Ventilatory efficiency and aerobic capacity in people with multiple sclerosis: A randomized study
Objectives: To assess ventilatory efficiency and aerobic capacity in people with multiple sclerosis and whether treadmill walking or progressive strength training has an effect on these parameters in this population. Methods: In all, 24 adults with multiple sclerosis with an Expanded Disability Stat...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-12-01
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| Series: | SAGE Open Medicine |
| Online Access: | https://doi.org/10.1177/2050312117743672 |
| _version_ | 1818323163246755840 |
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| author | Stine Maren Riksfjord Siri Merete Brændvik Ola D Røksund Inger-Lise Aamot |
| author_facet | Stine Maren Riksfjord Siri Merete Brændvik Ola D Røksund Inger-Lise Aamot |
| author_sort | Stine Maren Riksfjord |
| collection | DOAJ |
| description | Objectives: To assess ventilatory efficiency and aerobic capacity in people with multiple sclerosis and whether treadmill walking or progressive strength training has an effect on these parameters in this population. Methods: In all, 24 adults with multiple sclerosis with an Expanded Disability Status Scale score of ≤6 completed a cardiopulmonary exercise test before and after 8 weeks of exercise. They were randomized to treadmill walking of low-to-moderate intensity (50%–70% of peak heart rate) or progressive strength training (six repetitions × two at 80% of one repetition maximum). Both groups exercised for 30 min three times per week. Primary outcome measure was ventilatory efficiency measured as the minute ventilation/carbon dioxide production (VE/VCO 2 ) ratio and oxygen uptake efficiency slope. Secondary outcome was aerobic capacity, measured as peak oxygen uptake (VO 2peak ). Results: Despite low aerobic capacity, ventilatory efficiency was found to be within normal range. After 8 weeks of exercise, no significant between-group differences emerged in (1) VE/VCO 2 ratio (26 ± 2.2 to 26 ± 2.0, 29 ± 2.0 to 28 ± 2.3, p = 0.66), (2) oxygen uptake efficiency slope (2697 ± 442 to 2701 ± 577, 2473 ± 800 to 2481 ± 896, p = 0.71), or (3) VO 2peak in mL/kg/min (28 ± 4.4 to 30 ± 4.3, 29 ± 6.7 to 29 ± 6.4, p = 0.38) in treadmill walking and progressive strength training, respectively. There were no significant within-group differences either. No adverse events occurred during cardiopulmonary exercise test or exercise training. Conclusion: In people with mild-to-moderate multiple sclerosis, 8 weeks of treadmill walking of low-to-moderate intensity or progressive strength training did not have any effect on ventilatory efficiency or aerobic capacity. Although aerobic capacity was lower than reference values, ventilatory efficiency was not reduced. |
| first_indexed | 2024-12-13T11:08:19Z |
| format | Article |
| id | doaj.art-b2eed8f6c66a4c0d8fe862ea30ff5cfb |
| institution | Directory Open Access Journal |
| issn | 2050-3121 |
| language | English |
| last_indexed | 2024-12-13T11:08:19Z |
| publishDate | 2017-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medicine |
| spelling | doaj.art-b2eed8f6c66a4c0d8fe862ea30ff5cfb2022-12-21T23:48:54ZengSAGE PublishingSAGE Open Medicine2050-31212017-12-01510.1177/2050312117743672Ventilatory efficiency and aerobic capacity in people with multiple sclerosis: A randomized studyStine Maren Riksfjord0Siri Merete Brændvik1Ola D Røksund2Inger-Lise Aamot3Clinic of Clinical Services, St. Olav’s University Hospital, Trondheim, NorwayDepartment of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, NorwayDepartment of Occupational Therapy, Physiotherapy and Radiography, Bergen University College, Bergen, NorwayK.G. Jebsen Center for Exercise in Medicine, Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, NorwayObjectives: To assess ventilatory efficiency and aerobic capacity in people with multiple sclerosis and whether treadmill walking or progressive strength training has an effect on these parameters in this population. Methods: In all, 24 adults with multiple sclerosis with an Expanded Disability Status Scale score of ≤6 completed a cardiopulmonary exercise test before and after 8 weeks of exercise. They were randomized to treadmill walking of low-to-moderate intensity (50%–70% of peak heart rate) or progressive strength training (six repetitions × two at 80% of one repetition maximum). Both groups exercised for 30 min three times per week. Primary outcome measure was ventilatory efficiency measured as the minute ventilation/carbon dioxide production (VE/VCO 2 ) ratio and oxygen uptake efficiency slope. Secondary outcome was aerobic capacity, measured as peak oxygen uptake (VO 2peak ). Results: Despite low aerobic capacity, ventilatory efficiency was found to be within normal range. After 8 weeks of exercise, no significant between-group differences emerged in (1) VE/VCO 2 ratio (26 ± 2.2 to 26 ± 2.0, 29 ± 2.0 to 28 ± 2.3, p = 0.66), (2) oxygen uptake efficiency slope (2697 ± 442 to 2701 ± 577, 2473 ± 800 to 2481 ± 896, p = 0.71), or (3) VO 2peak in mL/kg/min (28 ± 4.4 to 30 ± 4.3, 29 ± 6.7 to 29 ± 6.4, p = 0.38) in treadmill walking and progressive strength training, respectively. There were no significant within-group differences either. No adverse events occurred during cardiopulmonary exercise test or exercise training. Conclusion: In people with mild-to-moderate multiple sclerosis, 8 weeks of treadmill walking of low-to-moderate intensity or progressive strength training did not have any effect on ventilatory efficiency or aerobic capacity. Although aerobic capacity was lower than reference values, ventilatory efficiency was not reduced.https://doi.org/10.1177/2050312117743672 |
| spellingShingle | Stine Maren Riksfjord Siri Merete Brændvik Ola D Røksund Inger-Lise Aamot Ventilatory efficiency and aerobic capacity in people with multiple sclerosis: A randomized study SAGE Open Medicine |
| title | Ventilatory efficiency and aerobic capacity in people with multiple sclerosis: A randomized study |
| title_full | Ventilatory efficiency and aerobic capacity in people with multiple sclerosis: A randomized study |
| title_fullStr | Ventilatory efficiency and aerobic capacity in people with multiple sclerosis: A randomized study |
| title_full_unstemmed | Ventilatory efficiency and aerobic capacity in people with multiple sclerosis: A randomized study |
| title_short | Ventilatory efficiency and aerobic capacity in people with multiple sclerosis: A randomized study |
| title_sort | ventilatory efficiency and aerobic capacity in people with multiple sclerosis a randomized study |
| url | https://doi.org/10.1177/2050312117743672 |
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