Roles of Histone Acetylation Modifiers and Other Epigenetic Regulators in Vascular Calcification
Vascular calcification (VC) is characterized by calcium deposition inside arteries and is closely associated with the morbidity and mortality of atherosclerosis, chronic kidney disease, diabetes, and other cardiovascular diseases (CVDs). VC is now widely known to be an active process occurring in va...
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| Format: | Article |
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MDPI AG
2020-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/9/3246 |
| _version_ | 1797568829703847936 |
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| author | Duk-Hwa Kwon Juhee Ryu Young-Kook Kim Hyun Kook |
| author_facet | Duk-Hwa Kwon Juhee Ryu Young-Kook Kim Hyun Kook |
| author_sort | Duk-Hwa Kwon |
| collection | DOAJ |
| description | Vascular calcification (VC) is characterized by calcium deposition inside arteries and is closely associated with the morbidity and mortality of atherosclerosis, chronic kidney disease, diabetes, and other cardiovascular diseases (CVDs). VC is now widely known to be an active process occurring in vascular smooth muscle cells (VSMCs) involving multiple mechanisms and factors. These mechanisms share features with the process of bone formation, since the phenotype switching from the contractile to the osteochondrogenic phenotype also occurs in VSMCs during VC. In addition, VC can be regulated by epigenetic factors, including DNA methylation, histone modification, and noncoding RNAs. Although VC is commonly observed in patients with chronic kidney disease and CVD, specific drugs for VC have not been developed. Thus, discovering novel therapeutic targets may be necessary. In this review, we summarize the current experimental evidence regarding the role of epigenetic regulators including histone deacetylases and propose the therapeutic implication of these regulators in the treatment of VC. |
| first_indexed | 2024-03-10T20:02:38Z |
| format | Article |
| id | doaj.art-b2dfb48e14144d7da853417c6232cebd |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:02:38Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b2dfb48e14144d7da853417c6232cebd2023-11-19T23:27:07ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-01219324610.3390/ijms21093246Roles of Histone Acetylation Modifiers and Other Epigenetic Regulators in Vascular CalcificationDuk-Hwa Kwon0Juhee Ryu1Young-Kook Kim2Hyun Kook3Department of Pharmacology, Chonnam National University Medical School, Hwasun 58128, KoreaDepartment of Pharmacology, Chonnam National University Medical School, Hwasun 58128, KoreaDepartment of Biochemistry, Chonnam National University Medical School, Hwasun 58128, KoreaDepartment of Pharmacology, Chonnam National University Medical School, Hwasun 58128, KoreaVascular calcification (VC) is characterized by calcium deposition inside arteries and is closely associated with the morbidity and mortality of atherosclerosis, chronic kidney disease, diabetes, and other cardiovascular diseases (CVDs). VC is now widely known to be an active process occurring in vascular smooth muscle cells (VSMCs) involving multiple mechanisms and factors. These mechanisms share features with the process of bone formation, since the phenotype switching from the contractile to the osteochondrogenic phenotype also occurs in VSMCs during VC. In addition, VC can be regulated by epigenetic factors, including DNA methylation, histone modification, and noncoding RNAs. Although VC is commonly observed in patients with chronic kidney disease and CVD, specific drugs for VC have not been developed. Thus, discovering novel therapeutic targets may be necessary. In this review, we summarize the current experimental evidence regarding the role of epigenetic regulators including histone deacetylases and propose the therapeutic implication of these regulators in the treatment of VC.https://www.mdpi.com/1422-0067/21/9/3246histone deacetylasehistone modifiersepigenetic regulatorvascular calcificationvascular smooth muscle cellspost-translational modification |
| spellingShingle | Duk-Hwa Kwon Juhee Ryu Young-Kook Kim Hyun Kook Roles of Histone Acetylation Modifiers and Other Epigenetic Regulators in Vascular Calcification International Journal of Molecular Sciences histone deacetylase histone modifiers epigenetic regulator vascular calcification vascular smooth muscle cells post-translational modification |
| title | Roles of Histone Acetylation Modifiers and Other Epigenetic Regulators in Vascular Calcification |
| title_full | Roles of Histone Acetylation Modifiers and Other Epigenetic Regulators in Vascular Calcification |
| title_fullStr | Roles of Histone Acetylation Modifiers and Other Epigenetic Regulators in Vascular Calcification |
| title_full_unstemmed | Roles of Histone Acetylation Modifiers and Other Epigenetic Regulators in Vascular Calcification |
| title_short | Roles of Histone Acetylation Modifiers and Other Epigenetic Regulators in Vascular Calcification |
| title_sort | roles of histone acetylation modifiers and other epigenetic regulators in vascular calcification |
| topic | histone deacetylase histone modifiers epigenetic regulator vascular calcification vascular smooth muscle cells post-translational modification |
| url | https://www.mdpi.com/1422-0067/21/9/3246 |
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