Diabetic sensory neuropathy and insulin resistance are induced by loss of UCHL1 in Drosophila
Abstract Diabetic sensory neuropathy (DSN) is one of the most common complications of type 2 diabetes (T2D), however the molecular mechanistic association between T2D and DSN remains elusive. Here we identify ubiquitin C-terminal hydrolase L1 (UCHL1), a deubiquitinase highly expressed in neurons, as...
Main Authors: | Daewon Lee, Eunju Yoon, Su Jin Ham, Kunwoo Lee, Hansaem Jang, Daihn Woo, Da Hyun Lee, Sehyeon Kim, Sekyu Choi, Jongkyeong Chung |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2024-01-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-024-44747-9 |
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