Effect of Ondansetron on Prevention of Ventilator Associated Pneumonia in Intensive Care Unit Patients in Kashani Hospital in 2013
Introduction: Ventilator Associated Pneumonia (VAP) is the second most common infection with high mortality (24-50%). Ondansetron is a reliable and safe drug and it is currently used in the prevention of nausea and vomiting and has no side effects. Aim: The aim of the present study was to examin...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2017-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/10424/25859_CE[EK]_F(2)SS_PF1(EK_OM)_PF2(AK_EK_OM).pdf |
| _version_ | 1818127895705419776 |
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| author | Hossein Madineh Omolbanin Rahimi MohamadReza Abedin Zadeh Majid Kabiri |
| author_facet | Hossein Madineh Omolbanin Rahimi MohamadReza Abedin Zadeh Majid Kabiri |
| author_sort | Hossein Madineh |
| collection | DOAJ |
| description | Introduction: Ventilator Associated Pneumonia (VAP) is the
second most common infection with high mortality (24-50%).
Ondansetron is a reliable and safe drug and it is currently used in
the prevention of nausea and vomiting and has no side effects.
Aim: The aim of the present study was to examine the effect of
ondansetron on prevention of VAP in Intensive Care Unit (ICU)
patients.
Materials and Methods: The present study was a randomized
clinical trial study (IRCT201406156480N6), carried out at Kashani
Hospital, Iran, in 2013 on 80 patients aged from 15-65 years.
The patients were randomly allocated to two groups: Case group
(n=40) and Control group (n=40). The patients in first group were
injected with 4 mg ondansetron, twice daily for five days. The
patients of other group were injected with distilled water as
placebo. The presence of VAP was assessed in the two groups.
The collected data were analysed by SPSS software through
Fisher-exact test.
Results: Eleven (13.8%) patients were diagnosed with VAP.
Among them, 9 (81.8%) patients were male and 2 (18.2%) patients
were female. The incidence of VAP in Case group was 5 (12.5%)
patients and in Control group was 6 (15%) patients (p>0.05).
Results showed that VAP in Case group was less prevalent than
that in the Control group, but this difference was not significant.
Conclusion: The study did not find an association between
ondansetron administration and reduction in VAP incidence;
vomiting alone may not be leading to VAP, instead silent micro
aspirations may be the cause of it. None of the factor such as
age, sex, weight, smoking, drug addiction was found significantly
related to VAP. Only variable found related was comorbidity. |
| first_indexed | 2024-12-11T07:24:38Z |
| format | Article |
| id | doaj.art-b2dde4641259481f8d07e0ad811e80ea |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-11T07:24:38Z |
| publishDate | 2017-08-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-b2dde4641259481f8d07e0ad811e80ea2022-12-22T01:16:00ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-08-01118UC05UC0810.7860/JCDR/2017/25859.10424Effect of Ondansetron on Prevention of Ventilator Associated Pneumonia in Intensive Care Unit Patients in Kashani Hospital in 2013Hossein Madineh0Omolbanin Rahimi1MohamadReza Abedin Zadeh2Majid Kabiri3Assistant Professor, Department of Anesthesiology, Shahrekord University of Medical Sciences, Kashani Hospital, Shahrekord, Iran.Assistant Professor, Department of Anesthesiology, Kashani Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran.Assistant Professor, Department of Anesthesiology, Kashani Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran.Assistant Professor, Department of Anesthesiology, Kashani Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran.Introduction: Ventilator Associated Pneumonia (VAP) is the second most common infection with high mortality (24-50%). Ondansetron is a reliable and safe drug and it is currently used in the prevention of nausea and vomiting and has no side effects. Aim: The aim of the present study was to examine the effect of ondansetron on prevention of VAP in Intensive Care Unit (ICU) patients. Materials and Methods: The present study was a randomized clinical trial study (IRCT201406156480N6), carried out at Kashani Hospital, Iran, in 2013 on 80 patients aged from 15-65 years. The patients were randomly allocated to two groups: Case group (n=40) and Control group (n=40). The patients in first group were injected with 4 mg ondansetron, twice daily for five days. The patients of other group were injected with distilled water as placebo. The presence of VAP was assessed in the two groups. The collected data were analysed by SPSS software through Fisher-exact test. Results: Eleven (13.8%) patients were diagnosed with VAP. Among them, 9 (81.8%) patients were male and 2 (18.2%) patients were female. The incidence of VAP in Case group was 5 (12.5%) patients and in Control group was 6 (15%) patients (p>0.05). Results showed that VAP in Case group was less prevalent than that in the Control group, but this difference was not significant. Conclusion: The study did not find an association between ondansetron administration and reduction in VAP incidence; vomiting alone may not be leading to VAP, instead silent micro aspirations may be the cause of it. None of the factor such as age, sex, weight, smoking, drug addiction was found significantly related to VAP. Only variable found related was comorbidity.https://jcdr.net/articles/PDF/10424/25859_CE[EK]_F(2)SS_PF1(EK_OM)_PF2(AK_EK_OM).pdfinflammation of the lungnosocomial infectionspulmonary diseasesrespiratory tract diseases |
| spellingShingle | Hossein Madineh Omolbanin Rahimi MohamadReza Abedin Zadeh Majid Kabiri Effect of Ondansetron on Prevention of Ventilator Associated Pneumonia in Intensive Care Unit Patients in Kashani Hospital in 2013 Journal of Clinical and Diagnostic Research inflammation of the lung nosocomial infections pulmonary diseases respiratory tract diseases |
| title | Effect of Ondansetron on Prevention of Ventilator Associated Pneumonia in Intensive Care Unit Patients in Kashani Hospital in 2013 |
| title_full | Effect of Ondansetron on Prevention of Ventilator Associated Pneumonia in Intensive Care Unit Patients in Kashani Hospital in 2013 |
| title_fullStr | Effect of Ondansetron on Prevention of Ventilator Associated Pneumonia in Intensive Care Unit Patients in Kashani Hospital in 2013 |
| title_full_unstemmed | Effect of Ondansetron on Prevention of Ventilator Associated Pneumonia in Intensive Care Unit Patients in Kashani Hospital in 2013 |
| title_short | Effect of Ondansetron on Prevention of Ventilator Associated Pneumonia in Intensive Care Unit Patients in Kashani Hospital in 2013 |
| title_sort | effect of ondansetron on prevention of ventilator associated pneumonia in intensive care unit patients in kashani hospital in 2013 |
| topic | inflammation of the lung nosocomial infections pulmonary diseases respiratory tract diseases |
| url | https://jcdr.net/articles/PDF/10424/25859_CE[EK]_F(2)SS_PF1(EK_OM)_PF2(AK_EK_OM).pdf |
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