Coronary functional assessment in non-obstructive coronary artery disease: Present situation and future direction
Non-obstructive coronary artery disease (CAD), which is defined as coronary stenosis <50%, has been increasingly recognized as an emerging entity in clinical practice. Vasomotion abnormality and coronary microvascular dysfunction are two major mechanisms contributing to the occur of angina wi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.934279/full |
| _version_ | 1811339631515402240 |
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| author | Changlin Zhai Hongyan Fan Yujuan Zhu Yunqing Chen Liang Shen |
| author_facet | Changlin Zhai Hongyan Fan Yujuan Zhu Yunqing Chen Liang Shen |
| author_sort | Changlin Zhai |
| collection | DOAJ |
| description | Non-obstructive coronary artery disease (CAD), which is defined as coronary stenosis <50%, has been increasingly recognized as an emerging entity in clinical practice. Vasomotion abnormality and coronary microvascular dysfunction are two major mechanisms contributing to the occur of angina with non-obstructive CAD. Although routine coronary functional assessment is limited due to several disadvantages, functional evaluation can help to understand the pathophysiological mechanism and/or to exclude specific etiologies. In this review, we summarized the potential mechanisms involved in ischemia with non-obstructive coronary arteries (INOCA) and myocardial infarction with non-obstructive coronary arteries (MINOCA), the two major form of non-obstructive CAD. Additionally, we reviewed currently available functional assessment indices and their use in non-obstructive CAD. Furthermore, we speculated that novel technique combined anatomic and physiologic parameters might provide more individualized therapeutic choice for patients with non-obstructive CAD. |
| first_indexed | 2024-04-13T18:29:45Z |
| format | Article |
| id | doaj.art-b2dfcab2b6d34952bee552c544aa5058 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-13T18:29:45Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-b2dfcab2b6d34952bee552c544aa50582022-12-22T02:35:08ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-08-01910.3389/fcvm.2022.934279934279Coronary functional assessment in non-obstructive coronary artery disease: Present situation and future directionChanglin Zhai0Hongyan Fan1Yujuan Zhu2Yunqing Chen3Liang Shen4Department of Cardiology, Affiliated Hospital of Jiaxing University, Jiaxing, ChinaDepartment of Cardiology, Affiliated Hospital of Jiaxing University, Jiaxing, ChinaDepartment of Cardiology, Affiliated Hospital of Jiaxing University, Jiaxing, ChinaDepartment of Infectious Diseases, Affiliated Hospital of Jiaxing University, Jiaxing, ChinaDepartment of Cardiology, Affiliated Hospital of Jiaxing University, Jiaxing, ChinaNon-obstructive coronary artery disease (CAD), which is defined as coronary stenosis <50%, has been increasingly recognized as an emerging entity in clinical practice. Vasomotion abnormality and coronary microvascular dysfunction are two major mechanisms contributing to the occur of angina with non-obstructive CAD. Although routine coronary functional assessment is limited due to several disadvantages, functional evaluation can help to understand the pathophysiological mechanism and/or to exclude specific etiologies. In this review, we summarized the potential mechanisms involved in ischemia with non-obstructive coronary arteries (INOCA) and myocardial infarction with non-obstructive coronary arteries (MINOCA), the two major form of non-obstructive CAD. Additionally, we reviewed currently available functional assessment indices and their use in non-obstructive CAD. Furthermore, we speculated that novel technique combined anatomic and physiologic parameters might provide more individualized therapeutic choice for patients with non-obstructive CAD.https://www.frontiersin.org/articles/10.3389/fcvm.2022.934279/fullcoronary functional assessmentINOCAMINOCAmicrovascular dysfunctionvasomotion abnormality |
| spellingShingle | Changlin Zhai Hongyan Fan Yujuan Zhu Yunqing Chen Liang Shen Coronary functional assessment in non-obstructive coronary artery disease: Present situation and future direction Frontiers in Cardiovascular Medicine coronary functional assessment INOCA MINOCA microvascular dysfunction vasomotion abnormality |
| title | Coronary functional assessment in non-obstructive coronary artery disease: Present situation and future direction |
| title_full | Coronary functional assessment in non-obstructive coronary artery disease: Present situation and future direction |
| title_fullStr | Coronary functional assessment in non-obstructive coronary artery disease: Present situation and future direction |
| title_full_unstemmed | Coronary functional assessment in non-obstructive coronary artery disease: Present situation and future direction |
| title_short | Coronary functional assessment in non-obstructive coronary artery disease: Present situation and future direction |
| title_sort | coronary functional assessment in non obstructive coronary artery disease present situation and future direction |
| topic | coronary functional assessment INOCA MINOCA microvascular dysfunction vasomotion abnormality |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.934279/full |
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