Carbon Monoxide Controllable Targeted Gas Therapy for Synergistic Anti-inflammation
Summary: Carbon monoxide (CO) plays an important role in the regulation of a variety of physiological processes and thus is regarded as a promising pharmaceutical agent. Nevertheless, therapeutic applications of CO are severely hampered by the difficulty of the delivery of controlled amounts of CO t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004220306751 |
| _version_ | 1828415122478989312 |
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| author | Chun Liu Zhi Du Mengmeng Ma Yuhuan Sun Jinsong Ren Xiaogang Qu |
| author_facet | Chun Liu Zhi Du Mengmeng Ma Yuhuan Sun Jinsong Ren Xiaogang Qu |
| author_sort | Chun Liu |
| collection | DOAJ |
| description | Summary: Carbon monoxide (CO) plays an important role in the regulation of a variety of physiological processes and thus is regarded as a promising pharmaceutical agent. Nevertheless, therapeutic applications of CO are severely hampered by the difficulty of the delivery of controlled amounts of CO to biological targets. To address this deficiency, we present a spatiotemporally controllable CO-releasing platform (designated as Neu-MnO2/Fla) for synergistic anti-inflammation. With the assistance of neutrophil membrane coating, Neu-MnO2/Fla can target to inflammatory sites. Subsequently, excess H2O2 at the inflamed tissues can be decomposed into oxygen because of MnO2 as nanozymes possessing catalase (CAT) activity, which not only relieves oxidative stress but also achieves in situ rapid photo-induced CO release. The in vitro and in vivo results indicate our CO-releasing platform exhibits a strong synergistic anti-inflammatory effect. Our work will shed light on targeted CO release to avoid side effects of therapeutic applications of CO. |
| first_indexed | 2024-12-10T13:39:07Z |
| format | Article |
| id | doaj.art-b2e799eab443450a8672a6d3140edbc0 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-10T13:39:07Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-b2e799eab443450a8672a6d3140edbc02022-12-22T01:46:45ZengElsevieriScience2589-00422020-09-01239101483Carbon Monoxide Controllable Targeted Gas Therapy for Synergistic Anti-inflammationChun Liu0Zhi Du1Mengmeng Ma2Yuhuan Sun3Jinsong Ren4Xiaogang Qu5Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China; University of Science and Technology of China, Hefei, Anhui 230026, ChinaLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China; University of Chinese Academy of Sciences, Beijing 100039, ChinaLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China; University of Science and Technology of China, Hefei, Anhui 230026, ChinaLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China; University of Science and Technology of China, Hefei, Anhui 230026, ChinaLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China; University of Science and Technology of China, Hefei, Anhui 230026, ChinaLaboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China; University of Science and Technology of China, Hefei, Anhui 230026, China; Corresponding authorSummary: Carbon monoxide (CO) plays an important role in the regulation of a variety of physiological processes and thus is regarded as a promising pharmaceutical agent. Nevertheless, therapeutic applications of CO are severely hampered by the difficulty of the delivery of controlled amounts of CO to biological targets. To address this deficiency, we present a spatiotemporally controllable CO-releasing platform (designated as Neu-MnO2/Fla) for synergistic anti-inflammation. With the assistance of neutrophil membrane coating, Neu-MnO2/Fla can target to inflammatory sites. Subsequently, excess H2O2 at the inflamed tissues can be decomposed into oxygen because of MnO2 as nanozymes possessing catalase (CAT) activity, which not only relieves oxidative stress but also achieves in situ rapid photo-induced CO release. The in vitro and in vivo results indicate our CO-releasing platform exhibits a strong synergistic anti-inflammatory effect. Our work will shed light on targeted CO release to avoid side effects of therapeutic applications of CO.http://www.sciencedirect.com/science/article/pii/S2589004220306751ChemistryBiochemistryNanotechnology |
| spellingShingle | Chun Liu Zhi Du Mengmeng Ma Yuhuan Sun Jinsong Ren Xiaogang Qu Carbon Monoxide Controllable Targeted Gas Therapy for Synergistic Anti-inflammation iScience Chemistry Biochemistry Nanotechnology |
| title | Carbon Monoxide Controllable Targeted Gas Therapy for Synergistic Anti-inflammation |
| title_full | Carbon Monoxide Controllable Targeted Gas Therapy for Synergistic Anti-inflammation |
| title_fullStr | Carbon Monoxide Controllable Targeted Gas Therapy for Synergistic Anti-inflammation |
| title_full_unstemmed | Carbon Monoxide Controllable Targeted Gas Therapy for Synergistic Anti-inflammation |
| title_short | Carbon Monoxide Controllable Targeted Gas Therapy for Synergistic Anti-inflammation |
| title_sort | carbon monoxide controllable targeted gas therapy for synergistic anti inflammation |
| topic | Chemistry Biochemistry Nanotechnology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004220306751 |
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