Unusual clinical presentation of anaplastic large cell lymphoma
Anaplastic large cell lymphoma (ALCL), a well-recognized entity, presents a varied clinical picture and epidemiological characteristics associated with the expression of the anaplastic lymphoma kinase (ALK) protein. When classic symptoms are present (weight loss, fever, and night sweats) and combine...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of São Paulo
2014-03-01
|
| Series: | Autopsy and Case Reports |
| Subjects: | |
| Online Access: | http://www.revistas.usp.br/autopsy/article/view/81207 |
| _version_ | 1818150472369831936 |
|---|---|
| author | Fernando Peixoto Ferraz de Campos Maria Claudia Nogueira Zerbini Aloisio Felipe-Silva Angélica Braz Simões Silvana Maria Lovisolo Leonardo Gomes da Fonseca Lorena Laborda |
| author_facet | Fernando Peixoto Ferraz de Campos Maria Claudia Nogueira Zerbini Aloisio Felipe-Silva Angélica Braz Simões Silvana Maria Lovisolo Leonardo Gomes da Fonseca Lorena Laborda |
| author_sort | Fernando Peixoto Ferraz de Campos |
| collection | DOAJ |
| description | Anaplastic large cell lymphoma (ALCL), a well-recognized entity, presents a varied clinical picture and epidemiological characteristics associated with the expression of the anaplastic lymphoma kinase (ALK) protein. When classic symptoms are present (weight loss, fever, and night sweats) and combine with enlarged and easily accessible peripheral lymph nodes, diagnosis is not that difficult. But when the clinical presentation is nonspecific, a tough diagnostic task is required. HIV infection is highly associated with neoplastic disorders—mainly with those of hematological origin. However, ALCL is exceptionally associated with HIV infection, and the few reported cases are ALK– ALCL. The authors report two cases of ALK+ ALCL with the unusual clinical presentation: one is associated with the HIV infection and the other presents as a fever of unknown origin (FUO) without peripheral lymphadenopathy. The latter was autopsied and was characterized by nodal and extra nodal involvement. The authors call attention to the plurality of clinical presentation of this group of lymphomas, and the early indication of bone marrow examination in cases of an FUO with elevated hepatic enzymes and lactic dehydrogenase. |
| first_indexed | 2024-12-11T13:23:28Z |
| format | Article |
| id | doaj.art-b2f3db7d0a254436841ab3e3694d0701 |
| institution | Directory Open Access Journal |
| issn | 2236-1960 |
| language | English |
| last_indexed | 2024-12-11T13:23:28Z |
| publishDate | 2014-03-01 |
| publisher | University of São Paulo |
| record_format | Article |
| series | Autopsy and Case Reports |
| spelling | doaj.art-b2f3db7d0a254436841ab3e3694d07012022-12-22T01:05:41ZengUniversity of São PauloAutopsy and Case Reports2236-19602014-03-014110.4322/acr.%y.8120777830Unusual clinical presentation of anaplastic large cell lymphomaFernando Peixoto Ferraz de Campos0Maria Claudia Nogueira Zerbini1Aloisio Felipe-Silva2Angélica Braz Simões3Silvana Maria Lovisolo4Leonardo Gomes da Fonseca5Lorena Laborda6Divisão de Clínica Médica do Hospital Universitário da USPDepartamento de Patologia da Faculdade de Medicina da USPServiço de Anatomia Patológica do Hospital Universitário da USPServiço de Anatomia Patológica do Hospital Universitário da USPServiço de Anatomia Patológica do Hospital Universitário da USPInstituto do Câncer de São PauloDivisão de Clínica Médica do Hospital Universitário da USPAnaplastic large cell lymphoma (ALCL), a well-recognized entity, presents a varied clinical picture and epidemiological characteristics associated with the expression of the anaplastic lymphoma kinase (ALK) protein. When classic symptoms are present (weight loss, fever, and night sweats) and combine with enlarged and easily accessible peripheral lymph nodes, diagnosis is not that difficult. But when the clinical presentation is nonspecific, a tough diagnostic task is required. HIV infection is highly associated with neoplastic disorders—mainly with those of hematological origin. However, ALCL is exceptionally associated with HIV infection, and the few reported cases are ALK– ALCL. The authors report two cases of ALK+ ALCL with the unusual clinical presentation: one is associated with the HIV infection and the other presents as a fever of unknown origin (FUO) without peripheral lymphadenopathy. The latter was autopsied and was characterized by nodal and extra nodal involvement. The authors call attention to the plurality of clinical presentation of this group of lymphomas, and the early indication of bone marrow examination in cases of an FUO with elevated hepatic enzymes and lactic dehydrogenase.http://www.revistas.usp.br/autopsy/article/view/81207LymphomaLarge-CellAnaplasticAcquired Immunodeficiency SyndromeFever of Unknown OriginAutopsy. |
| spellingShingle | Fernando Peixoto Ferraz de Campos Maria Claudia Nogueira Zerbini Aloisio Felipe-Silva Angélica Braz Simões Silvana Maria Lovisolo Leonardo Gomes da Fonseca Lorena Laborda Unusual clinical presentation of anaplastic large cell lymphoma Autopsy and Case Reports Lymphoma Large-Cell Anaplastic Acquired Immunodeficiency Syndrome Fever of Unknown Origin Autopsy. |
| title | Unusual clinical presentation of anaplastic large cell lymphoma |
| title_full | Unusual clinical presentation of anaplastic large cell lymphoma |
| title_fullStr | Unusual clinical presentation of anaplastic large cell lymphoma |
| title_full_unstemmed | Unusual clinical presentation of anaplastic large cell lymphoma |
| title_short | Unusual clinical presentation of anaplastic large cell lymphoma |
| title_sort | unusual clinical presentation of anaplastic large cell lymphoma |
| topic | Lymphoma Large-Cell Anaplastic Acquired Immunodeficiency Syndrome Fever of Unknown Origin Autopsy. |
| url | http://www.revistas.usp.br/autopsy/article/view/81207 |
| work_keys_str_mv | AT fernandopeixotoferrazdecampos unusualclinicalpresentationofanaplasticlargecelllymphoma AT mariaclaudianogueirazerbini unusualclinicalpresentationofanaplasticlargecelllymphoma AT aloisiofelipesilva unusualclinicalpresentationofanaplasticlargecelllymphoma AT angelicabrazsimoes unusualclinicalpresentationofanaplasticlargecelllymphoma AT silvanamarialovisolo unusualclinicalpresentationofanaplasticlargecelllymphoma AT leonardogomesdafonseca unusualclinicalpresentationofanaplasticlargecelllymphoma AT lorenalaborda unusualclinicalpresentationofanaplasticlargecelllymphoma |