Circular RNAs in glioma: Molecular functions and pathological implications
Circular RNAs (circRNAs) are a special class of non-coding RNAs with the ring structure. They are stable, abundant and conservative across mammals. The biogenesis and molecular properties of circRNAs are being elucidated, which exert regulatory functions not only through miRNA and protein sponge, bu...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2024-03-01
|
| Series: | Non-coding RNA Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054023000689 |
| _version_ | 1797267203169452032 |
|---|---|
| author | Cheng Tang Xinyi He Lintao Jia Xiao Zhang |
| author_facet | Cheng Tang Xinyi He Lintao Jia Xiao Zhang |
| author_sort | Cheng Tang |
| collection | DOAJ |
| description | Circular RNAs (circRNAs) are a special class of non-coding RNAs with the ring structure. They are stable, abundant and conservative across mammals. The biogenesis and molecular properties of circRNAs are being elucidated, which exert regulatory functions not only through miRNA and protein sponge, but also via translation and exosomal interaction. Accumulating studies have demonstrated that circRNAs are aberrantly expressed in various diseases, especially in cancer. Glioma is one of the most common malignant cerebral neoplasms with poor prognosis. The accurate diagnosis and effective therapies of glioma have always been challenged, there is an urgent need for developing promising therapeutic intervention. Therefore, exploring novel biomarkers is crucial for diagnosis, treatment and prognosis of the glioma which can provide better assistance in guiding treatment. Recent findings found that circRNAs are systematically altered in glioma and may play critical roles in glioma tumorigenesis, proliferation, invasion and metastasis. Due to their distinct functional properties, they are considered as the potential therapeutic targets, diagnostic and prognostic biomarkers. This review elaborates on current advances towards the biogenesis, translation and interaction of circRNAs in many diseases and focused on the role of their involvement in glioma progression, highlighting the potential value of circRNAs in glioma. |
| first_indexed | 2024-03-10T04:31:07Z |
| format | Article |
| id | doaj.art-b2e5504a7996438fb8fd440ee09ae44d |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2024-04-25T01:12:51Z |
| publishDate | 2024-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj.art-b2e5504a7996438fb8fd440ee09ae44d2024-03-10T05:12:26ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402024-03-0191105115Circular RNAs in glioma: Molecular functions and pathological implicationsCheng Tang0Xinyi He1Lintao Jia2Xiao Zhang3Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, 710032, ChinaDepartment of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, 710032, ChinaCorresponding author.; Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, 710032, ChinaCorresponding author. Department of Biochemistry and Molecular Biology, Fourth Military Medical University, No.169, Changle Road, 710032, Xi'an, China.; Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, 710032, ChinaCircular RNAs (circRNAs) are a special class of non-coding RNAs with the ring structure. They are stable, abundant and conservative across mammals. The biogenesis and molecular properties of circRNAs are being elucidated, which exert regulatory functions not only through miRNA and protein sponge, but also via translation and exosomal interaction. Accumulating studies have demonstrated that circRNAs are aberrantly expressed in various diseases, especially in cancer. Glioma is one of the most common malignant cerebral neoplasms with poor prognosis. The accurate diagnosis and effective therapies of glioma have always been challenged, there is an urgent need for developing promising therapeutic intervention. Therefore, exploring novel biomarkers is crucial for diagnosis, treatment and prognosis of the glioma which can provide better assistance in guiding treatment. Recent findings found that circRNAs are systematically altered in glioma and may play critical roles in glioma tumorigenesis, proliferation, invasion and metastasis. Due to their distinct functional properties, they are considered as the potential therapeutic targets, diagnostic and prognostic biomarkers. This review elaborates on current advances towards the biogenesis, translation and interaction of circRNAs in many diseases and focused on the role of their involvement in glioma progression, highlighting the potential value of circRNAs in glioma.http://www.sciencedirect.com/science/article/pii/S2468054023000689Circular RNA (circRNA)GliomaDiagnosisPrognosisTherapeutic targets |
| spellingShingle | Cheng Tang Xinyi He Lintao Jia Xiao Zhang Circular RNAs in glioma: Molecular functions and pathological implications Non-coding RNA Research Circular RNA (circRNA) Glioma Diagnosis Prognosis Therapeutic targets |
| title | Circular RNAs in glioma: Molecular functions and pathological implications |
| title_full | Circular RNAs in glioma: Molecular functions and pathological implications |
| title_fullStr | Circular RNAs in glioma: Molecular functions and pathological implications |
| title_full_unstemmed | Circular RNAs in glioma: Molecular functions and pathological implications |
| title_short | Circular RNAs in glioma: Molecular functions and pathological implications |
| title_sort | circular rnas in glioma molecular functions and pathological implications |
| topic | Circular RNA (circRNA) Glioma Diagnosis Prognosis Therapeutic targets |
| url | http://www.sciencedirect.com/science/article/pii/S2468054023000689 |
| work_keys_str_mv | AT chengtang circularrnasingliomamolecularfunctionsandpathologicalimplications AT xinyihe circularrnasingliomamolecularfunctionsandpathologicalimplications AT lintaojia circularrnasingliomamolecularfunctionsandpathologicalimplications AT xiaozhang circularrnasingliomamolecularfunctionsandpathologicalimplications |