YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development

Formation of blood vessel networks by sprouting angiogenesis is critical for tissue growth, homeostasis and regeneration. How endothelial cells arise in adequate numbers and arrange suitably to shape functional vascular networks is poorly understood. Here we show that YAP/TAZ promote stretch-induced...

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Bibliographic Details
Main Authors: Filipa Neto, Alexandra Klaus-Bergmann, Yu Ting Ong, Silvanus Alt, Anne-Clémence Vion, Anna Szymborska, Joana R Carvalho, Irene Hollfinger, Eireen Bartels-Klein, Claudio A Franco, Michael Potente, Holger Gerhardt
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
vascular development
YAP
TAZ
VE-Cadherin
BMP
Online Access:https://elifesciences.org/articles/31037

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