Inhibitory Effects of Trifluoperazine on Peripheral Proinflammatory Cytokine Expression and Hypothalamic Microglia Activation in Obese Mice Induced by Chronic Feeding With High-Fat-Diet

Inhibitory Effects of Trifluoperazine on Peripheral Proinflammatory Cytokine Expression and Hypothalamic Microglia Activation in Obese Mice Induced by Chronic Feeding With High-Fat-Diet

Microglia and astrocytes are the glial cells of the central nervous system (CNS) to support neurodevelopment and neuronal function. Yet, their activation in association with CNS inflammation is involved in the initiation and progression of neurological disorders. Mild inflammation in the periphery a...

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Bibliographic Details
Main Authors: Hui-Ting Huang, Pei-Chun Chen, Po-See Chen, Wen-Tai Chiu, Yu-Min Kuo, Shun-Fen Tzeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
inflammation
cytokine
microglia
gliosis
dopamine type 2 receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.752771/full

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