Distinct conformational and functional effects of two adjacent pathogenic mutations in cardiac troponin I at the interface with troponin T
The α‐helix in troponin I (TnI) at the interface with troponin T (TnT) is a highly conserved structure. A point mutation in this region, A116G, was found in human cardiac TnI in a case of cardiomyopathy. An adjacent dominantly negative mutation found in turkey cardiac TnI (R111C, equivalent to K117C...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
Wiley
2015-01-01
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Series: | FEBS Open Bio |
Subjects: | |
Online Access: | https://doi.org/10.1016/j.fob.2015.01.001 |