Trans-generational Immune Priming in Invertebrates: Current Knowledge and Future Prospects
Trans-generational immune priming (TGIP) refers to the transfer of the parental immunological experience to its progeny. This may result in offspring protection from repeated encounters with pathogens that persist across generations. Although extensively studied in vertebrates for over a century, th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.01938/full |
| _version_ | 1830220610778693632 |
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| author | Guillaume Tetreau Guillaume Tetreau Julien Dhinaut Benjamin Gourbal Yannick Moret |
| author_facet | Guillaume Tetreau Guillaume Tetreau Julien Dhinaut Benjamin Gourbal Yannick Moret |
| author_sort | Guillaume Tetreau |
| collection | DOAJ |
| description | Trans-generational immune priming (TGIP) refers to the transfer of the parental immunological experience to its progeny. This may result in offspring protection from repeated encounters with pathogens that persist across generations. Although extensively studied in vertebrates for over a century, this phenomenon has only been identified 20 years ago in invertebrates. Since then, invertebrate TGIP has been the focus of an increasing interest, with half of studies published during the last few years. TGIP has now been tested in several invertebrate systems using various experimental approaches and measures to study it at both functional and evolutionary levels. However, drawing an overall picture of TGIP from available studies still appears to be a difficult task. Here, we provide a comprehensive review of TGIP in invertebrates with the objective of confronting all the data generated to date to highlight the main features and mechanisms identified in the context of its ecology and evolution. To this purpose, we describe all the articles reporting experimental investigation of TGIP in invertebrates and propose a critical analysis of the experimental procedures performed to study this phenomenon. We then investigate the outcome of TGIP in the offspring and its ecological and evolutionary relevance before reviewing the potential molecular mechanisms identified to date. In the light of this review, we build hypothetical scenarios of the mechanisms through which TGIP might be achieved and propose guidelines for future investigations. |
| first_indexed | 2024-12-18T08:09:18Z |
| format | Article |
| id | doaj.art-b2eb925c38e7476393371d260d2ca476 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-18T08:09:18Z |
| publishDate | 2019-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b2eb925c38e7476393371d260d2ca4762022-12-21T21:14:56ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-08-011010.3389/fimmu.2019.01938473922Trans-generational Immune Priming in Invertebrates: Current Knowledge and Future ProspectsGuillaume Tetreau0Guillaume Tetreau1Julien Dhinaut2Benjamin Gourbal3Yannick Moret4Université de Perpignan Via Domitia, IHPE UMR 5244, CNRS, IFREMER, Univ. Montpellier, Perpignan, FranceUniversité Grenoble Alpes, CNRS, CEA, IBS, Grenoble, FranceUMR CNRS 6282 BioGéoSciences, Équipe Écologie Évolutive, Université Bourgogne-Franche Comté, Dijon, FranceUniversité de Perpignan Via Domitia, IHPE UMR 5244, CNRS, IFREMER, Univ. Montpellier, Perpignan, FranceUMR CNRS 6282 BioGéoSciences, Équipe Écologie Évolutive, Université Bourgogne-Franche Comté, Dijon, FranceTrans-generational immune priming (TGIP) refers to the transfer of the parental immunological experience to its progeny. This may result in offspring protection from repeated encounters with pathogens that persist across generations. Although extensively studied in vertebrates for over a century, this phenomenon has only been identified 20 years ago in invertebrates. Since then, invertebrate TGIP has been the focus of an increasing interest, with half of studies published during the last few years. TGIP has now been tested in several invertebrate systems using various experimental approaches and measures to study it at both functional and evolutionary levels. However, drawing an overall picture of TGIP from available studies still appears to be a difficult task. Here, we provide a comprehensive review of TGIP in invertebrates with the objective of confronting all the data generated to date to highlight the main features and mechanisms identified in the context of its ecology and evolution. To this purpose, we describe all the articles reporting experimental investigation of TGIP in invertebrates and propose a critical analysis of the experimental procedures performed to study this phenomenon. We then investigate the outcome of TGIP in the offspring and its ecological and evolutionary relevance before reviewing the potential molecular mechanisms identified to date. In the light of this review, we build hypothetical scenarios of the mechanisms through which TGIP might be achieved and propose guidelines for future investigations.https://www.frontiersin.org/article/10.3389/fimmu.2019.01938/fulltrans-generational immune priminginvertebrate immunityhost-pathogens interactionecology and evolutionmolecular mechanismsscenarios |
| spellingShingle | Guillaume Tetreau Guillaume Tetreau Julien Dhinaut Benjamin Gourbal Yannick Moret Trans-generational Immune Priming in Invertebrates: Current Knowledge and Future Prospects Frontiers in Immunology trans-generational immune priming invertebrate immunity host-pathogens interaction ecology and evolution molecular mechanisms scenarios |
| title | Trans-generational Immune Priming in Invertebrates: Current Knowledge and Future Prospects |
| title_full | Trans-generational Immune Priming in Invertebrates: Current Knowledge and Future Prospects |
| title_fullStr | Trans-generational Immune Priming in Invertebrates: Current Knowledge and Future Prospects |
| title_full_unstemmed | Trans-generational Immune Priming in Invertebrates: Current Knowledge and Future Prospects |
| title_short | Trans-generational Immune Priming in Invertebrates: Current Knowledge and Future Prospects |
| title_sort | trans generational immune priming in invertebrates current knowledge and future prospects |
| topic | trans-generational immune priming invertebrate immunity host-pathogens interaction ecology and evolution molecular mechanisms scenarios |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.01938/full |
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