Synthesis, spectral characterization and biological evaluation of 1-thiocarbamoyl-3-phenyl-5-hydroxy-5-(-2-pyridyl)-4-pyrazolines via Michael addition
A series of 1-thiocarbamoyl-3-phenyl-5-hydroxy-5-(2-pyridyl)-4-pyrazolines derivatives have been synthesized using sodium acetate as a catalyst. The spectral characterization and structure of 1-thiocarbamoyl-3-phenyl-5-hydroxy-5-(2-pyridyl)-4-pyrazolines are reported. Spectral techniques employed in...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-09-01
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| Series: | Journal of Saudi Chemical Society |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610313000501 |
| _version_ | 1819034277752340480 |
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| author | D. Chinnaraja R. Rajalakshmi V. Latha H. Manikandan |
| author_facet | D. Chinnaraja R. Rajalakshmi V. Latha H. Manikandan |
| author_sort | D. Chinnaraja |
| collection | DOAJ |
| description | A series of 1-thiocarbamoyl-3-phenyl-5-hydroxy-5-(2-pyridyl)-4-pyrazolines derivatives have been synthesized using sodium acetate as a catalyst. The spectral characterization and structure of 1-thiocarbamoyl-3-phenyl-5-hydroxy-5-(2-pyridyl)-4-pyrazolines are reported. Spectral techniques employed include 1H NMR, 13C NMR, 1H–1H COSY, HSQC, HMBC, D2O exchange, Mass and IR. Compounds 12–22 exhibited potent antibacterial activity against Salmonella typhi and Pseudomonas aeruginosa whereas the same set of compounds exerted potent antifungal activity against Aspergillus niger and Aspergillus fumigatus. |
| first_indexed | 2024-12-21T07:31:11Z |
| format | Article |
| id | doaj.art-b2e363df402d4f3f9861795a26125eee |
| institution | Directory Open Access Journal |
| issn | 1319-6103 |
| language | English |
| last_indexed | 2024-12-21T07:31:11Z |
| publishDate | 2016-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj.art-b2e363df402d4f3f9861795a26125eee2022-12-21T19:11:34ZengElsevierJournal of Saudi Chemical Society1319-61032016-09-0120S1S599S60510.1016/j.jscs.2013.04.006Synthesis, spectral characterization and biological evaluation of 1-thiocarbamoyl-3-phenyl-5-hydroxy-5-(-2-pyridyl)-4-pyrazolines via Michael additionD. ChinnarajaR. RajalakshmiV. LathaH. ManikandanA series of 1-thiocarbamoyl-3-phenyl-5-hydroxy-5-(2-pyridyl)-4-pyrazolines derivatives have been synthesized using sodium acetate as a catalyst. The spectral characterization and structure of 1-thiocarbamoyl-3-phenyl-5-hydroxy-5-(2-pyridyl)-4-pyrazolines are reported. Spectral techniques employed include 1H NMR, 13C NMR, 1H–1H COSY, HSQC, HMBC, D2O exchange, Mass and IR. Compounds 12–22 exhibited potent antibacterial activity against Salmonella typhi and Pseudomonas aeruginosa whereas the same set of compounds exerted potent antifungal activity against Aspergillus niger and Aspergillus fumigatus.http://www.sciencedirect.com/science/article/pii/S13196103130005014-PyrazolineThiocarbamoylMichael addition2-Pyridyl chalconeAntibacterial activities |
| spellingShingle | D. Chinnaraja R. Rajalakshmi V. Latha H. Manikandan Synthesis, spectral characterization and biological evaluation of 1-thiocarbamoyl-3-phenyl-5-hydroxy-5-(-2-pyridyl)-4-pyrazolines via Michael addition Journal of Saudi Chemical Society 4-Pyrazoline Thiocarbamoyl Michael addition 2-Pyridyl chalcone Antibacterial activities |
| title | Synthesis, spectral characterization and biological evaluation of 1-thiocarbamoyl-3-phenyl-5-hydroxy-5-(-2-pyridyl)-4-pyrazolines via Michael addition |
| title_full | Synthesis, spectral characterization and biological evaluation of 1-thiocarbamoyl-3-phenyl-5-hydroxy-5-(-2-pyridyl)-4-pyrazolines via Michael addition |
| title_fullStr | Synthesis, spectral characterization and biological evaluation of 1-thiocarbamoyl-3-phenyl-5-hydroxy-5-(-2-pyridyl)-4-pyrazolines via Michael addition |
| title_full_unstemmed | Synthesis, spectral characterization and biological evaluation of 1-thiocarbamoyl-3-phenyl-5-hydroxy-5-(-2-pyridyl)-4-pyrazolines via Michael addition |
| title_short | Synthesis, spectral characterization and biological evaluation of 1-thiocarbamoyl-3-phenyl-5-hydroxy-5-(-2-pyridyl)-4-pyrazolines via Michael addition |
| title_sort | synthesis spectral characterization and biological evaluation of 1 thiocarbamoyl 3 phenyl 5 hydroxy 5 2 pyridyl 4 pyrazolines via michael addition |
| topic | 4-Pyrazoline Thiocarbamoyl Michael addition 2-Pyridyl chalcone Antibacterial activities |
| url | http://www.sciencedirect.com/science/article/pii/S1319610313000501 |
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