Autoimmune Addison's Disease as Part of the Autoimmune Polyglandular Syndrome Type 1: Historical Overview and Current Evidence

Autoimmune Addison's Disease as Part of the Autoimmune Polyglandular Syndrome Type 1: Historical Overview and Current Evidence

The autoimmune polyglandular syndrome type 1 (APS1) is caused by pathogenic variants of the autoimmune regulator (AIRE) gene, located in the chromosomal region 21q22.3. The related protein, AIRE, enhances thymic self-representation and immune self-tolerance by localization to chromatin and anchorage...

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Bibliographic Details
Main Authors: Roberto Perniola, Alessandra Fierabracci, Alberto Falorni
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
Addison's disease
autoimmune polyendocrinopathies
cytochrome P450 enzyme system
history
transcription factors
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.606860/full

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