis of brain metastases in elderly patients with esophageal carcinoma Thoracic Cancer brain metastases elderly patients esophageal carcinoma prognosis radiotherapy |
| title | Clinicopathological characteristics and prognosis of brain metastases in elderly patients with esophageal carcinoma |
| title_full | Clinicopathological characteristics and prognosis of brain metastases in elderly patients with esophageal carcinoma |
| title_fullStr | Clinicopathological characteristics and prognosis of brain metastases in elderly patients with esophageal carcinoma |
| title_full_unstemmed | Clinicopathological characteristics and prognosis of brain metastases in elderly patients with esophageal carcinoma |
| title_short | Clinicopathological characteristics and prognosis of brain metastases in elderly patients with esophageal carcinoma |
| title_sort | clinicopathological characteristics and prognosis of brain metastases in elderly patients with esophageal carcinoma |
| topic | brain metastases elderly patients esophageal carcinoma prognosis radiotherapy |
| url | https://doi.org/10.1111/1759-7714.14167 |
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