Synthesis, characterization, antimicrobial, and pharmacological evaluation of some 2, 5-disubstituted sulfonyl amino 1,3,4-oxadiazole and 2-amino-disubstituted 1,3,4-thiadiazole derivatives
The presence of heterocyclic structures in diverse types of compounds, this is strongly indicative of the profound effect like structure exerts on physiologic activity, and recognition of this is abundantly reflected in efforts to find useful synthetic drugs. The search for better pharmacological ac...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Journal of Advanced Pharmaceutical Technology & Research |
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| Online Access: | http://www.japtr.org/article.asp?issn=2231-4040;year=2014;volume=5;issue=4;spage=196;epage=201;aulast=Pal |
| _version_ | 1818991869273571328 |
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| author | Dilipkumar Pal Rohit Tripathi Desh Deepak Pandey Preety Mishra |
| author_facet | Dilipkumar Pal Rohit Tripathi Desh Deepak Pandey Preety Mishra |
| author_sort | Dilipkumar Pal |
| collection | DOAJ |
| description | The presence of heterocyclic structures in diverse types of compounds, this is strongly indicative of the profound effect like structure exerts on physiologic activity, and recognition of this is abundantly reflected in efforts to find useful synthetic drugs. The search for better pharmacological active drug and the importance of disubstituted 1,3,4-oxadiazole and 1,3,4-thiadiazole as active pharmacophores, prompted us to design, synthesize, characterize, and evaluate a series of differently substituted sulfonyl amino 1,3,4-oxadiazole and 1,3,4-thiadiazole for their potential antimicrobial, analgesic and antiinflammatory activity, respectively. New sulfonyl amino 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives were synthesized by intramolecular cyclization of thiosemicarbazide in alkaline medium. Reactions were carried out by the reaction between aromatic carbonyl halide and thiosemicarbazide. |
| first_indexed | 2024-12-20T20:17:07Z |
| format | Article |
| id | doaj.art-b2f388c0f2fa4c9c9df448a8c5747d60 |
| institution | Directory Open Access Journal |
| issn | 2231-4040 0976-2094 |
| language | English |
| last_indexed | 2024-12-20T20:17:07Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Advanced Pharmaceutical Technology & Research |
| spelling | doaj.art-b2f388c0f2fa4c9c9df448a8c5747d602022-12-21T19:27:41ZengWolters Kluwer Medknow PublicationsJournal of Advanced Pharmaceutical Technology & Research2231-40400976-20942014-01-015419620110.4103/2231-4040.143040Synthesis, characterization, antimicrobial, and pharmacological evaluation of some 2, 5-disubstituted sulfonyl amino 1,3,4-oxadiazole and 2-amino-disubstituted 1,3,4-thiadiazole derivativesDilipkumar PalRohit TripathiDesh Deepak PandeyPreety MishraThe presence of heterocyclic structures in diverse types of compounds, this is strongly indicative of the profound effect like structure exerts on physiologic activity, and recognition of this is abundantly reflected in efforts to find useful synthetic drugs. The search for better pharmacological active drug and the importance of disubstituted 1,3,4-oxadiazole and 1,3,4-thiadiazole as active pharmacophores, prompted us to design, synthesize, characterize, and evaluate a series of differently substituted sulfonyl amino 1,3,4-oxadiazole and 1,3,4-thiadiazole for their potential antimicrobial, analgesic and antiinflammatory activity, respectively. New sulfonyl amino 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives were synthesized by intramolecular cyclization of thiosemicarbazide in alkaline medium. Reactions were carried out by the reaction between aromatic carbonyl halide and thiosemicarbazide.http://www.japtr.org/article.asp?issn=2231-4040;year=2014;volume=5;issue=4;spage=196;epage=201;aulast=Pal1334-oxadiazole4-thiadiazolesemicarbazidesulphonyl amino 1thiosemicarbazide |
| spellingShingle | Dilipkumar Pal Rohit Tripathi Desh Deepak Pandey Preety Mishra Synthesis, characterization, antimicrobial, and pharmacological evaluation of some 2, 5-disubstituted sulfonyl amino 1,3,4-oxadiazole and 2-amino-disubstituted 1,3,4-thiadiazole derivatives Journal of Advanced Pharmaceutical Technology & Research 1 3 3 4-oxadiazole 4-thiadiazole semicarbazide sulphonyl amino 1 thiosemicarbazide |
| title | Synthesis, characterization, antimicrobial, and pharmacological evaluation of some 2, 5-disubstituted sulfonyl amino 1,3,4-oxadiazole and 2-amino-disubstituted 1,3,4-thiadiazole derivatives |
| title_full | Synthesis, characterization, antimicrobial, and pharmacological evaluation of some 2, 5-disubstituted sulfonyl amino 1,3,4-oxadiazole and 2-amino-disubstituted 1,3,4-thiadiazole derivatives |
| title_fullStr | Synthesis, characterization, antimicrobial, and pharmacological evaluation of some 2, 5-disubstituted sulfonyl amino 1,3,4-oxadiazole and 2-amino-disubstituted 1,3,4-thiadiazole derivatives |
| title_full_unstemmed | Synthesis, characterization, antimicrobial, and pharmacological evaluation of some 2, 5-disubstituted sulfonyl amino 1,3,4-oxadiazole and 2-amino-disubstituted 1,3,4-thiadiazole derivatives |
| title_short | Synthesis, characterization, antimicrobial, and pharmacological evaluation of some 2, 5-disubstituted sulfonyl amino 1,3,4-oxadiazole and 2-amino-disubstituted 1,3,4-thiadiazole derivatives |
| title_sort | synthesis characterization antimicrobial and pharmacological evaluation of some 2 5 disubstituted sulfonyl amino 1 3 4 oxadiazole and 2 amino disubstituted 1 3 4 thiadiazole derivatives |
| topic | 1 3 3 4-oxadiazole 4-thiadiazole semicarbazide sulphonyl amino 1 thiosemicarbazide |
| url | http://www.japtr.org/article.asp?issn=2231-4040;year=2014;volume=5;issue=4;spage=196;epage=201;aulast=Pal |
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