Metabolic dynamics in astrocytes and microglia during post-natal development and their implications for autism spectrum disorders
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by elusive underlying mechanisms. Recent attention has focused on the involvement of astrocytes and microglia in ASD pathology. These glial cells play pivotal roles in maintaining neuronal homeostasis, including t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2024.1354259/full |
| _version_ | 1797311669562507264 |
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| author | Iva Cantando Cristiana Centofanti Giuseppina D’Alessandro Giuseppina D’Alessandro Cristina Limatola Cristina Limatola Paola Bezzi Paola Bezzi |
| author_facet | Iva Cantando Cristiana Centofanti Giuseppina D’Alessandro Giuseppina D’Alessandro Cristina Limatola Cristina Limatola Paola Bezzi Paola Bezzi |
| author_sort | Iva Cantando |
| collection | DOAJ |
| description | Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by elusive underlying mechanisms. Recent attention has focused on the involvement of astrocytes and microglia in ASD pathology. These glial cells play pivotal roles in maintaining neuronal homeostasis, including the regulation of metabolism. Emerging evidence suggests a potential association between ASD and inborn errors of metabolism. Therefore, gaining a comprehensive understanding of the functions of microglia and astrocytes in ASD is crucial for the development of effective therapeutic interventions. This review aims to provide a summary of the metabolism of astrocytes and microglia during post-natal development and the evidence of disrupted metabolic pathways in ASD, with particular emphasis on those potentially important for the regulation of neuronal post-natal maturation by astrocytes and microglia. |
| first_indexed | 2024-03-08T02:03:03Z |
| format | Article |
| id | doaj.art-b2e69c9bb3d44627b25390a2a0010c3a |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-03-08T02:03:03Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-b2e69c9bb3d44627b25390a2a0010c3a2024-02-14T04:18:46ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022024-02-011810.3389/fncel.2024.13542591354259Metabolic dynamics in astrocytes and microglia during post-natal development and their implications for autism spectrum disordersIva Cantando0Cristiana Centofanti1Giuseppina D’Alessandro2Giuseppina D’Alessandro3Cristina Limatola4Cristina Limatola5Paola Bezzi6Paola Bezzi7Department of Fundamental Neurosciences (DNF), University of Lausanne, Lausanne, SwitzerlandDepartment of Fundamental Neurosciences (DNF), University of Lausanne, Lausanne, SwitzerlandDepartment of Physiology and Pharmacology, University of Rome Sapienza, Rome, ItalyIstituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Neuromed Via Atinese 18, Pozzilli, ItalyDepartment of Physiology and Pharmacology, University of Rome Sapienza, Rome, ItalyIstituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Neuromed Via Atinese 18, Pozzilli, ItalyDepartment of Fundamental Neurosciences (DNF), University of Lausanne, Lausanne, SwitzerlandDepartment of Physiology and Pharmacology, University of Rome Sapienza, Rome, ItalyAutism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by elusive underlying mechanisms. Recent attention has focused on the involvement of astrocytes and microglia in ASD pathology. These glial cells play pivotal roles in maintaining neuronal homeostasis, including the regulation of metabolism. Emerging evidence suggests a potential association between ASD and inborn errors of metabolism. Therefore, gaining a comprehensive understanding of the functions of microglia and astrocytes in ASD is crucial for the development of effective therapeutic interventions. This review aims to provide a summary of the metabolism of astrocytes and microglia during post-natal development and the evidence of disrupted metabolic pathways in ASD, with particular emphasis on those potentially important for the regulation of neuronal post-natal maturation by astrocytes and microglia.https://www.frontiersin.org/articles/10.3389/fncel.2024.1354259/fullastrocytemicrogliamitochondriabrain metabolismfatty acid oxidationlipids |
| spellingShingle | Iva Cantando Cristiana Centofanti Giuseppina D’Alessandro Giuseppina D’Alessandro Cristina Limatola Cristina Limatola Paola Bezzi Paola Bezzi Metabolic dynamics in astrocytes and microglia during post-natal development and their implications for autism spectrum disorders Frontiers in Cellular Neuroscience astrocyte microglia mitochondria brain metabolism fatty acid oxidation lipids |
| title | Metabolic dynamics in astrocytes and microglia during post-natal development and their implications for autism spectrum disorders |
| title_full | Metabolic dynamics in astrocytes and microglia during post-natal development and their implications for autism spectrum disorders |
| title_fullStr | Metabolic dynamics in astrocytes and microglia during post-natal development and their implications for autism spectrum disorders |
| title_full_unstemmed | Metabolic dynamics in astrocytes and microglia during post-natal development and their implications for autism spectrum disorders |
| title_short | Metabolic dynamics in astrocytes and microglia during post-natal development and their implications for autism spectrum disorders |
| title_sort | metabolic dynamics in astrocytes and microglia during post natal development and their implications for autism spectrum disorders |
| topic | astrocyte microglia mitochondria brain metabolism fatty acid oxidation lipids |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2024.1354259/full |
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