Black Cumin Seed (<i>Nigella sativa</i>) in Inflammatory Disorders: Therapeutic Potential and Promising Molecular Mechanisms
Inflammation is an essential defense mechanism against harmful stimuli. However, uncontrolled inflammatory mechanisms culminate in disturbed responses that contribute to multiple serious diseases. Besides common synthetic drugs, there is a growing interest in optimizing the use of natural products a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Drugs and Drug Candidates |
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| Online Access: | https://www.mdpi.com/2813-2998/2/2/27 |
| _version_ | 1797586967196598272 |
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| author | Hager K. Rashwan Shahenda Mahgoub Nermeen Z. Abuelezz Hatem K. Amin |
| author_facet | Hager K. Rashwan Shahenda Mahgoub Nermeen Z. Abuelezz Hatem K. Amin |
| author_sort | Hager K. Rashwan |
| collection | DOAJ |
| description | Inflammation is an essential defense mechanism against harmful stimuli. However, uncontrolled inflammatory mechanisms culminate in disturbed responses that contribute to multiple serious diseases. Besides common synthetic drugs, there is a growing interest in optimizing the use of natural products as therapeutic or protective supplements against inflammatory disorders. Black cumin seed (BCS), or <i>Nigella sativa</i> (Family Ranunculaceae), is widely used as a health-supportive herb in the Middle East, Far East and West Asia. BCS is a rich source of phytochemicals, and studies have reported its promising effects against a variety of metabolic, proliferative, respiratory, and neurological disorders associated with disrupted inflammatory pathways. This review presents an updated comprehensive assessment of BCS’s effects against various inflammatory disorders and highlights the role of BCS’s bioactive constituents in inflammation and oxidative stress pathways. Moreover, it outlines the future possibilities for enhancing therapeutic activity through efficient pharmaceutical formulations. Thorough analysis of international research studies published between the years 1998 and 2023 reveals the promising anti-inflammatory potential of BCS’s bioactive constituents through modulating inflammation and crucial oxidative stress players in inflammatory disorders. Thus, the bioactive constituents of BCS can be further boosted by updated technologies such as nano-incorporation for the improved management of inflammatory diseases. |
| first_indexed | 2024-03-11T00:29:42Z |
| format | Article |
| id | doaj.art-b2e662acd8994a2994564ef14277b1dc |
| institution | Directory Open Access Journal |
| issn | 2813-2998 |
| language | English |
| last_indexed | 2024-03-11T00:29:42Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Drugs and Drug Candidates |
| spelling | doaj.art-b2e662acd8994a2994564ef14277b1dc2023-11-18T22:45:54ZengMDPI AGDrugs and Drug Candidates2813-29982023-06-012251653710.3390/ddc2020027Black Cumin Seed (<i>Nigella sativa</i>) in Inflammatory Disorders: Therapeutic Potential and Promising Molecular MechanismsHager K. Rashwan0Shahenda Mahgoub1Nermeen Z. Abuelezz2Hatem K. Amin3Biochemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza 12585, EgyptBiochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Cairo 11795, EgyptBiochemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza 12585, EgyptBiochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Cairo 11795, EgyptInflammation is an essential defense mechanism against harmful stimuli. However, uncontrolled inflammatory mechanisms culminate in disturbed responses that contribute to multiple serious diseases. Besides common synthetic drugs, there is a growing interest in optimizing the use of natural products as therapeutic or protective supplements against inflammatory disorders. Black cumin seed (BCS), or <i>Nigella sativa</i> (Family Ranunculaceae), is widely used as a health-supportive herb in the Middle East, Far East and West Asia. BCS is a rich source of phytochemicals, and studies have reported its promising effects against a variety of metabolic, proliferative, respiratory, and neurological disorders associated with disrupted inflammatory pathways. This review presents an updated comprehensive assessment of BCS’s effects against various inflammatory disorders and highlights the role of BCS’s bioactive constituents in inflammation and oxidative stress pathways. Moreover, it outlines the future possibilities for enhancing therapeutic activity through efficient pharmaceutical formulations. Thorough analysis of international research studies published between the years 1998 and 2023 reveals the promising anti-inflammatory potential of BCS’s bioactive constituents through modulating inflammation and crucial oxidative stress players in inflammatory disorders. Thus, the bioactive constituents of BCS can be further boosted by updated technologies such as nano-incorporation for the improved management of inflammatory diseases.https://www.mdpi.com/2813-2998/2/2/27cytokinesinflammationoxidative stressnatural productsnano formulations |
| spellingShingle | Hager K. Rashwan Shahenda Mahgoub Nermeen Z. Abuelezz Hatem K. Amin Black Cumin Seed (<i>Nigella sativa</i>) in Inflammatory Disorders: Therapeutic Potential and Promising Molecular Mechanisms Drugs and Drug Candidates cytokines inflammation oxidative stress natural products nano formulations |
| title | Black Cumin Seed (<i>Nigella sativa</i>) in Inflammatory Disorders: Therapeutic Potential and Promising Molecular Mechanisms |
| title_full | Black Cumin Seed (<i>Nigella sativa</i>) in Inflammatory Disorders: Therapeutic Potential and Promising Molecular Mechanisms |
| title_fullStr | Black Cumin Seed (<i>Nigella sativa</i>) in Inflammatory Disorders: Therapeutic Potential and Promising Molecular Mechanisms |
| title_full_unstemmed | Black Cumin Seed (<i>Nigella sativa</i>) in Inflammatory Disorders: Therapeutic Potential and Promising Molecular Mechanisms |
| title_short | Black Cumin Seed (<i>Nigella sativa</i>) in Inflammatory Disorders: Therapeutic Potential and Promising Molecular Mechanisms |
| title_sort | black cumin seed i nigella sativa i in inflammatory disorders therapeutic potential and promising molecular mechanisms |
| topic | cytokines inflammation oxidative stress natural products nano formulations |
| url | https://www.mdpi.com/2813-2998/2/2/27 |
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