Gastric adenocarcinoma of the fundic gland type: clinicopathological features of eight patients treated with endoscopic submucosal dissection
Abstract Background Gastric adenocarcinoma of the fundic gland type (GA-FG) has been added to the 2019 edition of the World Health Organization’s list of digestive system-associated cancers. This lesion differentiates toward the fundic gland and mostly involves chief cell-predominant differentiation...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | Diagnostic Pathology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13000-020-01047-2 |
| _version_ | 1818450048899350528 |
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| author | Chengfang Li Xinglong Wu Shuang Yang Xiaorong Yang Jin Yao Hong Zheng |
| author_facet | Chengfang Li Xinglong Wu Shuang Yang Xiaorong Yang Jin Yao Hong Zheng |
| author_sort | Chengfang Li |
| collection | DOAJ |
| description | Abstract Background Gastric adenocarcinoma of the fundic gland type (GA-FG) has been added to the 2019 edition of the World Health Organization’s list of digestive system-associated cancers. This lesion differentiates toward the fundic gland and mostly involves chief cell-predominant differentiation with low-grade cytology. Clinicians and pathologists are still unaware of this rare disease; consequently, some cases are incorrectly diagnosed. This study aimed to investigate the clinicopathological features of GA-FG using retrospective analyses of endoscopic and pathological findings. Materials and methods Samples were collected from patients diagnosed with GA-FG. The clinical courses of all patients were monitored prospectively and reviewed retrospectively. Available clinical information, endoscopic features, pathological appearance, and follow-up data were assessed. Immunohistochemistry [mucin (MUC) 2, MUC5, MUC6, P53, CDX2, Ki67, SYN, CD56, CGA, β-catenin, and pepsinogen-I] was examined using Envision two-step method. Results Eight cases of endoscopic submucosal dissection (ESD) were obtained from our institution. Patient age ranged from 48 to 80 years (mean, 65 years). Some patients were on acid-suppressing medication. Most lesions were located in the upper third (n = 7) and one was in the middle third of the stomach. Six lesions were of the superficial flat type, whereas two were of the superficial elevated type. Narrow-band imaging using magnifying endoscopy showed irregular microvascular patterns (MVPs) in four cases and regular MVPs in the remaining cases. All lesions were primarily solitary and ~ 6 mm in diameter (largest, 12 mm). The main body of the tumors were localized in the mucosal layer, of which six cases invade into the submucosal layer. Well-formed glands of chief cells were predominant. Tumor cells were positive for pepsinogen-I, MUC6, SYN, and CD56. Lymphatic and vascular infiltration and metastatic and recurrent disease were not observed in any case. Conclusion GA-FG, a well-differentiated adenocarcinoma with mild atypia, can be completely removed using ESD, with a favorable prognosis in patients. |
| first_indexed | 2024-12-14T20:45:07Z |
| format | Article |
| id | doaj.art-b2e8e70842784b2ba0b2a761100202f8 |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-12-14T20:45:07Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-b2e8e70842784b2ba0b2a761100202f82022-12-21T22:48:06ZengBMCDiagnostic Pathology1746-15962020-10-011511910.1186/s13000-020-01047-2Gastric adenocarcinoma of the fundic gland type: clinicopathological features of eight patients treated with endoscopic submucosal dissectionChengfang Li0Xinglong Wu1Shuang Yang2Xiaorong Yang3Jin Yao4Hong Zheng5Department of Pathology, Affiliated Hospital of Zunyi Medical UniversityDepartment of Pathology, Affiliated Hospital of Zunyi Medical UniversityDepartment of Pathology, Affiliated Hospital of Zunyi Medical UniversityDepartment of Pathology, Affiliated Hospital of Zunyi Medical UniversityDepartment of Pathology, Affiliated Hospital of Zunyi Medical UniversityDepartment of Pathology, Affiliated Hospital of Zunyi Medical UniversityAbstract Background Gastric adenocarcinoma of the fundic gland type (GA-FG) has been added to the 2019 edition of the World Health Organization’s list of digestive system-associated cancers. This lesion differentiates toward the fundic gland and mostly involves chief cell-predominant differentiation with low-grade cytology. Clinicians and pathologists are still unaware of this rare disease; consequently, some cases are incorrectly diagnosed. This study aimed to investigate the clinicopathological features of GA-FG using retrospective analyses of endoscopic and pathological findings. Materials and methods Samples were collected from patients diagnosed with GA-FG. The clinical courses of all patients were monitored prospectively and reviewed retrospectively. Available clinical information, endoscopic features, pathological appearance, and follow-up data were assessed. Immunohistochemistry [mucin (MUC) 2, MUC5, MUC6, P53, CDX2, Ki67, SYN, CD56, CGA, β-catenin, and pepsinogen-I] was examined using Envision two-step method. Results Eight cases of endoscopic submucosal dissection (ESD) were obtained from our institution. Patient age ranged from 48 to 80 years (mean, 65 years). Some patients were on acid-suppressing medication. Most lesions were located in the upper third (n = 7) and one was in the middle third of the stomach. Six lesions were of the superficial flat type, whereas two were of the superficial elevated type. Narrow-band imaging using magnifying endoscopy showed irregular microvascular patterns (MVPs) in four cases and regular MVPs in the remaining cases. All lesions were primarily solitary and ~ 6 mm in diameter (largest, 12 mm). The main body of the tumors were localized in the mucosal layer, of which six cases invade into the submucosal layer. Well-formed glands of chief cells were predominant. Tumor cells were positive for pepsinogen-I, MUC6, SYN, and CD56. Lymphatic and vascular infiltration and metastatic and recurrent disease were not observed in any case. Conclusion GA-FG, a well-differentiated adenocarcinoma with mild atypia, can be completely removed using ESD, with a favorable prognosis in patients.http://link.springer.com/article/10.1186/s13000-020-01047-2Gastric adenocarcinoma of the fundic gland typeChief cellsPepsinogen-IEndoscopic submucosal dissectionPathological diagnosisEndoscopic diagnosis |
| spellingShingle | Chengfang Li Xinglong Wu Shuang Yang Xiaorong Yang Jin Yao Hong Zheng Gastric adenocarcinoma of the fundic gland type: clinicopathological features of eight patients treated with endoscopic submucosal dissection Diagnostic Pathology Gastric adenocarcinoma of the fundic gland type Chief cells Pepsinogen-I Endoscopic submucosal dissection Pathological diagnosis Endoscopic diagnosis |
| title | Gastric adenocarcinoma of the fundic gland type: clinicopathological features of eight patients treated with endoscopic submucosal dissection |
| title_full | Gastric adenocarcinoma of the fundic gland type: clinicopathological features of eight patients treated with endoscopic submucosal dissection |
| title_fullStr | Gastric adenocarcinoma of the fundic gland type: clinicopathological features of eight patients treated with endoscopic submucosal dissection |
| title_full_unstemmed | Gastric adenocarcinoma of the fundic gland type: clinicopathological features of eight patients treated with endoscopic submucosal dissection |
| title_short | Gastric adenocarcinoma of the fundic gland type: clinicopathological features of eight patients treated with endoscopic submucosal dissection |
| title_sort | gastric adenocarcinoma of the fundic gland type clinicopathological features of eight patients treated with endoscopic submucosal dissection |
| topic | Gastric adenocarcinoma of the fundic gland type Chief cells Pepsinogen-I Endoscopic submucosal dissection Pathological diagnosis Endoscopic diagnosis |
| url | http://link.springer.com/article/10.1186/s13000-020-01047-2 |
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