Impact of Immunosenescence on Viral Infections with an Emphasis on COVID-19
During aging, the immune system (IS) undergoes remarkable changes known as immunosenescence, a multifactorial and dynamic phenomenon that affects both natural and acquired immunity and plays an important role in most chronic diseases in older people. Among the determinants of immunosenescence, we fi...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2023-09-01
|
| Series: | Frontiers in Bioscience-Landmark |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBL/28/9/10.31083/j.fbl2809225 |
| _version_ | 1797665023243321344 |
|---|---|
| author | Giuseppe Murdaca Francesca Paladin Gabriella Martino Sebastiano Gangemi |
| author_facet | Giuseppe Murdaca Francesca Paladin Gabriella Martino Sebastiano Gangemi |
| author_sort | Giuseppe Murdaca |
| collection | DOAJ |
| description | During aging, the immune system (IS) undergoes remarkable changes known as immunosenescence, a multifactorial and dynamic phenomenon that affects both natural and acquired immunity and plays an important role in most chronic diseases in older people. Among the determinants of immunosenescence, we find a low-grade sterile chronic inflammation, known as “inflamm-aging”. This condition of chronic inflammation causes a progressive reduction in the ability to trigger antibody and cellular responses effective against infections and vaccinations. In this review, we wanted to explore the role of immunosenescence and inflamm-aging as determinants of the immunological aging process and predisposing viral infections phenomena, with a particular reference to cytomegalovirus (CMV), varicella zoster virus (VZV), influenza virus (IFV) diseases and SARS-CoV2. IS aging is also reflected in a reduction in the antibody response to vaccinations, hence there is a need to expand trials to elderly patients, in order to identify the most appropriate methods for developing effective and safe vaccination and preventive strategies. |
| first_indexed | 2024-03-11T19:37:52Z |
| format | Article |
| id | doaj.art-b2f644c5ecb043539f115a8bd460223b |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-03-11T19:37:52Z |
| publishDate | 2023-09-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-b2f644c5ecb043539f115a8bd460223b2023-10-06T13:06:36ZengIMR PressFrontiers in Bioscience-Landmark2768-67012023-09-0128922510.31083/j.fbl2809225S2768-6701(23)01037-7Impact of Immunosenescence on Viral Infections with an Emphasis on COVID-19Giuseppe Murdaca0Francesca Paladin1Gabriella Martino2Sebastiano Gangemi3Department of Internal Medicine, University of Genoa, 16132 Genoa, ItalyDepartment of Internal Medicine, University of Genoa, 16132 Genoa, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, ItalyAllergy and Clinical Immunology Unit, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, ItalyDuring aging, the immune system (IS) undergoes remarkable changes known as immunosenescence, a multifactorial and dynamic phenomenon that affects both natural and acquired immunity and plays an important role in most chronic diseases in older people. Among the determinants of immunosenescence, we find a low-grade sterile chronic inflammation, known as “inflamm-aging”. This condition of chronic inflammation causes a progressive reduction in the ability to trigger antibody and cellular responses effective against infections and vaccinations. In this review, we wanted to explore the role of immunosenescence and inflamm-aging as determinants of the immunological aging process and predisposing viral infections phenomena, with a particular reference to cytomegalovirus (CMV), varicella zoster virus (VZV), influenza virus (IFV) diseases and SARS-CoV2. IS aging is also reflected in a reduction in the antibody response to vaccinations, hence there is a need to expand trials to elderly patients, in order to identify the most appropriate methods for developing effective and safe vaccination and preventive strategies.https://www.imrpress.com/journal/FBL/28/9/10.31083/j.fbl2809225immunosenescenceinflamm-agingcmvvzvifvcovid-19vaccine immunogenicity |
| spellingShingle | Giuseppe Murdaca Francesca Paladin Gabriella Martino Sebastiano Gangemi Impact of Immunosenescence on Viral Infections with an Emphasis on COVID-19 Frontiers in Bioscience-Landmark immunosenescence inflamm-aging cmv vzv ifv covid-19 vaccine immunogenicity |
| title | Impact of Immunosenescence on Viral Infections with an Emphasis on COVID-19 |
| title_full | Impact of Immunosenescence on Viral Infections with an Emphasis on COVID-19 |
| title_fullStr | Impact of Immunosenescence on Viral Infections with an Emphasis on COVID-19 |
| title_full_unstemmed | Impact of Immunosenescence on Viral Infections with an Emphasis on COVID-19 |
| title_short | Impact of Immunosenescence on Viral Infections with an Emphasis on COVID-19 |
| title_sort | impact of immunosenescence on viral infections with an emphasis on covid 19 |
| topic | immunosenescence inflamm-aging cmv vzv ifv covid-19 vaccine immunogenicity |
| url | https://www.imrpress.com/journal/FBL/28/9/10.31083/j.fbl2809225 |
| work_keys_str_mv | AT giuseppemurdaca impactofimmunosenescenceonviralinfectionswithanemphasisoncovid19 AT francescapaladin impactofimmunosenescenceonviralinfectionswithanemphasisoncovid19 AT gabriellamartino impactofimmunosenescenceonviralinfectionswithanemphasisoncovid19 AT sebastianogangemi impactofimmunosenescenceonviralinfectionswithanemphasisoncovid19 |