An Efficient Nomogram to Predict Overall Survival of Patients with Pediatric Ewing’s Sarcoma: A Population-Based Study
Ke-Na Dai,1 A-Bing Li2 1Department of Pediatrics; Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, 315040, People’s Republic of China; 2Department of Orthopedics, Ningbo Yinzhou Second Hospital, Ningbo, 315100, Zhejiang, People’s Republic of ChinaCorrespondence: A-Bing LiDepartment of Ortho...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2021-09-01
|
| Series: | International Journal of General Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/an-efficient-nomogram-to-predict-overall-survival-of-patients-with-ped-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1818650336249774080 |
|---|---|
| author | Dai KN Li AB |
| author_facet | Dai KN Li AB |
| author_sort | Dai KN |
| collection | DOAJ |
| description | Ke-Na Dai,1 A-Bing Li2 1Department of Pediatrics; Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, 315040, People’s Republic of China; 2Department of Orthopedics, Ningbo Yinzhou Second Hospital, Ningbo, 315100, Zhejiang, People’s Republic of ChinaCorrespondence: A-Bing LiDepartment of Orthopedics, Ningbo Yinzhou Second Hospital, Ningbo, Zhejiang, 315100, People’s Republic of ChinaTel +86-15088557621Email bing19890807@hotmail.comBackground: The objective of our study was to develop and validate a nomogram to predict the overall survival (OS) of patients with pediatric Ewing’s sarcoma (PES).Methods: Age, gender, race, tumor stage, tumor size, tumor site, treatment method, and survival time were collected from patients diagnosed with PES between 2004 and 2016 from the Surveillance, Epidemiology, and End Results (SEER) database. A total of 772 patients were randomly allocated to a training dataset (n = 579) and a validation dataset (n = 193). Then, univariate and multivariate analyses were performed to determine the prognostic effect of the selected variables. A nomogram was constructed to estimate the OS and it was further assessed using the concordance index (C-index), calibration curves, and receiver operating characteristic (ROC).Results: Age, race, tumor size, and tumor stage were included in the nomogram. The C-index was 0.77 in the OS for the training dataset. The C-index for the validation dataset of the OS prediction was 0.75. Calibration plots and ROC curves showed excellent predictive accuracy.Conclusion: Age, race, tumor stage, and tumor size were independent prognostic factors for patients with PES. The nomogram showed an accurate and reliable prognostic performance for PES patients.Keywords: nomogram, prognosis, SEER program, pediatric Ewing’s sarcoma |
| first_indexed | 2024-12-17T01:48:36Z |
| format | Article |
| id | doaj.art-b2eeebfafb3d46b5a11a5b1a8e7b0b70 |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-12-17T01:48:36Z |
| publishDate | 2021-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-b2eeebfafb3d46b5a11a5b1a8e7b0b702022-12-21T22:08:07ZengDove Medical PressInternational Journal of General Medicine1178-70742021-09-01Volume 146101610969217An Efficient Nomogram to Predict Overall Survival of Patients with Pediatric Ewing’s Sarcoma: A Population-Based StudyDai KNLi ABKe-Na Dai,1 A-Bing Li2 1Department of Pediatrics; Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, 315040, People’s Republic of China; 2Department of Orthopedics, Ningbo Yinzhou Second Hospital, Ningbo, 315100, Zhejiang, People’s Republic of ChinaCorrespondence: A-Bing LiDepartment of Orthopedics, Ningbo Yinzhou Second Hospital, Ningbo, Zhejiang, 315100, People’s Republic of ChinaTel +86-15088557621Email bing19890807@hotmail.comBackground: The objective of our study was to develop and validate a nomogram to predict the overall survival (OS) of patients with pediatric Ewing’s sarcoma (PES).Methods: Age, gender, race, tumor stage, tumor size, tumor site, treatment method, and survival time were collected from patients diagnosed with PES between 2004 and 2016 from the Surveillance, Epidemiology, and End Results (SEER) database. A total of 772 patients were randomly allocated to a training dataset (n = 579) and a validation dataset (n = 193). Then, univariate and multivariate analyses were performed to determine the prognostic effect of the selected variables. A nomogram was constructed to estimate the OS and it was further assessed using the concordance index (C-index), calibration curves, and receiver operating characteristic (ROC).Results: Age, race, tumor size, and tumor stage were included in the nomogram. The C-index was 0.77 in the OS for the training dataset. The C-index for the validation dataset of the OS prediction was 0.75. Calibration plots and ROC curves showed excellent predictive accuracy.Conclusion: Age, race, tumor stage, and tumor size were independent prognostic factors for patients with PES. The nomogram showed an accurate and reliable prognostic performance for PES patients.Keywords: nomogram, prognosis, SEER program, pediatric Ewing’s sarcomahttps://www.dovepress.com/an-efficient-nomogram-to-predict-overall-survival-of-patients-with-ped-peer-reviewed-fulltext-article-IJGMnomogramprognosisseer programpediatric ewing’s sarcoma |
| spellingShingle | Dai KN Li AB An Efficient Nomogram to Predict Overall Survival of Patients with Pediatric Ewing’s Sarcoma: A Population-Based Study International Journal of General Medicine nomogram prognosis seer program pediatric ewing’s sarcoma |
| title | An Efficient Nomogram to Predict Overall Survival of Patients with Pediatric Ewing’s Sarcoma: A Population-Based Study |
| title_full | An Efficient Nomogram to Predict Overall Survival of Patients with Pediatric Ewing’s Sarcoma: A Population-Based Study |
| title_fullStr | An Efficient Nomogram to Predict Overall Survival of Patients with Pediatric Ewing’s Sarcoma: A Population-Based Study |
| title_full_unstemmed | An Efficient Nomogram to Predict Overall Survival of Patients with Pediatric Ewing’s Sarcoma: A Population-Based Study |
| title_short | An Efficient Nomogram to Predict Overall Survival of Patients with Pediatric Ewing’s Sarcoma: A Population-Based Study |
| title_sort | efficient nomogram to predict overall survival of patients with pediatric ewing rsquo s sarcoma a population based study |
| topic | nomogram prognosis seer program pediatric ewing’s sarcoma |
| url | https://www.dovepress.com/an-efficient-nomogram-to-predict-overall-survival-of-patients-with-ped-peer-reviewed-fulltext-article-IJGM |
| work_keys_str_mv | AT daikn anefficientnomogramtopredictoverallsurvivalofpatientswithpediatricewingrsquossarcomaapopulationbasedstudy AT liab anefficientnomogramtopredictoverallsurvivalofpatientswithpediatricewingrsquossarcomaapopulationbasedstudy AT daikn efficientnomogramtopredictoverallsurvivalofpatientswithpediatricewingrsquossarcomaapopulationbasedstudy AT liab efficientnomogramtopredictoverallsurvivalofpatientswithpediatricewingrsquossarcomaapopulationbasedstudy |