Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2H)-3-one derivatives
Several 6-aryl-4-substituted benzylidene/furfurylidene pyridazin(2H)-3-one derivatives (4a-f) were synthesized and evaluated as analgesic and anti-inflammatory agents in mice and rats, respectively. All compounds were tested by using Eddy's hot plate and the carrageenan-induced hind paw oedema...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2013-12-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000400030&lng=en&tlng=en |
| _version_ | 1828952092033679360 |
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| author | Anita Singh Lakshmayya Mohammad Asif |
| author_facet | Anita Singh Lakshmayya Mohammad Asif |
| author_sort | Anita Singh |
| collection | DOAJ |
| description | Several 6-aryl-4-substituted benzylidene/furfurylidene pyridazin(2H)-3-one derivatives (4a-f) were synthesized and evaluated as analgesic and anti-inflammatory agents in mice and rats, respectively. All compounds were tested by using Eddy's hot plate and the carrageenan-induced hind paw oedema method for the evaluation of analgesic and anti-inflammatory activities, respectively. Results showed that compounds 4f, 4b, 4d, and 4e exhibited higher analgesic and anti-inflammatory activities than other remaining compounds. All title compounds (4a-f) were characterized by IR, NMR and Mass spectroscopy. |
| first_indexed | 2024-12-14T06:47:17Z |
| format | Article |
| id | doaj.art-b2e1c665736645648dc2849220e28390 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-12-14T06:47:17Z |
| publishDate | 2013-12-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-b2e1c665736645648dc2849220e283902022-12-21T23:13:00ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902013-12-0149490390910.1590/S1984-82502013000400030S1984-82502013000400030Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2H)-3-one derivativesAnita Singh0Lakshmayya1Mohammad Asif2Institute of Management and TechnologyKumaun UniversityKumaun UniversitySeveral 6-aryl-4-substituted benzylidene/furfurylidene pyridazin(2H)-3-one derivatives (4a-f) were synthesized and evaluated as analgesic and anti-inflammatory agents in mice and rats, respectively. All compounds were tested by using Eddy's hot plate and the carrageenan-induced hind paw oedema method for the evaluation of analgesic and anti-inflammatory activities, respectively. Results showed that compounds 4f, 4b, 4d, and 4e exhibited higher analgesic and anti-inflammatory activities than other remaining compounds. All title compounds (4a-f) were characterized by IR, NMR and Mass spectroscopy.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000400030&lng=en&tlng=enPiridazinonaPiridazinonaAnalgésicosAnalgésicosAnti-inflamatóriosAnti-inflamatóriosCompostos sintéticosCompostos sintéticos |
| spellingShingle | Anita Singh Lakshmayya Mohammad Asif Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2H)-3-one derivatives Brazilian Journal of Pharmaceutical Sciences Piridazinona Piridazinona Analgésicos Analgésicos Anti-inflamatórios Anti-inflamatórios Compostos sintéticos Compostos sintéticos |
| title | Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2H)-3-one derivatives |
| title_full | Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2H)-3-one derivatives |
| title_fullStr | Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2H)-3-one derivatives |
| title_full_unstemmed | Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2H)-3-one derivatives |
| title_short | Analgesic and anti-inflammatory activities of several 4-substituted-6-(3'-nitrophenyl)pyridazin-(2H)-3-one derivatives |
| title_sort | analgesic and anti inflammatory activities of several 4 substituted 6 3 nitrophenyl pyridazin 2h 3 one derivatives |
| topic | Piridazinona Piridazinona Analgésicos Analgésicos Anti-inflamatórios Anti-inflamatórios Compostos sintéticos Compostos sintéticos |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000400030&lng=en&tlng=en |
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